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    The positive rate and staining intensity of p53 and bcl 2 oncoprotein in adenoma and adenocarcinoma were significantly higher than in non tumor mucosa( P <0.01),their staining intensity in adenocarcinoma was higher than that in adenoma( P <0.01).
    p53和bcl-2蛋白的表达率和表达强度,腺癌和腺瘤高于非肿瘤粘膜(P<0.01),腺癌的表达强度也高于腺瘤(P<0.05)。
    Results The density of apoptotic cells in adenoma and adenocarcinoma was significantly higher than that in nontumor mucosa( P <0 01),and their density in adenoma was higher than in adenocarcinoma( P <0.01).
    结果腺瘤和腺癌中的凋亡细胞密度均显著高于非肿瘤粘膜(P<0.01); 腺瘤高于腺癌(P<0.01)。
    The densities of p53 protein positive cells in malignant areas of adenomas and adenocarcinomas were significantly higher than those in benign areas of adenomas and non-tumor mucosas respectively (all P< 0.01).
    腺癌及腺瘤恶变区p53蛋白阳性细胞密度均高于腺瘤非恶变区(P<0.01)及非肿瘤粘膜(P<0.01)。
    Results: The densities of apoptotic cells in benign areas of malignantly changed adenomas was significantly higher than those in adenocarcinomas (P<0.01) malignant areas of adenomas (P<0.01) tubular and villous adenomas (P<0.01) and nontumor mucosas (P<0.01), respectively.
    结果 :腺瘤非恶变区凋亡细胞密度分别高于腺癌、管状绒毛状腺瘤及非肿瘤粘膜 (P均<0.01)。 腺癌及腺瘤恶变区p53蛋白阳性细胞密度分别高于管状绒毛状腺瘤 (P均<0.01)和腺瘤非恶变区 (P均<0.01)及非肿瘤粘膜 (P分别<0.01)。
    Results The expression of Fhit protein was positive in 23/53 (43.4%) cases of cancer tissue and in 47/53 (88.7%) cases of adjacent non\|tumoral tissue.
    结果 癌组织Fhit表达为 2 3/ 5 3例 (43.4 % ) ,而癌旁非肿瘤粘膜为 4 7/ 5 3例 (88.7% ) ,相差有非常显著性 (P <0 .0 0 1)。
    Expression and Significance of Epidermal Growth Factor Receptor in Normal Bladder Mucosa of Patients with Bladder Cancer
    表皮生长因子受体在膀胱癌非肿瘤粘膜的表达及意义
    Objective: In order to study the relationship between expression of epidermal growth factor receptor (EGFR) in normal bladder mucosa of patients with bladder cancer and the prognosis of bladder cancer,we used immunohistochemical analysis to detect 64 cases of bladder cancer and 6 cases of normal bladder.
    目的:应用S-P 免疫组化方法对64 例膀胱癌非肿瘤粘膜和6 例正常膀胱粘膜的表皮生长因子受体表达状况进行研究,探讨膀胱癌非肿瘤粘膜表皮生长因子受体的表达与膀胱癌预后是否具有相关性。
 

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