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    A OUASILINEAR MODEL FOR ANALYSING DATA OF CROSSOVER TRIALS
    交叉试验设计分析的拟线性模型
    Methods:Twenty male healthy volunteers received 2mg finasteride tablet orally in a random crossover design.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂2mg,用LC-MS法测定国人血浆中的非那雄胺浓度。
    METHODS: The study was conducted as a 3- way crossover design in 18 healthy volunteers whose plasma concentrations of cefixime were determined by HPLC after receiving a single oral dose of 200 mg trial preparations or reference preparation.
    方法:采用高效液相色谱法测定18名健康受试者三交叉单剂量口服受试制剂或参比制剂200mg后血浆中头孢克肟的浓度。
    Methods Twenty healthy male volunteers received 200 mg nevirapine tablets orally in a random crossover design. Drug concentrations in the plasma were determined by HPLC.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂200 mg,用HPLC法测定血浆中的奈韦拉平浓度。
    Methods A single oral dose (100 mg of tested and reference formulation) were given to 20 healthy volunteers in a randomised crossover study.
    方法健康志愿者20名,随机双交叉单剂量口服盐酸舍曲林分散片和片剂100mg,分别于服药后120h内多点抽取静脉血;
    Methods Twenty male healthy volunteers received 2 mg finasteride tablet orally in a random crossover design.
    方法采用随机双交叉试验设计,20名健康受试者口服受试制剂和参比制剂2mg,用LC-MS法测定人血浆中的非那雄胺浓度。
    A single oral dose 10 mg lomerizine hydrochloride capsule or tablet was given to 20 healthy volunteers according to an open randomized crossover study. The concentration of lomerizine hydrochloride in plasma was determined by HPLC-MS method, and the relative bioavailability of AUC0~24 was 103.4%±15.6%.
    20名男性健康志愿者单剂量随机交叉口服盐酸洛美利嗪胶囊(10mg)和参比制剂盐酸洛美利嗪片(10mg),经HPLC-MS法测定盐酸洛美利嗪的血药浓度,受试制剂的相对生物利用度为103.4%±15.6%。
    METHODS A single oral dose of two preparations was given to 20 healthy male volunteers according to a randomized crossover design.
    方法采用随机二交叉设计试验,20例男性健康志愿受试者,单剂量口服受试制剂和参比制剂的马来酸依那普利片。
    OBJECTS: To study the pharmacokinetics of gatifloxacin test and reference in a two-way crossover design experiments and to evaluate their bioequivalence.
    目的:进行加替沙星试验制剂与参比制剂的单剂两周期交叉试验,评价加替沙星的药代动力学特征,以及两制剂的生物等效性。
    METHODS Sixteen healthy volunteers were given medicine 60mg in oral by an open randomized crossover design.
    方法:健康志愿者16名随机交叉口服给药60mg。
    Methods A randomized, self-control, crossover design was adopted. The wash-out period was 7 days.
    方法采用随机分组、自身交叉对照设计,清洗期7d。
    METHOD According to an open randomized crossover study, the Beagle dogs were iv or ig a single dose of 5mg HZ08, respectively. The concentrations of HZ08 in dog plasma were determined by LC-MS/MS with positive ion SRM detection using drotaverine as internal standard.
    方法6只Beagle犬进行随机双交叉试验,分别单剂量静脉注射或灌胃HZ08,采用液相色谱串联质谱(LC-MS/MS)以屈他维林为内标正离子选择性反应检测测定给药后血浆中的药物浓度,计算两者的药动学参数及绝对生物利用度。
    METHODS In a randomized crossover study, 20 healthy male volunteers were given a single oral dose of 400 mg ibuprofen plus 500 mg acetaminophen(reference)and 400 mg/325 mg ibuprofen/ acetaminophen(test). Ibuprofen and acetaminophen in plasma were determined by a LC-MS/MS method and HPLC-UV method.
    方法20名健康男性受试者按照随机交叉试验设计分别口服单剂量布洛芬软胶囊(布洛芬400mg,参比制剂)和对乙酰氨基酚片(对乙酰氨基酚500mg,参比制剂)与复方布洛芬软胶囊(布洛芬400mg和对乙酰氨基酚325mg,受试制剂),LC-MS/MS法和HPLC-UV法测定血浆中布洛芬和对乙酰氨基酚的浓度。
    marketedcapsule and marketed injection in a randomized crossover way. A two-compartment open model was adopted. Calculated areas under curve(AUC) were 2105 ug/ml-min 1344.31 ug/ml*min and 1456.7ug/ml*min with respective of sustained-release tablet (300mg).
    动力学特征符合二室模型,普通胶囊(300mg)和缓释片(300mg)的曲线下面积(AUC)分别为1344.31ug/ml~*min和2105ug/ml~*min;
    The plasma concentration of melatonin of 6 Beagle dogs was determined by HPLC and the pharmacokinetic parameters were caculated with drug and statistic (DAS) softerware after administered random crossover with single dose of 6mg conventional tablets or orally disintegrating tablets.
    6条Beagle犬单剂量交叉口服褪黑素口腔崩解片和普通片6mg后,用高效液相色谱法测定血浆药物浓度,用DAS软件计算药动学参数。
    The bioavailability of zinc gluconate granules was compared withzinc sulfate syrup in six healthy volunteers in a two-way crossover design. Nosignificant difference was observed in the parameters of t_m,C_m,AUC_(0-3),andAUC_(0-5) between the two preparations.
    对6名健康志愿者用交叉实验设计比较了葡萄糖酸锌冲剂与硫酸锌糖浆的生物利用度,结果两种制剂的 t_m、C_m、AUC_(0-3)及 AUC_(0-5)等参数无显著差异。
    The plasma drug levels of eight healthy volunteers following oral administration (20mg) of conventional and controlled-release piroxicam tablets in a crossover design were determined.
    本文应用高效液相色谱法测定了8名健康受试者自身交叉服用炎痛喜康普通片与控释片(分别服用单剂量20mg)后的血药浓度。
    Observation of the adverse reaction of lorcainide hydrochloride in 20 persons (12 patients with arrhythmia, 100 mg, bid po for 1 wk; 8 Volunteers crossed 100 mg or 200 mg on single dose po) by randomized double-blind and crossover test with placebo as control. The serum concentration of this drug was detected in 18 persons by HPLC method.
    双盲法口服盐酸劳卡胺20例(12例心律失常患者,100mg,bid×1wk;8例健康志愿者以100mg或200mg交叉单剂量口服),观察服药后不良反应发生情况,并以HPLC法测定其中18例血药浓度。
    8 healthy male volunteers were administered a single oral dose of 200mg domestic bepridil tablet or imported Vascor tablet in two-period crossover design.
    8名健康男性志愿者,按交叉设计单剂量po 200mg国产吡咯地尔片剂和进口Vascor片剂.
    METHOD:A randomized crossover study on the pharmacokinetics of lacidipine tablets at a single oral dose of 12 mg was conducted in 8 healthy volunteers.
    方法:8名健康志愿者,随机交叉,单剂量口服国产和进口拉西地平片12mg,用HPLC测定不同时间的血药浓度,用MCPKP软件进行拟合处理,并计算药动学参数。
 

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