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    CLINICAL ANALYSIS OF DISTANT METASTASES OF 179 NASOPHARYNGEAL CARCINOMA (NPC) PATIENTS
    鼻咽癌远处转移179例临床分析
    A Study on Distant Metustasis of the Carcinoma of the Tongue
    舌癌远处转移的研究
    Results LVD was positively related to lymph node metastasis (P<0.01),clinical staging (P<0.05) and perioneal metastasis(P<0.05). MVD was positive by related to lymph node metastasis(P<0.05),distant metastasis(P<0.01), clinical staging (P<0.05)and peritoneal metastaasis(P<0.05) of the ovarian carcinomas.
    结果LVD与卵巢癌淋巴结转移(P<0.01)、FIGO分期(P<0.05)及腹膜转移(P<0.05)显著正相关,MVD与卵巢癌淋巴结转移(P<0.05)、腹膜转移(P<0.05)、远处转移(P<0.01)及FIGO分期显著正相关(P<0.05)。
    【Conclusion】The combined radiotherapy with thymic peptide can highly improve the survival rate of patients with nasopharyngeal carcinoma and lower its distant metastasis rate.
    【结论】放疗联合胸腺肽治疗能够明显提高鼻咽癌患者的生存率,降低远处转移率。
    Distant metastasis and tumor recurrence were the main death reasons. The overall local recurrence rate was 30.0%,and distant metastasis rate was 26.7%.
    临床分期中Ⅲ期最常见(56.7%),局部复发和远处转移是患者死亡的主要原因,局部复发率为30.0%,远处转移率为26.7%。
    Results The positive rate of E-cadherin in gastric carcinoma was 37.5%, which was significantly lower than that in para-cancerous mucosa (100%, P<0.05). The expression of E-cadherin was significantly related with the differentiated degree, histologic type, depth of tumor invasion, lymph node metastasis and distant metastasis (P<0.05).
    结果胃癌组织E-cadherin的阳性率(37.5%)显著低于癌旁组织(100%)(P<0.05),E-cadherin的表达与胃癌不同分化程度、组织学类型、浸润深度、淋巴结转移、临床分期及远处转移有关(P<0.05)。
    The positive rate of Snail in gastric carcinoma was 83.3%, which was significantly higher than that in para-cancerous mucosa (41.25%,P<0.05). The expression of Snail was significantly related with the differential degree, histologic type, depth of tumor invasion, lymph node metastasis and distant metastasis (P<0.05).
    胃癌组织Snail阳性率(83.3%)显著高于癌旁组织(41.25%)(P<0.05),Snail的表达与胃癌不同分化程度、组织学类型、浸润深度、淋巴结转移及远处转移有关(P<0.05)。
    The expression of FAF1mRNA in gastric cancer was closely correlated with cell differentiation,distant metastasis,but not correlated with age,sex,depth of invasion,stage(TNM),lymph node metastasis and the size of tumor.
    FAF1 mRNA在胃癌中的表达水平与癌细胞分化程度、远处转移有关,而与年龄、性别、浸润深度、临床分期、有无淋巴结转移及肿瘤大小无关。
    Results: The overall 5 year survival rates,local control rate and distant metastasis rate were 42.5%,49.2.0%,20.8%,respectively. Irradiation dose,T stage and reccurrent interval were important prognostic factors for survival rate.
    结果:总的5年生存率、局控率及远处转移率分别为:42.5%,49.2%,20.8%,照射剂量、T分期及复发间隔时间是影响生存率的重要因素。
    Rank sum test was used to analyze the expressions of VEGF, Flk-1. Results:VEGF and Flk-1 expression in CC were positively correlated with depth of invasion, lymph node metastasis, distant metastasis, Dukes' stage .
    结果:VEGF及Flk-1的表达与大肠癌的浸润深度、淋巴结转移、远处转移、Dukes分期呈正相关。 VEGF与Flk-1表达呈正相关。
    The protein expression levels of CCR7 and P-Akt in gastric carcinoma tissues were higher than those of the adjacent normal tissues (P<0.001). The protein expression of CCR7 and P-Akt was related to TNM stage,depth of invasion,differentiation,lymph node metastasis and distant metastasis (P<0.05). CCR7 protein expression was correlated with Akt protein expression (P<0.05).
    CCR7、P-Akt蛋白在胃癌组织中的表达水平明显高于癌旁对照组织(P<0.05),两者表达与肿瘤TNM分期、浸润深度、分化程度、淋巴结转移与远处转移有关(P<0.05),并且CCR7、P-Akt表达水平呈正相关(P<0.05)。
    VEGFR-3 expression in vascular vessels has the significant correlation with venous invasion and distant metastasis,while its expression in lymphatic endothelium has the correlation with VEGF-C expression,lymphatic invasion and lymph node metastasis(P<0.05).
    VEGFR-3在血管内皮的表达(MVD)与静脉浸润和远处转移有关(P<0.05),而在淋巴管内皮的表达(LVD)则与VEGF-C表达、淋巴管浸润和淋巴结转移有关(P<0.05)。
    Results The complete ablation rate was 93.9%,the local recurrence and distant recurrence rates were 9.1% and 33.3%,respectively. One,two-,and three-year disease-free survival rates were 62.6%,62.6% and 62.6%,respectively and overall survival rates were 84.0%、74.5% and 63.9%,respectively.
    结果肿瘤完全消融率为93.9%,局部复发率9.1%,远处复发率33.3%,1年、2年和3年无瘤存活率分别为62.6%、62.6%和62.6%,总存活率84.0%、74.5%和63.9%。
    The 3-year distant metastasis rate and locoregional relapse rate for NSCLC patients with the positive and negative of PBMM were 70% vs 63% (X~2=0.34,P=0.559)and 69% vs 57% (X~2=0.61,P=0.435),respectively.
    外周血微转移阳性和阴性3年远处转移率分别为70%和63%(X~2=0.34,P=0.559); 3年局部复发率分别为69%和57%(X~2=0.61,P=0.435);
    [Conclusion] For primary gastric carcinoma,18F-FDG coincidence imaging is a sensitive method which plays an important role for detecting perigastric lymph node involvement,distant metastasis and preoperative staging.
    [结论]18F-FDG符合线路显像对于胃癌是一种灵敏的检查方法,在胃局部淋巴结转移、远处转移、术前分期方面具有重要的临床意义。
    Thirty-six of all cases were in long-time follow-up and the ratio of follow-up was 69.2%(36/52). Nine cases were recurred in the region,6 cases had distant metastasis and survival rate of 5 years was 61.1%(22/36).
    36例患者经过长期随访,随访率69.2%(36/52),其中局部复发9例,远处转移6例,5年生存率61.1%(22/36)。
    the recurrence rate were 0 and 6.4 %; the distant metastasis rate were 13.3 % and 16.1 %; the 1-year and 3-years survival rate were100 %, 96.7 %, 96.7 %, 87.1 %.
    1、3年肿瘤局部控制率分别为100.0%、93.3%和93.6%、83.9%,复发率分别为0和6.4%,远处转移率分别为13.3%和16.1%;
    The CR+PR and the 1-year and 3-years remission rate and the 1-year and 3-years survival rate were higher in the treatment group, the recurrence rate and the distant metastasis rate were much less in the treatment group, but there were no difference between the two groups (P >0.05).
    1、3年生存率分别为100.0%、96.7%和96.7%、87.1%,治疗组近期有效率及1、3年局部控制率、生存率较高,复发率和远处转移率较低,但两组差异均无统计学意义(P>0.05)。
    The expressions of HIF-1α and survivin were closely related with clinical stage and distant metastasis. The expression of HIF-1α correlated with lymph node metastasis.
    HIF-1α、survivin表达与食管鳞癌临床分期、远处转移密切相关(P<0.05),HIF-1α的表达还与淋巴结转移有关(P<0.05);
    Methods Immunohistochemistry was used to detect the expressions of MMP-9 and TIMP-2 in specimens from 156 patients, including specimens of the carcinoma (99), of surrounding mucosa (16), of distant metastases (16) and of metastastic lymph node (25).
    方法采用免疫组织化学方法检测MMP-9和TIMP-2在99例胃癌、16例癌周黏膜、16例胃癌远处转移灶和25例胃癌淋巴结转移灶标本中的表达情况;
 

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