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gastric cardia adenocarcinoma
    Analysis of tumor suppressor gene P53 mutation in gastric cardia adenocarcinoma
    贲门腺癌组织肿瘤抑制基因P53突变分析
    Correlation between the Expression of ER,PR,PCNA and the Grades of Gastric Cardia Adenocarcinoma
    贲门腺癌雌孕激素受体及PCNA表达相关性初探
    Gastric cardia adenocarcinoma (GCA) is one of the most common malignant digestive diseases in northern China.
    贲门腺癌(Gastric cardia adenocarcinoma,GCA)是我国北方地区最常见的恶性肿瘤之一。
    BackgroundEsophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) remain commonest malignancies in northern China, especially in Linzhou city (formerly Linxian) and the nearby countries, such as Huixian and Anyang in Henan province.
    食管鳞状细胞癌(Esophageal squamous cell carcinoma,SCC)和贲门腺癌(Gastric cardia adenocarcinoma,GCA)是我国北方地区,尤其是河南省林州市(原林县)及其毗邻的安阳、辉县等地区最常见的恶性肿瘤。
    Results:Among the 37 cases of gastric cardia adenocarcinoma,18 cases showed consistant P53 positive immunoreactivity in the primary and lymph node metastatic cancer lesions(67%,12/28).
    结果:在37例贲门腺癌中,18例原发病灶和转移病灶配对组织中一致性P53免疫阳性反应的发生率为67%(12/18);
    The metastasis rate in gastric cardia adenocarcinoma with P53 positive immunostaining was higher (78%) than that in negative P53 immunostaining (29%)(P<0.05).
    P53免疫阳性的贲门腺癌淋巴结转移率(78%)明显高于P53免疫阴性的贲门腺癌淋巴结转移率(29%,P<0.05)。
    Methods: With mass survey, endoscopic biopsy, histopathology and immunohistochemistry methods, the study of expression of C erbB2 and c myc and their correlation with lesions' progression was performed on 84 symptom free subjects and 30 patients with esophageal squamous cell carcinoma (SCC) and 30 cases with gastric cardia adenocarcinoma (GCA).
    方法 :采用纤维内镜活检、组织病理学和免疫组织化学方法 ,对 84例无症状人群食管和贲门粘膜活检组织以及 30例食管鳞癌患者和 30例贲门腺癌患者的癌组织进行C erbB2和c myc的表达变化以及病理学的研究。
    Results: Of the 14 cases with concurrent cancers,p53 positive immunostaining rates in esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) were 72% (10/14) and 36% (5/14),respectively. The difference,however,was not significant ( χ 2=2.285,P >0.05).
    结果 :在 14例双源癌患者中 ,食管鳞癌和贲门腺癌p5 3阳性率分别为 72 % (10 / 14 )和 3 6% (5 / 14 ) ,统计学分析二者间阳性率无显著性差异 (χ2 =2 2 85 ,P >0 0 5 )。
    In gastric cardia: the prevalence of chronic superficial carditis (CSG), DYS, and intestinal metaplasia (IM) in the migrated subjects were higher than that in Linzhou subjects (P<0.05), however, the prevalence of chronic atrophic carditis (CAG) and gastric cardia adenocarcinoma (GCA) was similar between the migrated subjects and Linzhou subjects (P>0.05).
    ②贲门:移民村慢性浅表性贲门炎(CSG)、不典型增生(DYS)和肠上皮化生(IM)的检出率均高于林州居民(P<0.05),但两地区慢性萎缩性贲门炎(CAG)和贲门腺癌(GCA)的检出率相似(P>0.05);
    Methods: mdm2, cyclind1 and p16 protein were detected by immunohistochemical method (ABC) in 30 patients with concurrent carcinomas of esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA).
    方法:采用免疫组化ABC法,对河南食管癌高发区30例双源癌患者食管鳞癌(SCC)和贲门腺癌(GCA)组织中mdm2、CyclinD1和p16蛋白的表达进行检测。
    METHODS: mdm2, Bcl-2, bax and p53 protein expressions were detected by the immunohistochemical method (ABC) in 15 patients with concurrent cancers of the esophagus and gastric cardia (CC) in the same patient (occurring together with esophageal squamous cell carcinoma, and gastric cardia adenocarcinoma).
    方法:采用免疫组化卵白素-生物素-过氧化物酶复合物(ABC)法和组织病理学方法,分析15例双源癌患者(同时发生食管鳞癌和贲门腺癌)mdm2、Bcl-2、bax和p53蛋白的表达状况。
    Objective: To characterize the histochemistry and expression of P53,PCNA proteins on gastric cardia adenocarcinoma (GCA) .
    目的探讨贲门腺癌(Gastriccardia adenocarcinoma,GCA)的组织化学染色分类与P53和PCNA分子学特征。
    Results Pathological examination showed that, of the 31 samples, 24 were esophageal squamous cell carcinoma (SCC) and 7 were gastric cardia adenocarcinoma (AC).
    结果:31例手术标本中,病理检查发现24例食管鳞状细胞癌,7例为贲门腺癌
    Aim: To characterize the changes of PTEN expression in esophageal squamous cell carcinomas (SCC) and gastric cardia adenocarcinoma (GCA) and to correlate the changes with differentiation and lymph node metastasis.
    目的 :探讨PTEN蛋白在食管鳞癌和贲门腺癌组织中表达变化及其与细胞分化程度及淋巴结转移的关系。
    Method: MUC1 and C erbB2 protein expression in 25 patients with concurrent cancers from esophagus and gastric cardia (CC) in the same patient (occurring together with esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA)) was detected by immunohistochemical method (ABC).
    方法 :采用免疫组化卵白素 生物素 过氧化物酶复合物 (ABC)法和组织病理学方法 ,分析河南食管癌高发区 2 5例双源癌患者 (同时发生食管鳞癌和贲门腺癌 )MUC1和C erbB2蛋白的表达状况。
    Methods: p53 protein accumulation in 14 patients with concurrent carcinoma of the esophagus and gastric cardia (occurring together with esophageal squamous cell carcinoma and gastric cardia adenocarcinoma) was detected by immunohistochemical method (ABC).
    方法 :采用免疫组化卵白素 生物素 过氧化物酶复合物 (ABC)法和组织病理学方法 ,分析河南食管癌高发区林州市 14例双源癌患者 (同时发生食管鳞癌和贲门腺癌 )p5 3蛋白的表达状况。
    Results:①In esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA), the frequencies of the p53 positive immunostaining were 70% and 68%, respectively; ②The frequencies of p53 gene mutation were 58% and 53% in SCC and GCA, respectively;
    结果 :①食管鳞癌和贲门腺癌组织中p5 3蛋白过度表达的阳性率分别为 70 %和 6 8% ,p5 3基因突变率分别为 5 8%和 5 3% ,p5 3基因突变和蛋白过度表达的一致率分别为 6 4 %和 4 2 % ;
    Aim: To determine RASSF1A methylation in gastric cardia adenocarcinoma (GCA) tissue.
    目的:检测贲门腺癌组织中RASSF1A基因启动子的甲基化。
    Methods: P21~(WAF1) protein expression was detected by immunohistochemical method(ABC) in 15 patients with concurrent cancers of the esophagus and gastric cardia in the same patient occurring together with esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA).
    方法:采用组织病理学和免疫组化卵白素-生物素-过氧化物酶复合物(ABC)法,分析15例双源癌患者(同时发生食管鳞癌和贲门腺癌)P21WAF1蛋白的表达状况。
 

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