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mesangial cells
    NF-κB Involved in the Transcription Regulation of TGF-β1 Induced by Ox-LDL in Rat Glomerular Mesangial Cells
    NF-κB调控氧化LDL激活系膜细胞TGF-β1转录的研究
    The Inhibitive Effects and Mechanisms of PPARγ1 on the Extracellular Matrix of Mesangial Cells
    PPARγ1对系膜细胞外基质生成的抑制作用及其机制
    Effect of Emodin on c- myc proto- oncogene expression in mesangial cells
    大黄素对系膜细胞c-myc原癌基因表达的影响
    Effect of IL-6 on c-myc protooncogene expression in human mesangial cells and the down-regulation by Emodin
    IL-6对人系膜细胞c-myc原癌基因表达的影响以及大黄素的拮抗作用
    Role of transforming growth factor-βin the growth inhibition by cultured rat mesangial cells in
    转化生长因子β在高糖培养条件下系膜细胞生长抑制中的作用
    DUAL MODULATORY EFFECTS OF U 46619 ON DNA SYNTHESIS OF MESANGIAL CELLS
    U46619双向调节系膜细胞DNA合成的研究
    Effect of rIL - 1 on bioactivity and gene expression of IL - 6 in mesangial cells
    重组白细胞介素1对系膜细胞产生与表达白细胞介素6的影响
    Results:There is very low expression of CDK2 in quiescent mesangial cells of normal rats, but increased expression in mesangial cells of rats with Thy1 glomerulonephritis, accompanying with the proliferation of mesangial cells.
    结果:在正常大鼠系膜细胞CDK2存在低表达,而在肾炎大鼠随系膜细胞增生,其CDK2表达增加。
    Conclusion:The proliferation of mesangial cells is related with the high expression of CDK2. Valsartan can inhibit this process and relieve the mesangial matrix expansion by means of reducing expression of CDK2, suggesting that valsartan has a certain therapeutic effect on Thy1 glomerulonephritis rats.
    结论:肾小球系膜细胞的增生与其CDK2的高表达相关,缬沙坦可抑制系膜细胞CDK2的高表达,抑制系膜细胞增殖及系膜扩张。 提示缬沙坦对Thy1肾炎大鼠有一定治疗作用。
    Purpose To investigate the effects of all-trans retinoic acid (atRA) on transforming growth factor-β1 (TGF-β1)-induced fibronectin expression and Smad pathway activation in cultured rat renal mesangial cells.
    目的采用转化生长因子-β1(transforming growth factor-β1,TGF-β1)在体外刺激大鼠肾系膜细胞表达纤维连接蛋白(fibronectin),观察全反式维甲酸(all-trans retinoicacid,atRA)对它的作用及对TGF-β1的Smad通路的影响。
    Methods Fibronectin expression, phosphorylation of Smad 2, nuclear translocation of phospho-Smad 2, total Smad 2/3, Smad 4 induced by TGF-β1 in the presence or absence of atRA in the mesangial cells were analysed by Western blotting.
    方法用Western blot方法检测TGF-β1诱导的肾系膜细胞纤维连接蛋白表达,Smad2的磷酸化,磷酸化Smad2、总Smad2/3和Smad4的核转位,以及atRA对TGF-β1的这些作用的影响。 结果atRA能抑制TGF-β1诱导的肾系膜细胞纤维连接蛋白表达。
    Methods The rat glomerular mesangial cells were infected with retroviral supernatants of pLXSN-A-MCP-1 containing antisense MCP-1 and verified by Sorthem blot analysis and PCR.
    方法用逆转录病毒感染体外培养的系膜细胞,得到转染反义MCP-1的系膜细胞,经PCR及Southern印迹鉴定外源基因在系膜细胞基因组DNA上的整合。 脂多糖(LPS)刺激反义MCP-1系膜细胞,以正常系膜细胞及转染空白载体的系膜细胞为对照,观察其增生情况。
    Antisense MCP-1 decreases the proliferation of mesangial cells in inflammation.
    (3)反义MCP-1的转染可降低系膜细胞在炎症状态时的增生。
    CCR2 also expresses in mesangial cells. MCP-1 is a autocrine chemokine.
    (4)大鼠系膜细胞具有CCR2的表达,在炎症状态时形成MCP-1、CCR2的自分泌环路。
    CONCLUSION: Pravastatin could inbibit high glucose-induced proliferation of mesangial cells, and attenuated oxidative stress.
    结论:普伐他汀能抑制高糖环境下的系膜细胞增殖,并显著减少高糖诱导的氧化应激水平。
    TX Expression of αSMA correlated with phenotype change of mesangial cells in human glomerulonephritis
    肾小球肾炎中系膜细胞α-平滑肌肌动蛋白表达与细胞表型变化的关系
    EFFECT OF INTERLEUKIN1 ON SUBFAMILY OF MITOGENACTIVATED PROTEIN KINASES IN RENAL MESANGIAL CELLS
    白细胞介素1对肾系膜细胞分裂原活化蛋白激酶不同亚类的作用
    EFFECTS OF INTERLEUKIN 1 AND INTERLEUKIN 1 RECEPTOR ANTAGONIST ON PROLIFERATION AND NITRIC OXIDE SYNTHESIS OF MESANGIAL CELLS
    白细胞介素-1β及其受体拮抗剂对系膜细胞增殖及产生一氧化氮的影响
    Effect of thrombin on cell proliferation and plasminogen activator inhibitor type(PAI-1) expression in human embryonic glomerular mesangial cells
    凝血酶诱导人胚胎肾系膜细胞增殖和PAI-1表达的研究
    Effects of Yishenhuoxuexiezhuo Decoction on Expression of TGF β_1 in Rat Mesangial Cells
    益肾活血泄浊汤对大鼠系膜细胞转化生长因子β_1表达的影响
 

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