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急性期
    THE CHANGE OF HUMORAL IMMUNE, ACUTE PHASE PRO- TEINS AND URINE PROTEINS IN CHILDREN WITH NEPHROTIC SYNDROME
    儿童肾病综合征体液免疫、急性期蛋白及尿液蛋白成分变化
    Transcription level of Foxp3, CTLA-4 and GlTR was significantly down-regulated in acute phase of Kawasaki disease ( P < 0.01) , and up-regulated to some extent treated with IVIG ( P < 0.01).
    急性期KD患儿外周血CD4+ T细胞中Foxp3、CTLA-4和GITR基因mRNA表达水平均明显低于正常对照组(P<0.01),IVIG治疗后均有不同程度的恢复(P<0.01);
    Expression of co-stimulatory molecules in monocyte/macrophage during acute phase of Kawasaki disease, such as CD80 and CD86, was higher than those of control group ( P < 0.01) , and down-regulated significantly after treatment with IVIG ( P < 0.01).
    急性期KD患儿CD14+细胞明显过度表达CD80及CD86等共刺激分子(P<0.01),IVIG治疗后CD80及CD86表达均显著下降。
    Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of IL-10 and TGF-β1 in the serum of 12 healthy children as normal controls and 26 patients of acute stage as acute stage MPP group,9 of acute stage MPP group in recovery stage as recovery stage MPP group.
    方法采用双抗体夹心酶联免疫吸附法(ELISA)测定26例MPP急性期和其中恢复期9例患儿及12例健康儿童血清IL-10、TGFβ-1水平。
    Results IL-10 level in acute stage MPP group was significantly lower than that in normal controls(P<0.01); the levels of TGF-β1 in both acute stage and recovery stage MPP group were significantly higher than that in normal controls(Pa<0.01).
    结果MPP急性期及恢复期患儿血清IL-10水平均显著低于对照组(P<0.01,0.05),急性期及恢复期MPP患儿血清TGFβ-1均明显高于对照组(Pa<0.01)。
    There were no significant differentes of the levels of IL-10 and TGF-β1 between acute stage MPP group and recovery stage MPP group.
    MPP患儿急性期与恢复期IL-10、TGFβ-1无明显差异(Pa>0.05)。
    Acute stage was course of disease from 1 to 9 days,and restoration stage was in cure from 8 to 20 weeks.
    急性期为病程d1~9,恢复期为愈后8~20周。
    There are no relations between MPP of infant and PHF-AH genotype,but there is a downward trend in activity of PHF-AH in acute stage.
    婴幼儿MPP发病与PAF-AH基因型无关,但急性期PAF-AH酶活性有下降趋势。
    Results Levels of MMP-2, -9,TIMP-1 and ratios of MMP-2/ TIMP-1,MMP-9/TIMP-1 rose in acute phase of HSPN. The levels and ratios in HSPN group were higher than those in simple purpura group,and those in simple purpura group higher than those in controls (P<0.01 or <0.05).
    结果过敏性紫癜(HSP)患儿急性期血清MMP-2、-9和TIMP-1水平及MMP-2、-9/TIMP-1比值均增高,且HSPN组高于单纯紫癜组,单纯紫癜组高于健康对照组,组间差异具有显著性意义(P<0.01或<0.05)。
    Methods Forty-seven bronchopneumonia patients in their acute phase were divided into three groups:group A1,severe pneumonia complicated by acute congestive heart failure without congenitive heart disease(CHD)(n=15);
    方法选择本院儿科住院肺炎患儿47例,其中支气管肺炎急性期并心力衰竭(无先天性心脏病)患儿15例(A1组);
    Plasma ADM,ET-1 levels of patients in acute phase(pre-treatment)and convalescent phase and controls were measured by specific radioimmunoassary.
    采用特异性放射免疫分析法测定肺炎患儿急性期(治疗前)、恢复期及健康对照儿童血浆ADM、ET-1水平。
    Results 1.The plasma ADM levels significantly increased in the acute phase of A1,B1 and C1 compared with healthy controls(Pa<0.01).
    结果1.急性期血浆ADM水平:A1、B1、C1组均较D组明显升高(Pa<0.01);
    Results①The platelet parameter of severe pneumonia-group and mild pneumonia-group in acute stage was significantly higher than those of control-groups(P<0.05~0.01).
    结果①重症肺炎组与轻症肺炎组急性期4项血小板参数比对照组均显著升高(P<0.05~0.01)。
    ②Severe pneumonia group' s and mild pneumonia group' s 4 platelet parameter in convalescene stage were lower than those in a acute stage(P<0.05~0.01).
    ②重症肺炎组与轻症肺炎组恢复期4项血小板参数比急性期均显著降低(P<0.05~0.01)。
    ③Severe pneumonia' s 4 platelet parameters were significantly higher than mild pneumonia group in acute stage (P<0.01).
    ③重症肺炎组急性期4项血小板参数比轻症肺炎组急性期显著升高(P<0.01)。
    The serum concentrations of LDH, CK, ALT, AST, ALP, GGT, triglycerides (TG) and fibrinogen (FIB) were detected by biochemistry assay. Results The levels of serum LDH, CK, ALT, AST and ALP in acute phase were significantly higher than those in the period of remission (P<0.01).
    方法分析32例儿童感染相关性噬血细胞综合症患儿病情在急性期和治疗缓解期血清LDH、CK、ALT、AST、ALP、GGT浓度的变化,并将这些酶浓度的变化与甘油三脂(triglycerides,TG)、纤维蛋白原(fibrinogen,FIB)浓度的变化进行比较。
    Results The plasma levels of Eotaxin were significantly increased in patients with asthma at the acute period compared with the control group(P<0.01)and intermission group(P<0.01);
    结果哮喘患儿急性期血清中Eotaxin高于对照组(P<0.01)及间歇组(P<0.01),间歇期也高于对照组(P<0.05)。
    and significantly increased at intermission group compared with the control group(P<0.01). The plasma levels of SIcAm-1 were significantly increased in patients with asthma at the acute period compared with the control group(P<0.01)and intermission group(P<0.01);
    哮喘患儿急性期血清中SIcAm-1高于对照组(P<0.01)及间歇组(P<0.01),间歇期也高于对照组(P<0.05)。
    Results The levels of increasing PLT and decreasing PDW in children with acute KD were higher than that in control group(P<0.05).
    结果KD患儿急性期PLT升高,PDW下降均较对照组有统计学差异(P<0.05).
    Methods The 56 cases in MPP group were diagnosed and selected from patients in hospital from June to October 2005,including 33 cases in acute stage and 23 cases in recovery stage.
    方法2005年6月至2005年10月诊断为MPP的住院患儿56例,其中急性期病人33例,恢复期病人23例,正常体检儿童13例作为对照组。
 

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