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cardiac adenocarcinoma
    A STUDY ON THE RELATIONSHIP OF PATHOMORPHOLOGY AND PROGNOSIS OF CARDIAC ADENOCARCINOMA
    贲门腺癌病理形态学与预后关系的研究
    Objective:To investigate whether the single nucleotide polymorphism (SNP) of DNA repair gene XPD at exon 10 Asp312Asn and exon 23 Lys751Gln correlated with the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in population at Ci County and She County, two high incidence regions of Hebei Province.
    目的探讨DNA修复基因XPD第10外显子Asp312Asn及第23外显子Lys751Gln单核苷酸多态性(SNP)与河北省食管癌、贲门癌高发区磁县和涉县人群食管鳞状细胞癌(ESCC)、贲门腺癌(GCA)发病风险的关系。
    Objective To investigate the correlation of XPC intron 9 PAT+/- and exon 15 A2920C SNPs with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region of Hebei Province.
    目的探讨DNA修复基因XPC第9内含子PAT+/-和第15外显子A2920C单核苷酸多态性(SNP)与河北省食管癌、贲门癌高发区磁县和涉县人群食管鳞状细胞癌(ESCC)和贲门腺癌(GCA)遗传易感性的关系。
    Objective To investigate the association of +54C/T single nucleotide polymorphisms in 3' untraslated region (UTR)of the CDH1 gene with susceptibilities and lymphatic metastases of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.
    目的:探讨CDH1基因3’非编码区(untranslated region,UTR)+54 C/T单核苷酸多态性与中国北方人食管鳞状细胞癌、贲门腺癌易感性和淋巴结转移的关系。
    Methods The CDH1+54C/T SNP was genotyped by polymerase-chain reaction-restriction fragment length polymorphism (PCR-RFLP ) analysis in 333 esophageal squamous cell carcinoma patients, 239 gastric cardiac adenocarcinoma patients and 343 healthy controls.
    方法:采用聚合酶链反应限制性片段长度多态性分析方法检测了333例食管鳞状细胞癌患者、239例贲门腺癌患者和343名健康对照的CDH1+54C/T单核苷多态性的基因型。
    Results A significant difference was observed in the CDH1 allelotype distribution among esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma patients and healthy controls (χ2=3.98 and 23.73, P=0.046 and 0.000, respectively).
    结果: CDH1 3’UTR+54C等位基因在食管鳞状细胞癌、贲门腺癌患者组和健康对照组中的分布有统计学差异(P=0.046和0.000)。
    Individuals with the +54C allele (C/T+C/C genotype) had significantly higher risk to develop esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma compared with the T/ T genotype.
    与T/T基因型相比,携带C等位基因(C/T+C/C基因型)可显著增加食管鳞状细胞癌和贲门腺癌的发病风险。
    Conclusion The CDH1 3'UTR + 54C/T SNP may modify the susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in Northern China.
    结论:CDH1 3’UTR+54C/T多态性可能与食管鳞状细胞癌和贲门腺癌的易感性相关。
    Objective:To investigate the possible association of the C→G single nucleotide polymor-phism(SNP) at the 540 position and C→T SNP at the 580 position in the 3'untranslated region of p16 ex-on3 with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region, Shexian county of North China.
    目的探讨p16(CDKN2/MTS-1/INK4α)基因第3外显子3'非编码区C540G和C580T两个单核苷酸多态性(SNP)与高发区涉县人群食管鳞状细胞癌(ESCC)和贲门腺癌(GCA)易感性的关系。
    PEPTIDERGIC INNERVATION IN CARDIAC ADENOCARCINOMA
    贲门腺癌组织中的肽能神经支配研究
    Clinical Analysis on the Surgical Treatment for Cardiac Adenocarcinoma
    贲门腺癌外科治疗的临床分析
    The influence of intraoperative combined therapy on prognosis of the patients with Cardiac adenocarcinoma
    贲门腺癌术中综合治疗对预后的影响
    Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma
    丝氨酸羟甲基转移酶基因C1420T多态性与食管鳞癌、贲门腺癌易感性的关系
    The expression and clinical significance of P170 protein in cardiac adenocarcinoma
    P170在贲门腺癌组织中的表达及临床意义的探讨
    Correlation between single nucleotide polymorphism of DNA repair gene XPD and the risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma
    XPD基因单核苷酸多态性与食管鳞状细胞癌、贲门腺癌发病风险的关联研究
    Correlation of XPC Polymorphisms to the Risk of Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma
    XPC基因多态性与食管鳞状细胞癌、贲门腺癌的发病风险
    This study was designed to investigate the correlation of three single nucleotide polymorphisms (SNPs), -160C/A and -347G/GA in the promoter region and +54C/T in 3'untraslated region(UTR), to susceptibilities and lymphatic metastases of esophageal squamous cell carcinoma(ESCC) and gastric cardiac adenocarcinoma (GCA) in North China population .
    本研究旨在探讨该基因启动子区-160C/A和-347G/GA以及3'非编码区(untranslated region,UTR)+54C/T单核苷酸多态性(single nucleotide polymorphism,SNP)与中国北方人食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)、贲门腺癌(gastric cardiac adenocarcinoma, GCA)易感性和淋巴结转移的关系。
    This study was designed to investigate the correlation of CDH1 C-160A and G-347GA single nucleotide polymorphisms(SNPs) to susceptibilities and lymphatic metastases of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in northern China population.
    本研究旨在探讨该基因启动子区C-160A和G-347GA单核苷多态性(single nucleotide polym orphism,SNP)与中国北方人食管鳞状细胞癌(esophagealsquam ous cellcarcinom a,ESCC)、贲门腺癌(gastric cardiacadenocarcinom a,GCA)易感性和淋巴结转移的关系。
    There’re 654 cases of cardiac carcinoma totally,with 561 cases of cardiac adenocarcinoma, 20 cases of cardiac squamous carcinoma,the rest 73 of other pathological typed cardiac carcinoma.
    贲门部癌肿654例,其中贲门腺癌561例,贲门鳞癌20例,其它病理类型贲门部癌肿73例。
    Result: The 1-year,3-year,5-year,10-year survival rate of cardiac adenocarcinoma is 50.9%,29.1%,15.9%,11.7% respectively.
    结果:贲门腺癌术后1年、3年、5年、10年生存率为50.9%、29.1%,15.9%,11.7%。
 

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