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肌肽
    Carnosine Zine Complex
    抗溃疡药——肌肽锌(Z-103)
    Objective To investigate the effect of carnosine on the concentration of malondialdehyde(MDA),expression of heat shock protein 70(HSP70)and inflammatory factor after ischemia-reperfusion injury(IRI)in a Wistar rat model of ischemia-reperfusion injury.
    目的通过失血性休克大鼠血液回输后造成的缺血-再灌注损伤(IRI)模型,研究肌肽对IRI后丙二醛(malondialdehyde,MDA)浓度、热休克蛋白70(HSP70)及炎性因子表达水平的影响。
    Conclusion Carnosine administration could promote the expression of HSP70 and suppress the increase of MDA and inflammatory factor mRNA expression.
    结论肌肽可以抑制IRI后MDA的生成、从mRNA水平促进HSP70的表达、抑制炎性因子mRNA的表达。
    In vitro, cell proliferation and the level of IGF-1 were determined by addtion of carnosine (Omg/L, 300mg/L, 500mg/L, 1000mg/L) into the culture medium for liver cell collected from 8-day yellow feather broiler respectively. The effect of carnosine (500mg/L) on the liver cell GHR and IGF-1 gene expression was also studied.
    取8d黄羽肉鸡的肝细胞进行离体培养,检测在培养液中分别添加0、300、500、1000mg/L剂量的肌肤对肝细胞增殖、分泌IGF-1水平的影响,并检测了在培养液中添加500mg/L肌肽对肝细胞GHR、IGF-1基因表达的影响.
    Carnosine at concentration of 500mg/L and 1000mg/L significantly promoted liver cell proliferation(p<0.05).
    在培养液中添加500mg/L、1000mg/L剂量的肌肽对肝细胞的增殖有显著的促进作用(p<0.05).
    At 144h culture period, the level of IGF-1 secretion of carnosine supplementation groups was higher than that of control group, especially carnosine group at concentration 500mg/L had a significant influence on it (p<0.05).
    在144h,添加肌肽的各试验组细胞分泌IGF-1的水平均高于对照组,其中500mg/L剂量组显著性的高于对照组(P<0.05).
    The level of GHR and IGF-1 gene expression could be improved by addtion of carnosine at concentration of 500mg/L into culture medium of in vitro liver cell culture.
    在细胞培养液中添加500mg/L的肌肽可以提高离体培养的鸡肝细胞GHRmRNA、IGF-1mRNA的表达趋势.
    The chicks in the control group were fed with a basic diet. The chicks of the high GSH dosage group and the low GSH dosage group were fed with thr basic diet supplemented with 160 and 80mg/Kg GSH respectively, while the chicks of carnosine group were fed with the basic diet supplemented with 20mg/Kg carnosine.
    A组为对照组饲喂基础日粮,B组为GSH低剂量组饲喂基础日粮+80mg/kg GSH,C组为GSH高剂量组饲喂基础日粮+160mg/kg GSH,D组为肌肽组饲喂基础日粮+20mg/ 肌肽.
    The results demonstrated the following findings:1) Dietary carnosine and GSH supplementation promoted the production performance of yellow feather broilers.
    结果表明:1)日粮添加肌肽、GSH对黄羽肉鸡的生产性能有一定的促进作用.
    Compared with control group, high dosage GSH group, low dosage GSH group and carnosine group improved the average daily gain weight by 2.6%, 4.4% and 1.68% respectively.
    与对照组相比,GSH低、高剂量组、肌肽组的平均日增重分别提高了4.4%、2.6%、1.68%.
    2) The level of IGF-1 in serum was significantly improved by dietary supplementation of either carnosine or GSH (p<0.05). The level of FT3 in serum was significantly improved by dietary GSH supplementation (p<0.05).
    2)在日粮中添加肌肽、GSH可以显著提高黄羽肉鸡血清中的IGF-1水平(p<0.05),同时日粮添加GSH可以显著提高黄羽肉鸡血清中的FT3水平(p<0.05).
    In conclusion that dietary supplementation of carnosine or GSH promoting the growth of yellow feather broilers linked with they significanty improving the level of FT3 and IGF-1 in serum.
    以上结果提示:日粮添加肌肽、GSH能显著提高黄羽肉鸡血清中的FT3和IGF-1含量,能促进黄羽肉鸡生长.
    The result showed that 20uM carnosine Zinc were capable of promoting liver cell proliferation in vitro culture, especially at 48h and 72h ( p<0.05 ) .
    结果表明:结果表明:1)在各个时期,含20uM肌肽锌的试验组肝细胞生长均好于对照组,而且在48h和72h时差异显著(p<0.05);
    Protective effect of carnosine against toxic effects of hydrogen peroxide and β-amyloid(25-35) on PC12 cells
    肌肽对H_2O_2、Aβ_(25-35)诱发PC12细胞损伤的保护作用
    The oxidative carbonyl protein and carnosine protection
    蛋白质氧化羰基化和肌肽的保护作用
    Comparison of anti-oxidation effect between carnosine and mitochondria
    肌肽与细胞线粒体抗氧化作用的比较
    Studies on the anti-fatigue effect of carnosine in mice
    肌肽对小鼠抗疲劳作用的试验研究
    Occurrence of cataract and use of carnosine
    白内障的发生与肌肽
    Effect of carnosine on steroid-induced modification of lens α-crystallin
    肌肽对激素诱导晶状体α-晶状体蛋白修饰的作用(英文)
    Anti-oxidation of Carnosine and it's Pharmaceutical Application
    肌肽的抗氧化性及其在医药上的应用
 

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