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proliferation of mesangial cell
    Experimental study on effect of prescription "Nephritis Ⅲ" on proliferation of mesangial cell and PAF production
    肾炎3号对系膜细胞增殖及产生PAF的影响
    Results: Curcumin at the concentration equal or over 6. 25 μmol/L was able to inhibit the proliferation of mesangial cell in a dose-dependent manner.
    结果:当姜黄素浓度≥6.25μmol/L时,系膜细胞增殖明显受到抑制,且表现为浓度依赖性;
    RUSULTS ① Effect of different concentrations glucose on the proliferation of mesangial cell Compared with low concentrations glucose 10 mmol/L 20 mmol/L glucose could accelerate the proliferation of mesangial cell during 96 hours experiment period but only had a statistically significant difference at 72 and 96 hours P < 0.05.
    结果:①不同浓度的葡萄糖对系膜细胞增殖的影响:与低糖组(10mmol/L)比较,20mmol/L葡萄糖在实验的96h里能促进系膜细胞增殖,但仅在72h和96h具有统计学意义(P<0.05)。
    30 mmol/L glucose could significantly accelerate the proliferation of mesangial cell than that of 10 mmol/L glucose from 24 hours to 96 hours P < 0.05 or P < 0.01 and this effect was increasing with time in 72 hours and reduced after 72 hours.
    30mmol/L葡萄糖在实验的24h至96h里均能显著促进系膜细胞增殖(P<0.05或P<0.01),72h内随着作用时间的延长,促进增殖作用越明显,72h后作用减弱,但仍有统计学意义;
    40 mmol/L glucose could significantly increase the proliferation of mesangial cell than of low concentrations glucose in 48 hours P < 0.05 and this effect was reduced after 48 hours and even conversed to restrain effect.
    40mmol/L浓度的葡萄糖在48h内对系膜细胞增殖有促进作用(P<0.05),48h后作用减弱,甚至转为抑制。
    The expression of COX-2 mRNA and protein were upregulated by LDL of the concentration from 3.125 to 100.000 μg/mL,when the LDL concentration was from 0.000 to 50.000 μg/mL,the expression of COX-2 mRNA and protein was correlated with LDL concentration and the proliferation of mesangial cell.
    以浓度为3.125~100.000μg/mL的LDL刺激系膜细胞,可上调COX-2mRNA和蛋白的表达,在LDL0.000~50.000μg/mL的范围内,COX-2mRNA和蛋白的表达与LDL浓度、系膜细胞增殖呈正相关。
    [Conclusions] The proliferation of mesangial cells and the expression of COX-2 are induced by LDL,when the LDL concentration is from 0.000 to 50.000 μg/mL,the proliferation of mesangial cell is correlated with LDL concentration,and the expression of COX-2 is correlated with LDL concentration and the proliferation of mesangial cell.
    结论LDL可以诱导系膜细胞增殖,上调COX-2表达,在LDL0.000~50.000μg/mL的范围内,系膜细胞增殖与LDL浓度具有相关性,COX-2的表达与LDL浓度、系膜细胞增殖具有相关性。
    The results revealed that the increase of the expression of ICAM-1 in glomeruli closely connected with the degree of proliferation of mesangial cell. The more severe the mesangial cell proliferation was, the higher level the expression of the ICAM-1 was.
    结果显示:在系膜细胞增殖的肾小球内细胞间粘附分子-1含量增加,并随病变进展明显增加,且与系膜细胞增殖程度显著正相关。
    The effect of LMWH on patients with proliferative glomerulonephritis may be associated with inhibiting the proliferation of mesangial cell and the accumulation of mesangial matrix.
    提示 ,临床上LMWH能通过对增生性肾炎患者系膜细胞增殖和系膜基质积聚的抑制作用而发挥效应。
    Conclusion No. 1 Tongshenluo can suppress the proliferation of mesangial cell by inhabiting DNA synthesis and accelerating apoptosis.
    结论通肾络1号抑制高糖诱导的系膜细胞增殖,很可能是通过抑制细胞分裂、复制,促进细胞凋亡实现的。
 

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