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暴发性肝炎
    Methods Some common hepatic diseases and digestive cancers were investigated,including 13 cases of autoimmune hepatic diseases, 19 cases of fulminant hepatitis,22 cases of viral chronic hepatitis, 25 cases of hepatic fibrosis or hepatic cirrhosis, 18 cases of hepatocarcinoma and 9 cases of gastric cancer.
    方法各种肝病患者包括自身免疫性肝病13例,急性暴发性肝炎19例,慢性病毒性肝炎22例,肝纤维化或肝硬化25例,肝癌18例,胃癌9例。
    TRANSGENIC RESCUE FROM FULMINANT HEPATITIS IN LEC RAT BY INTRODUCING HUMAN ATP7B cDNA
    人ATP7B基因对Wilson病动物模型LEC大鼠暴发性肝炎的治疗
    These data showed that the LEC rats were successfully rescued from fulminant hepatitis after introducing of human ATP7B gene.
    说明人ATP7B的导入 ,成功地抑制了Wilson病动物模型LEC大鼠的暴发性肝炎的发生。
    Preliminary Research on the Therapeutic efficacy of Bifidobiogen complex for Cyprinus carpio with fulminant hepatitis.
    复方回春生对鲤暴发性肝炎治疗效果的初步研究报告
    Relevance of Hepatitis B Variants for the Development of fulminant Hepatitis
    乙型肝炎病毒变异与暴发性肝炎
    Possible association of vigorous hepatitis B virus replication with the development of fulminant hepatitis
    乙型肝炎病毒的高复制水平与暴发性肝炎发生的可能相关性
    In 1992, Tiegs G et al. found Con A i.v. injection would induce a T cell-dependent fulminant hepatitis in mice.
    1992年,Tiegs G等人发现通过尾静脉注射ConA,可以诱导小鼠产生暴发性肝炎并造成严重的肝脏损伤。
    Methods From Jan 2001 to Feb 2002, 11cases of LDLTs were performed in our department. Of all 11 LDLTs, the cases of liver cirrhosis were Wilson's disease in 10 patients and fulminant hepatitis with liver function failure in 1 patient.
    方法  2 0 0 1年 1月至 2 0 0 2年 2月 ,我院行活体肝移植 1 1例 ,其中 Wilson’s病 1 0例 ,暴发性肝炎、肝功能衰竭 1例。
    Results The level of IL-17 was significantly higher in the hepatic disease groups than that in the normal control(P<0.01). The level of IL-18 was markedly higher in the autoimmune hepatic disease groups and fulminant hepatitis. However, the level of IL-18 in viral chronic hepatitis,hepatic fibrosis and cancer groups was significantly lower than that of the healthy control(P<0.05).
    结果106例肝病患者及胃癌患者血清中IL-17的水平较正常对照组均有升高(P<0.01),IL-18水平除了在自身免疫性肝病和急性暴发性肝炎中有升高外,而在慢性病毒性肝炎、肝纤维化、肝癌和胃癌中较正常对照均有不同程度的降低(P<0.05)。
    Conclusion The level of IL-17 is positively associated with the degrees of chronic hepatic diseases. Except for autoimmune hepatic diseases and fulminant hepatitis,the level of IL-18 is significantly low in viral chronic hepatitis,hepatic fibrosis and cancer. The causes and its significance remain to be clarified.
    结论慢性肝病患者血清中IL-17水平与疾病的严重程度呈正相关,IL-18除在自身免疫性肝病和急性暴发性肝炎中有升高外,在慢性病毒性肝炎、肝纤维化、肝癌及胃癌中均有明显的降低,其原因和意义有待于阐明。
 

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