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慢性压迫性
    Effect of Hyaluronidase on Neuropathic Pain in Chronic Constriction Nerve Injury Rats
    透明质酸酶对慢性压迫性神经损伤模型中神经源性疼痛的作用研究
    Effects of tramadol on synaptic remodeling in the rat spinal cord after chronic constriction injury of sciatic nerve
    曲马多对慢性压迫性坐骨神经损伤模型大鼠脊髓突触重塑的影响
    The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery.
    目的 :观察电压门控钠通道NaN /SNS2在大鼠坐骨神经慢性压迫性损伤 (chronicconstric tioninjury ,CCI) 14天后的变化 ,探讨慢性神经痛的发生机制。
    Objective:To investigate the changes of phosphorylated p38MAPK expression in DRG neurons in rats with chronic constriction injury (CCI)of sciatic nerve.
    目的:观察背根神经节(DRG)磷酸化的p38丝裂原活化蛋白激酶(p -p38MAPK)在大鼠坐骨神经慢性压迫性损伤(CCI)后表达的变化,探讨慢性神经痛的发生机制。
    AIM: To study the influence of tramadol on synaptic remodeling of astrocytes in the rat spinal cord after chronic constriction injury (CCI) of sciatic nerve.
    目的:探讨曲马多对大鼠坐骨神经慢性压迫性损伤脊髓星形胶质细胞突触重塑的影响。
    Objective: To investigate the effect of intracerebroventricular(i.c.v.) injection of endomorphin-1(EM-1) on IL-6 mRNA expression level in hippocampus and on PAG in chronic constriction injury(CCI) model of rats.
    目的:观察侧脑室微量注射内吗啡肽-1(endomorphin-1,EM-1)对坐骨神经慢性压迫性损伤(chronic constriction injury,CCI)大鼠痛阈以及海马和中脑导水管周围灰质(periaqueductal gray,PAG)中白细胞介素-6(interleukin-6,IL-6)mRNA表达的影响。
    Study of astrocytes and synaptic remodeling in the rat spinal cord after chronic constriction injury of sciatic nerve
    坐骨神经慢性压迫性损伤对大鼠脊髓星形胶质细胞增生和突触重塑的影响
    Immunohistochemical changes of synaptophysin in the rat spinal cord after chronic constriction injury of sciatic nerve and ketamine intervention study
    大鼠坐骨神经慢性压迫性损伤脊髓突触体素的变化
    AIM:It has been studied that ω conotoxin SO3 and SNX 111 are similar in the ir structure. In this study,we investigated the effects of ω conotoxin SO3 or S NX 111 through subarachnoid injection on pain related behaviors in rats with ne uropathic pain induced by chronic constriction injury(CCI).
    目的:有研究显示ω-芋螺毒素SO3与SNX-111结构相似,探讨蛛网膜下腔注射ω-芋螺毒素SO3或SNX-111对慢性压迫性损伤后神经痛的大鼠痛行为的影响。
    Objective To study the changes of synaptophysin in the rat spinal cord after chronic constriction injury of sciatic nerve and the influence of ketamine intervention.
    目的探讨坐骨神经慢性压迫性损伤大鼠脊髓突触体素(p38)变化及氯胺酮干预的影响。
    Methods Twenty-four female SD rats weighing 180-250 mg were divided randomly into 4 groups (n=6 in each group). Group I:The right sciatic nerve chronic constriction injury (CCI) model was established.
    方法将24只SD雌性大鼠随机分为4组,I组:制备坐骨神经慢性压迫性损伤(CCI)模型;
    Objective To study the changes of astrocytes and synaptic remodeling in the rat spinal cord after chronic constriction injury (CCI) of sciatic nerve.
    目的探讨坐骨神经慢性压迫性损伤大鼠脊髓星形胶质细胞变化及其与突触重塑的关系。
    Objective: To investigate the changes of c-jun in dorsal root ganglion(DRG) neurons in chronic constriction injury(CCI) model of chronic neuropathic pain.
    目的观察大鼠背根神经节(DRG)中即刻早期基因(IEG s)c-jun在慢性压迫性损伤(CC I)疼痛模型中的变化,探讨慢性神经痛的发生机制。
    Objective To determine whether chronic constriction injury (CCI) to sciatic nerve is associated with changes in the phosphorylation of CREB in dorsal root ganglia ( DRG) and superficial dorsal horn neurons of the spinal cord.
    目的探讨背根神经节和脊髓背角磷酸化cAMP反应元件结合蛋白(pCREB)表达在慢性压迫性神经损伤(CCI)致神经病理性疼痛大鼠痛觉过敏中的作用。
    AIM: To observe the long-term analgesic effect of continuous intrathecal injection of ω-conopeptide SO3 on neuralgia induced by chronic constriction injury CCI in rats, and evaluate the side effect which maybe occur.
    目的:观察持续鞘内注射ω-芋螺毒素SO3对慢性压迫性损伤所致的神经痛大鼠的长期镇痛效果及其可能出现的副作用。
    Aim To evaluate the effect of continuous intrathecal administration of omega-conotoxin SO3 on a model of neuropathic pain and the down-regulation of serum concentration of IL-6 in a rat model of chronic constriction injury.
    目的观察持续鞘内注射新型特异性N型电压依赖性钙通道阻滞剂—ω-芋螺毒素SO3对慢性压迫性损伤所致的神经痛大鼠的长期镇痛效果,及其对神经痛大鼠血清IL-6浓度的影响。
    Methods Chronic constriction injury (CCI) model was adopted. Mechanical withdrawal threshold and thermal withdrawal latency were measured and P2X_3 immunoreactivity in L_4/L_5 spinal cord was detected by immunohistochemistry.
    方法建立大鼠坐骨神经慢性压迫性损伤(CCI)神经病理痛模型,应用vonFrey细丝法和热辐射法测定机械缩足反射阈值(mechanical withdrawal threshold,MWT)和热缩足反射潜伏期(thermal withdrawal latency,TWL),观察川芎嗪对CCI大鼠MWT和TWL的影响。
 

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