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亲和性
    Fragment DD2 appeared in the high affinity transmitter group was similar to 5-hydroxytryptamine receptor 1D(5-HTR1D) gene.
    得知DD2序列为高亲和性灰飞虱群体所特有,该序列与人类5-羟色胺受体1D(HTR1D)部分基因同源性高达98%。
    Fragment DD3 appeared in the high affinity transmitter group was similar to gyrase B gene.
    来自高亲和性群体的DD3序列与大肠杆菌的旋转酶B部分基因有着100%的同源性。
    kinetic studies showed a saturable exponential curve correlation between LDL receptor activities and ~(125)I-LDL concentrations in medium. The maximal high affinity binding of a normal human (B max) at 37℃ was 280 ng ~(125)I-LDL/mg cell protein and the appar ent K mvalue 20 μg/ml.
    动力学研究证实受体功能与培养液中~(125)I-LDL浓度呈可饱和性指数曲线关系,一例正常人纤维母细胞37℃时的最大高亲和性结合为280ng/mg细胞蛋白,达到半数最大结合量所需~(125)I-LDL的浓度为20ng/ml。
    The maximal bindingcapacity(Bmax) for high and low affinity binding site was 28. 29±5. 98 fmol/mgprotein and 68. 64±12. 58 fmol/mg protein, respectively.
    低亲和性M受体结合部位的Kd=16.29±3.89nM,Bmax=68.64±12.58fmol/mg蛋白质。
    These virus strains had affinity with the immune serum of strain D78 of IBD virus according to the observation using immunoelectronmicroscope.
    免疫电镜观察,病毒和 IBD 的 D_(78)株免疫血清有亲和性
    The molecular weight was about 70,000. The amino acid analysis showed that the LN receptor was composed of 38% of hydrophobia amino acids and among the hydrophilic amino acids 23.5% were made of Thr, Ser and Asp (including Asn). Nitrocellulose disk assay demonstrated that the binding of HRP-LN to the LN receptor was specific, saturable, and high in affinity(Kd = 0.95 ×10-9mol/L).
    氨基酸组成中疏水氨基酸占38%,苏氨酸、絲氨酸、门冬氨酸(包括门冬酰胺)占23.5%,通过硝酸纤维素膜片法用HRP-LN测定受体与LN的结合特性,证明具有配基结合专一性,饱和性及高亲和性(Kd=0.95×10~(-9)mol/L)。
    Some kinds of receptors possess two affinity binding sites, they belong to the complex ligand-binding system.
    某些受体存在着亚型或异质型,即对某种配基存在有亲和性不同的结合部位,属复杂配基—结合系统。
    The resting Jurkat cells didn't express any high affinity IL- 2 receptor. However, after 24h PMA (20ng/ml) stimulation curkat cells expressed high affinity IL-2 receptors (509 sites/cell, KD 381PM) .
    静止的Jurkat细胞不具有任何亲和性的IL-2结合受体,PMA(20ng/ml)刺激24h后,每个细胞表面表达509个高亲和性IL-2受体,KD值为381PM。
    (2) it seemed to be that the high affinity GTP binding sites which were sensitive to NEM modulated the activity of adenylate cyclase;
    ②高亲和性结合位点(对NEM敏感)调节腺苷酸环化酶活性,而对NEM相对不敏感的低亲和性位点则不直接参与该酶活性的调节;
    The resulte showed that at 4 hours after coronary ligation the quantity and the affinity of α_1-adrenoceptor binding to ~(125)I-BE were not changed in ischemic area. But in the ischemic tissues only one subtype—α_(1b) was left, in contrast to the control tissues in which both subtypes —α_(1a) and α_(1b) existed.
    结果显示左冠状动脉结扎后4小时,缺血心肌的α_1受体与~(125)I-BE结合的数量与亲和性不变,但由对照时含有α_(1a)与α_(1b)两种亚型转变为只含α_(1b)一种亚型。
    In isolated perfusion heart: 30 min suspension of perfusion caused no change of α_1-adrenoceptor and its subtypes. Thirty rain suspension of perfusion following 15 min reperfusin, however, caused decrease of affinity of α_1-adrenoceptor to ~(125)I-BE and turnover from α_(1a) subtypeto α_(1b) subtype.
    离体灌流心脏停灌30min后α_1受体及其亚型均无显著改变,当停灌30min后再重灌15min时虽然α_1受体的数量不变,但与~(125)I-BE结合的亲和性下降,同时也发生α_(1a)亚型向。 α_(1b)亚型的转换。
    Two-site analysis of inhibition of specific~(125)I-BE binding by WB4101 showed there existed high affinity site (a_1 subtype) and low affinity site (a_(1b)subtype). The a_(1a) subtype accounted for 28.5% of the total a_1-adrenoceptor in the control group, but itincreased to 39.5% in the training group.
    WB4101竞争抑制曲线显示大鼠心肌中的α_1受体可分成与WB 4101 高亲和性的α_(1a)亚型与低亲和性的α_(1b)亚型,训练组心肌中α_(1a)亚型所占比例由对照组的28.5%增加到39.5%。
    Adsorption affinity of silicalite-1 to saturated hydrocarbons is stronger than that of unsaturatedhydrocarbons.
    硅沸石Silicalite-1对饱和烃吸附的亲和性强于不饱和烃。
    The two broadly compatible varieties of02428 and CA 529 showed a certain selectivity in their affinity.
    广亲和品种02428,CA529的亲和性具有一定的选择性。
    T-AK cells killed the related target cells whose STA costimulated them with high affinity,and also killed NK-sensitive and NK-resistant target cells. These results suggest that non-MHC-restricted CD8' cytotoxic T cells could be induced by STA and anti-CD3' McAb costimulation.
    T-AK细胞对刺激它的STA来源的靶细胞高亲和性杀伤,杀伤率>90%,对NK敏感和不敏感细胞也有杀伤,表现非MHC限制杀伤。
    RESULTS: Two subtypes of muscarinic receptor binding sites, ie, high and low affinity sites with K d of 51 pmol·L -1 and 689 pmol·L -1 in normal gastric mucosa and 40 pmol·L -1 and 1694 pmol·L -1 in gastric ulcer, respectively. K d value of low affinity binding site in gastric ulcer was remarkably higher than that in the normal gastric mucosa.
    结果:正常胃粘膜上存在高、低两种不同亲和性的M受体,解离常数(Kd)值分别为51pmol·L-1和689pmol·L-1,胃溃疡对Kd值分别为40pmol·L-1和1694pmol·L-1,该低亲和性结合点的Kd值较正常时显著增加。
    After rat were given with 0 25% pirenzepine, high affinity binding site with K d of 93 pmol·L -1 and 76 pmol·L -1 , respectively, exist only in gastric mucosa. The low affinity binding site disappeared.
    用0.25%Pir灌饲大鼠后,胃粘膜上仅存在高亲和性的结合点,Kd值分别为93pmol·L-1和76pmol·L-1,而低亲和性结合点消失。
    CONCLUSION: The occurrence of gastric ulcer relates to M 1 muscarinic receptor of low affinity binding site.
    结论:胃溃疡的发生与胃粘膜上低亲和性结合点的M1受体有关。
    RESULTS: Comparing to the D_2 receptor, D_2/AT_1 chimeric receptor had lower affinities for all D_2 receptor antagonists tested (spiperone, haloperidol, ( + )-butaclamol, chlopromazine, clozapine, trifluo-perdazine) and different affinity profiles to agonists ( apomorphine, dopamine, quinpirole, bromo-criptine).
    结果:与野生型D_2受体相比,D_2/AT_1嵌合受体与拮抗剂的亲和性均降低,与激动剂的亲和性有的增高,有的降低.
    As 2 nitroimidazoles,the radiosensitizing activity of a 3 nitrotriazole derivative correlates with its electron affinity,determined as E 1/2 ,half wave reduction potential.
    3-硝基三唑衍生物也像2-硝基咪唑类那样,其放射增敏活性与电子亲和性(用半波还原电位E1/2表示)有关。
 

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