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    The Study on the Relationship between G1057D Variants of IRS-2 Gene and T2DM
    IRS-2基因G1057D突变与中国汉族人T2DM的相关性
    Pathopoiesis Effects of the Oxidative Stress、OIR on the T2DM and the Regulatory Mechanism of Insulin Related Signal Pathway
    氧化应激、OIR对T2DM大鼠的致病作用及胰岛素相关信号通路的调控机制
    PFD Test in SLE & DM Cases for Determination of Pancreatic Exocrine Function
    胰功肽试验对SLE、DM胰外分泌功能的检查
    DETERMINATION OF PLASMA FREE AMINO ACIDS IN PATIENTS WITH SLE AN D DM
    SLE、DM血浆游离氨基酸的测定
    Observation of erythrocyte immunity and T cell subgroup in DM nephropathy
    糖尿病性肾病红细胞免疫及T细胞亚群的观察
    Results The logarithmic value of U-mAlb/Cr between DM group(1.46±0.83) and NC group(0.42±0.14) had the significant difference(P<(0.01)). There was no significant difference(P>0.05) between men and women of diabetes group.
    结果:糖尿病组尿微量白蛋白/肌酐比值对数值为1.46±0.83,明显高于对照组0.42±0.14(P<0.01),且性别差异无统计学意义(P>0.05)。
    Objective To investigate the relationship of GATA-3、IL-4 and PM /DM.
    目的探讨GATA-3及Th2细胞因子IL-4与多发性肌炎(PM)/皮肌炎(DM)的关系。
    Methods The expression of mRNA of GATA-3、IL-4 in patients of PM/DM was studied with RT-PCR.
    方法用RT-PCR方法检测PM/DM患者外周血单个核细胞(PBMC)中GATA-3、IL-4的mRAN表达,并与正常健康人进行比较。
    Results The positive rate of GATA-3 mRNA in PM /DM was significantly higher than in control(85.7%,86.4% vs 25% P<0.05; the expression intensity of GATA-3 in PM/DM was significantly higher than in control(0.268,0.411vs 0.000) (P<0.05).Conclusions Overdifferentiation of Th2 cell may be related with expression of GATA-3
    结果PM、DM组中GATA-3mRNA表达阳性率(85.7%,86.4%)均高于正常对照组(25%)(P<0.05); PM、DM组GATA-3的表达强度(0.268,0.411)均高于正常对照组(0.000)(P<0.05);
    MMP-9,SBP were independent risk factors of T2DM macroangiopathy,and the high-density lipoprotein cholesterol was a protective factor.
    MMP-9、SBP是T2DM大血管病变的独立危险因素,高密度脂蛋白胆固醇是保护因素。
    Methods Fasting serum adiponectin concentrations were measured with ELISA in 240 cases,including patients 104 with type 2 diabetes(DM group),46 patients with impaired glucose tolerance(IGT group) and 90 controls(NGT group),each group was further divided into two subgroups based on body mass index(BMI).
    方法240例受试者,其中2型糖尿病患者(DM组)104例,糖耐量减低者(IGT组)46例,对照组(NGT组)90例,各组按体质量指数(BMI)分成肥胖和非肥胖亚组,放射免疫法测定胰岛素(FINS);
    ④The genotype GG frequencies in IGT and DM groups were 8.7% and 11.6% respectively,which were significantly higher than those in NGT group.
    ④IGT组、DM组GG基因型频率分别为8.7%和11.6%,显著高于NGT组(4.5%),GG基因型携带者脂联素水平显著降低。
    Objective To study the clinical and coronary angiographic features in patients with acute myocardial infarction(AMI) and type 2 diabetes mellitus(DM).
    目的探讨急性心肌梗死(AMI)合并2型糖尿病(DM)患者的临床特征和冠状动脉病变特点。
    Methods 226 patients with AMI were divided into 45 cases of AMI with type 2 diabetes mellitus (AMI+DM group) and 181 cases of AMI without type 2 diabetes mellitus (AMI group),the clinical and the coronary angiographic data were compared.
    方法226例AMI患者分为AMI并2型糖尿病组(AMI+DM组)45例和AMI非糖尿病组(AMI组)181例,对比分析两组患者的临床和冠状动脉造影资料。
    And had lower blood pressure,TC,TG,Fins and HOMA-IR,and higher HOMA-β than the DM group.
    与糖尿病(DM)组比较,IGR组血压、Fins、TC、TG、HOMA-IR升高的程度不如DM组显著,HOMA-β降低程度较DM组轻。
    Resulus The levels of FPG,FIns,HbA1c,HOMA-IR,hsCRP and IMT in T2DM group were significantly high than those in NGT group (P<0.05 or P<0.01).
    结果T2DM组的FPG、FIns、HbA1c、HOMA-IR、hsCRP和IMT均显著高于NGT组(P<0.05或P<0.01);
    After 12 months’ treatment of Rosiglitazone,all the indexes measured above were decreased significantly in T2DM group (P<0.05 or P<0.01)Conclusion Rosiglitazone can improve their insulin resistance,decrease inflammatory reaction and delay the occurrence,and development of atherosclerosis in type 2 diabetics.
    马来酸罗格列酮治疗后IGT组的上述指标与治疗前相比均显著下降(P<0.05或P<0.01)。 结论马来酸罗格列酮治疗可改善T2DM患者胰岛素抵抗状态,降低炎症反应,并可能缓解动脉粥样硬化的发生和发展。
    Methods:SD rats were randomly divided into NC group,DM group and DV group.
    方法:将SD大鼠随机分成三组:正常对照组(NC组)、糖尿病组(DM组)、糖尿病+缬沙坦干预组(DV组)。
    Results:The BW of diabetic rats in DM and DV groups decreased significantly compared with NC group(P < 0.01), but no notable difference was found in HbA1c and BG between DM and DV group(P > 0.05).
    结果:DM和DV组大鼠体重较NC组明显降低(均P<0.01),DM和DV组间糖化血红蛋白(HbA1c)及血糖无显著性差异(P>0.05);
    The expression of MCP-1 mRNA in DM and DV groups was much higher than that in NC group(P < 0.01), but it was much lower in DV group than that in DM group(P < 0.01).
    DM和DV组大鼠血管组织中MCP-1mRNA的表达明显高于NC组(均P<0.01),而DV组明显低于DM组(P<0.01);
 

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