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non-squamous
    Patients with extensive mediastinal lymph node metastasis, more node metastasis and non-squamous carcinoma showed significantly higher incidence of brain metastasis than those with limited mediastinal lymph node metastasis, fewer positive mediastinal lymph nodes and squamous carcinoma (P=0.000, P=0.000, P=0.013).
    多个区域纵隔淋巴结转移、多个纵隔淋巴结转移以及非鳞癌患者的脑转移发生率显著高于单区域纵隔淋巴结转移、纵隔淋巴结转移数目较少以及鳞癌患者(P=0.000,P=0.000,P=0.013)。
    Conclusion High risk factors of brain metastasis in LANSCLC patients after complete resection of the cancer include non-squamous carcinoma, extensive and more mediastinal lymph node metastasis.
    结论局部晚期NSCLC术后脑转移高危因素有:非鳞癌、纵隔多区域淋巴结转移、纵隔多个淋巴结转移。
    In this study, the serum level of squamous cell carcinoma antigen(SCCAg) was measured using IMx system by micropartical enzyme immunoassay(MEIA) method in 105 subjects,including 25 healthy pereons(N1), 20 benign pulmonary disease(BPD), 26 patients with non-squamous cell carcinoma(non-SCC) of lung and 34 patients with squamous cell carcinoma(SCC) of lung.
    本实验采用全自动快速荧光酶分析系统(IMx),用微粒子酶免疫测定法(MEIA)测定了105人血清鳞状细胞癌抗原(SCCAg)水平,其中34例肺鳞癌(SCC),26例肺非鳞癌(NSCC)患者血清SCCAg水平,以20例肺良性疾病和25例健康人为对照组。
    The number of the risk factors(blood g roup B and non-squamous )were neg atively related to prog nosis acc ording to multivariate analysis in s tag e Ⅲa NSCLC(the 5-year survival rates:43.5%vs 23.7%vs 4.0%,P<0.001).
    随着预后不良因素(非鳞癌和B型血)的增加,Ⅲa期患者5年生存率相应呈下降的趋势(43.5%vs23.7%vs4.0%,P<0.001)。
    There was a significant relationship in both abnormal expressions between non-squamous cell cancer (non-SqCC) and non-smokers, but not between SqCC and smokers.
    两者的异常表达在非鳞癌 (non -SqCC)和非吸烟的肺癌者中明显相关 ,而在肺鳞癌和吸烟者中无相关性。
    Methods The expression of p63 and CK5/6 protein was identified by using Elivision's immunohistochemical essay in the paraffin embed tissue sections of 102 cases of squamous cell carcinomas and 98 cases of non-squamous cell carcinomas respectively.
    方法 采用免疫组织化学EliVision法检测10 2例鳞癌和98例非鳞癌组织p6 3和CK5 / 6蛋白表达。
    The difference between two groups was statistically significant(χ 2=50.29,P<0.01). The coexpression of p63 and CK5/6 protein were found in 39.2%(40/102) of squamous cell carcinomas and 3.1%(3/98) of non-squamous carcinomas respectively. The difference between two groups was statistically significant(χ 2=38.71,P<0.01).
    p6 3和CK5 / 6蛋白在鳞癌和非鳞癌组织联合表达率分别为39 .2 % (40 / 10 2 )和3 .1%(3/ 98) ,前者高于后者(χ2 =38 71,P <0 . 0 1)。
    (2) Young patients (≤35 year old) had higher ratios of non-squamous, poorly differentiated and late stage (Ⅲ-Ⅳ) cancers, with a higher rate of lymphatic metastasis compared with other ages.
    (2)年轻宫颈癌患者(≤35岁)与其他年龄组比较,具有非鳞癌和低分化比例高、淋巴结转移率高和晚期(Ⅲ~Ⅳ期)比例高等特点。
    Rusults:Levels of serum SccAg between Nasopharyngeal squamous cell carcinoma and nasophatyngeal non-squamous cell carcinoma were not significant,and comparable to those in controls.
    结果 :鼻咽癌鳞癌及非鳞癌患者血清 Scc Ag水平无明显差异 ,两者与对照相比 ,差异显著。
    The most common histological type was squamous cell carcinoma (71.2%)in study group,while the percentage of non-squamous cell carcinoma (43.8%)in patients younger than30years was much higher than control group(P<0.05). All the histological type was non-squamous cell carcinoma in the patients younger than25years.
    组织学类型以鳞癌为主(71.2%),30岁以下患者非鳞癌比例高于对照组(P<0.05),25岁以下患者都是非鳞癌;
    Among the variables,clinical stage(Ⅱb),tumor size(≥4 cm),histological type (non-squamous carcinoma),poor differentiation,deep stromal invasion,parametrial extension,vaginal margin involved,and lymphvascular permeation were the poor prognostic factors in univariate survival analysis ( P <0.05).
    单因素分析结果显示临床分期Ⅱb ,宫颈肿瘤巨大 ,非鳞癌组织类型 ,低分化 ,深肌层浸润 ,宫旁浸润 ,阴道残端有癌残留 ,脉管有癌栓的患者预后不良 (P <0 0 5 )。
    The tumor stage, pathological type and rate of lymph node metastasis were all significantly different among different age groups (P<0.05). In particular, the young (≤35 years old) group had evidently higher ratios of non-squamous and advanced stage (Ⅲ-Ⅳ) cancers with a higher rate of lymphatic metastasis in comparison with other age groups (P<0.01, respectively).
    不同年龄组病例的临床分期、病理类型及淋巴结转移率比较,差异均有统计学意义(P<0.05),尤其是年轻人宫颈癌与其他年龄组比较,具有非鳞癌比例高、淋巴结转移率高和临床晚期(Ⅲ~Ⅳ期)比例高等显著特点。
    Conclusions The average age of cervical carcinoma onset gradually decreased and simultaneously the ratio of clinically early (stages Ⅰ-Ⅱ) and non-squamous cancer also steadily increased over the last 50 years.
    结论近50年宫颈癌的发病具有明显年轻化、及临床早期比例和非鳞癌比例逐步升高的趋势。
 

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