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non-squamous
    Patients with extensive mediastinal lymph node metastasis, more node metastasis and non-squamous carcinoma showed significantly higher incidence of brain metastasis than those with limited mediastinal lymph node metastasis, fewer positive mediastinal lymph nodes and squamous carcinoma (P=0.000, P=0.000, P=0.013).
    多个区域纵隔淋巴结转移、多个纵隔淋巴结转移以及非鳞癌患者的脑转移发生率显著高于单区域纵隔淋巴结转移、纵隔淋巴结转移数目较少以及鳞癌患者(P=0.000,P=0.000,P=0.013)。
    Conclusion High risk factors of brain metastasis in LANSCLC patients after complete resection of the cancer include non-squamous carcinoma, extensive and more mediastinal lymph node metastasis.
    结论局部晚期NSCLC术后脑转移高危因素有:非鳞癌、纵隔多区域淋巴结转移、纵隔多个淋巴结转移。
    In this study, the serum level of squamous cell carcinoma antigen(SCCAg) was measured using IMx system by micropartical enzyme immunoassay(MEIA) method in 105 subjects,including 25 healthy pereons(N1), 20 benign pulmonary disease(BPD), 26 patients with non-squamous cell carcinoma(non-SCC) of lung and 34 patients with squamous cell carcinoma(SCC) of lung.
    本实验采用全自动快速荧光酶分析系统(IMx),用微粒子酶免疫测定法(MEIA)测定了105人血清鳞状细胞癌抗原(SCCAg)水平,其中34例肺鳞癌(SCC),26例肺非鳞癌(NSCC)患者血清SCCAg水平,以20例肺良性疾病和25例健康人为对照组。
    The number of the risk factors(blood g roup B and non-squamous )were neg atively related to prog nosis acc ording to multivariate analysis in s tag e Ⅲa NSCLC(the 5-year survival rates:43.5%vs 23.7%vs 4.0%,P<0.001).
    随着预后不良因素(非鳞癌和B型血)的增加,Ⅲa期患者5年生存率相应呈下降的趋势(43.5%vs23.7%vs4.0%,P<0.001)。
    There was a significant relationship in both abnormal expressions between non-squamous cell cancer (non-SqCC) and non-smokers, but not between SqCC and smokers.
    两者的异常表达在非鳞癌 (non -SqCC)和非吸烟的肺癌者中明显相关 ,而在肺鳞癌和吸烟者中无相关性。
    Methods The expression of p63 and CK5/6 protein was identified by using Elivision's immunohistochemical essay in the paraffin embed tissue sections of 102 cases of squamous cell carcinomas and 98 cases of non-squamous cell carcinomas respectively.
    方法 采用免疫组织化学EliVision法检测10 2例鳞癌和98例非鳞癌组织p6 3和CK5 / 6蛋白表达。
    The difference between two groups was statistically significant(χ 2=50.29,P<0.01). The coexpression of p63 and CK5/6 protein were found in 39.2%(40/102) of squamous cell carcinomas and 3.1%(3/98) of non-squamous carcinomas respectively. The difference between two groups was statistically significant(χ 2=38.71,P<0.01).
    p6 3和CK5 / 6蛋白在鳞癌和非鳞癌组织联合表达率分别为39 .2 % (40 / 10 2 )和3 .1%(3/ 98) ,前者高于后者(χ2 =38 71,P <0 . 0 1)。
    (2) Young patients (≤35 year old) had higher ratios of non-squamous, poorly differentiated and late stage (Ⅲ-Ⅳ) cancers, with a higher rate of lymphatic metastasis compared with other ages.
    (2)年轻宫颈癌患者(≤35岁)与其他年龄组比较,具有非鳞癌和低分化比例高、淋巴结转移率高和晚期(Ⅲ~Ⅳ期)比例高等特点。
 

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