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negative symptoms
    Objective:To study the relationship between cerebrospinal(CSF)levels of serotonin(5-HT),5-hydroxyindoleacetic acid(5HIAA),norepinephrine(NE),3-methoxy-4-hydrophenylethylene(MHPG)and clinical manifestations of schizophrenia. Method:CSF levels of the above neurotransmitters and metabolites were determined with high pressure liquid chromatography in 42 schizophrenic patients with positive,25 with negative symptoms and 10 normal control.
    应用高压液相色谱(HPLC)对42例阳性精神分裂症、25例阴性精神分裂症和10例健康正常对照组脑脊液中(CSF)5—羟色胺(5—HT)、5—羟吲哚乙酸(5—HIAA)、去甲肾上腺素(NE)、3—甲基—4—羟基苯乙二醇(MHPG)进行测试。
    Results:CSF level of NE,MHPG,ratio of 5HIAA/MHPG of schizophrenic patients with positive symptoms were significantly lower than that of normal control. The 5HT/NE ratio was significantly higher in patients with positive than negative symptoms.
    并以5—HT/NE、5—HIAA/MHPG为其相互作用指标,结果发现,阳性精神分裂症NE、MHPG、5—HIAA/MHPG显著低于正常对照组,而且NE、5—HIAA显著低于阴性精神分裂症,但是5—HT/NE则显著高于阴性精神分裂症
    Results:The baseline plasma cortisol level at 8:00 am before DST was significantly higher in subjects with positive than negative symptoms.
    结果: 阳性精神分裂症 D S T 前晨8 时基础血浆皮质醇水平显著高于阴性精神分裂症
    The post DST plasma cortisol level at 4:00 pm and 11:00 pm were both significantly lower in subjects with positive than negative symptoms.
    阳性精神分裂症 D S T 后下午4 时和11 时两个时点血浆皮质醇水平均低于阴性精神分裂症
    Objective To access the efficacy of antipsychotics in type Ⅰ and type Ⅱ schizophrenia Methods All subjects were classified in to type Ⅰ or type Ⅱ schizophrenia according to Andersen's diagnostic criteria for positive and negative symptoms and randomized to receive chlorpromazine,clozapine,or sulpiride for 6 weeks.
    目的前瞻性研究抗精神病药对Ⅰ型、Ⅱ型精神分裂症的疗效。 方法运用Andreasen等的阳性、阴性精神分裂症诊断标准,将研究病例划分为Ⅰ型、Ⅱ型精神分裂症。
    Method:Eighteen negative schizophrenia and 15 positive schizophrenia were treated with clozapine,11 negative schizophrenia and 13 positive schizophrenia were treated with risperidone,negative symptoms,positive symptons,cognitive function were assessed separately before and after treatment.
    方法 :对 18例阴性精神分裂症和 15例阳性精神分裂症采用氯氮平治疗 ; 对 11例阴性精神分裂症和 13例阳性精神分裂症采用利培酮治疗。
 

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