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    ①At 6 weeks after injury,the bone density of the combined brain injury group was higher than simple fracture group [(0.112±0.024),(0.086 ±0.024)g/cm2,P < 0.05].
    ①致伤后6周合并脑损伤组骨密度高于单纯骨折组[(0.112±0.024),(0.086±0.024)g/cm2,P<0.05]。
    ③The limiting value of anti-bending strength of affected limbs at 6 weeks after injury was greater in the combined brain injury group than simple fracture group [(161.674±10.060),(135.400 ±12.540)kN/cm2,P < 0.05].
    ②致伤后6周合并脑损伤组骨痂直径大于单纯骨折组(P<0.05)。 ③致伤后6周患肢抗弯强度极限值合并脑损伤组大于单纯骨折组[(161.674±10.060),(135.400±12.540)kN/cm2,P<0.05]。
    Finally,the BMD in fracture group was significantly decreased by 1.6-2.5 s as compared with the peak BMD of health women.
    而与同地区正常女性峰值骨量相比,BMD下降1.6~2.5s。
    The allele frequencies of apolipoprotein E4 in the simple osteoporosis group and osteoporotic fracture group were obviously higher that that in the normal control group (χ2=4.904,16.681,P < 0.01),it was also markedly higher in the osteoporotic fracture group than in the simple osteoporosis group (χ2=4.658,P < 0.01).
    ②载脂蛋白E基因4型等位基因频率3组比较差异有非常显著性意义(χ2=17.520,P<0.01),携带载脂蛋白E基因4型频率骨质疏松组及骨质疏松性骨折组明显高于正常人群(χ2=4.904,16.681,P<0.01); 骨质疏松性骨折组高于骨质疏松组(χ2=4.658,P<0.01)。
    Their follow-up periods,ranging from 3 to 7 years,averaged 4.6 years in the intertrochanteric fracture group and 5.5 years in the neck fracture group.
    结果两组随访时间均为3~7年,转子间骨折组平均4.6年,股骨颈骨折组平均5.5年。
    METHODS:The experiment was conducted in the Biochemical Laboratory of Hebei Medical University from October 2003 to February 2005.Totally 84 clean grade adult male SD rats were selected and randomly divided into 4 groups:normal control group(n=6),traumatic brain injury group(TBI,n=6),fracture group(n=36),and fracture group combined with traumatic brain injury(TBI+F,n=36).
    方法:实验于2003-10/2005-02在河北医科大学生化实验室完成。 选择清洁级成年雄性SD大鼠84只,随机数字表法分为4组:正常对照组6只,脑损伤组6只,骨折组36只,脑损伤+骨折组36只。
    The fracture group:The tibia 1 cm below the tibial tubercle was traversed after exposed one side of tibia,and Kirschner wire of 1 mm in diameter was used for intrmedullary fixation.
    骨折组充分显露一侧胫骨后,在胫骨结节下1cm处横断胫骨,以直径1mm的克氏针作髓内固定。
    One week after operation,the TGF-β1 concentration in the fracture group was higher than the normal control group [(11.70±4.56),(4.42±2.10)μg/L,P < 0.05],and fell to normal level at the 5th week.
    骨折组术后1周血清转化生长因子β1含量高于正常对照组[分别为(11.70±4.56),(4.42±2.10)μg/L,P<0.05],第5周降至正常。
    The results showed that: ①The bone mineral density of the brain injury and ulnar fracture group at 6 weeks after injury was obviously higher than the only fracture group (t=2.11, P < 0.05);
    结果显示:①致伤后6周脑损伤合并尺骨骨折组家兔的患肢骨折愈合处骨密度显著高于单纯尺骨骨折组(t=2.11,P<0.05);
    and callus diameter of the brain injury and ulnar fracture group was greater than that of the only fracture group on both orthotopic and lateral position (t=2.10, 2.23, P < 0.05-0.01);
    脑损伤合并尺骨骨折组正、侧位X射线平片骨痂直径显著大于单纯尺骨骨折组(t=2.10,2.23,P<0.05~0.01)。
    ②The ultimate bending strength of the combined group was higher than the only fracture group [(161.674±10.060), (135.400±12.540) MPa, (t =2.05, P < 0.01)].
    ②致伤后6周脑损伤合并尺骨骨折组家兔患肢抗弯强度极限值显著高于单纯尺骨骨折组[(161.674±10.060),(135.400±12.540)MPa(t=2.05,P<0.01)]。
    Results Height,body weight and BMD of L2-4 and each site of proximal femur in vertebral fracture group were significantly lower than those in the control group(all P<0.01).
    结果脊椎压缩性骨折组身高、体重、腰椎2~4和股骨近端各部位BMD值均显著低于对照组(均P<0.01)。
    As to BMD of femoral neck or total hip in the fracture group,osteoporosis was diagnosed in 50.8% and 50.4% respectively.
    按股骨颈和全髋部BMD值,骨折组骨质疏松检出率各为50.8%和50.4%;
    [Result]Assessed the effect by Maryland foot score,the base line included every foot. Total excellent and good rate in operative group was 93%,it was 100% in type I fracture group,96% in type Ⅱ fracture group,75% in type Ⅲ fracture group.
    [结果]按M aryland足部评分系统评价,并以每足为基数,手术治疗组:优良率93%,其中Ⅰ型骨折优良率为100%,Ⅱ型骨折优良率为96%,Ⅲ型骨折优良率为75%。
    The result of nonoperative treatment group was:total excellent and good rate was 67%,it was 92% in type I fracture group,77% in type Ⅱ fracture group,there was not excellent and good patients in type Ⅲ fracture group.
    非手术治疗组:优良率67%,其中Ⅰ型骨折优良率为92%,Ⅱ型骨折优良率为77%,Ⅲ型骨折无优良患者。
    Results: Bone union came into being 4 weeks after operation in the gunshot fracture group, while 3 weeks in the control group.
    结果:兔股骨火器性骨折术后4周达到骨性愈合,而普通骨折术后3周达到骨性愈合。
    stress and strain had the outstanding changes in distal ones except the normal and stable fracture groups (p<0.05);
    远端锁钉间应变除正常股骨及稳定型骨折外均存在显著性差异(p<0.05);
    Methods: Sixty mature male SD(Sprangue-Dawley) rats having a mean body weight of 0.41kg were fed on an ordinary laboratory diet and were randomly divided into stabilized and non-stabilized fracture groups. Closed unstable transverse mid-diaphyseal fractures of the right tibia were created in three-point bending in the anesthetized SD rats given an intraperitoneal injection(2ml/kg body weight) of 2.5%thiopental sodium.
    方法 60只成年雄性SD大鼠,平均体重0.41kg,随机分为固定组和非固定组,每组30只,用质量分数2.5%硫贲妥钠(2ml/kg体重)腹腔内注射麻醉,采用三点弯曲方法造成右胫骨中段闭合性骨折模型。
    But the former's peak concentration maintained a longer time than the latter's did. IL-8 levels in serum of SCI groups were higher than the one of limbs fracture group and normal control group ateach time point.
    SCI后血清中IL-6水平于伤后12h即有升高,然后逐渐下降,至伤后72h仍高于对照,SCI完全损伤组最大浓度与不完全损伤组无明显差异,但维持时间长于后者;
    There were no difference in TNF-a and IL-6 level postinjury between limbs fracture group and normal control group at each time point, and the former's IL-8 level only had a temporary increase.
    四肢骨折患者伤后各时间段TNF-α,IL-6水平与正常人无显著性差异,IL-8仅有一过性升高。
 

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