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造血重建
    Methods:Half matched BMT was performed in C 57 BL 6 murine model of acute radiation disease to observe the survival rate,hematopoietic recovery,GVHD and GVL in the mice,controlled with unmatched allogeneic BMT group.
    方法 :以 C57BL - 6小鼠急性放射病为模型 ,进行半相合小鼠骨髓移植 ,同时设异基因骨髓移植为对照 ,观察移植后小鼠存活率、造血重建、GVHD或 GVL作用。
    Conclusion Both MNC count and CD 34 + cell count can reliably predict hematopoietic recovery after APBSCT.
    结论 MNC计数和CD3 4 + 细胞计数均能可靠预测自体外周血干细胞移植后的造血重建
    he methods of mobilization and collection of stem cells in peripheral blood stem cells transplantation(PBSCT)and the association between the number of stem cells transplanted and hematopoietic recovery were studied.
    对22例自体外周血干细胞移植(APBSCT)的三种动员方案、采集方法及移植的外周血干细胞(PBSC)数量与造血重建关系,进行了研究。
    Investigation was carried out on the effects of stem cell factor (SCF) in combination with interleukin 3(IL 3) on expansion of mice 5FU treated 3 days′ bone marrow cells(d3 5FU BMC )in vitro using the method of colony culture and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells .
    采用集落培养的方法研究了干细胞因子( S C F) 联合白介素3( I L3) 对小鼠5氟尿嘧啶(5 F U ) 处理3 d 的骨髓细胞(d35 F U B M C) 的体外扩增作用及其对致死量照射小鼠造血重建功能的影响。
    TPO can stimulate hematopoietic recovery after radiation injury.
    TPO可促进辐射损伤后的造血重建 ,有可能解决急性放射病中血小板恢复滞后的问题。
    Methods Hematopoietic recovery (peripheral blood cell counts, bone marrow aspirates, bone marrow biopsy, in vitro culture of hematopoietic progenitors), immunity of T lymphocyte, quality of life and side effects of the therapy were assessed in 50 SAA patients who have survived more than 3 years after IST.
    方法 对 50例IST后存活 3年以上SAA患者长期随访 ,了解其造血重建 (血常规、骨髓象、骨髓活检、造血祖细胞体外培养 )、T淋巴细胞免疫、生活质量及治疗不良反应等情况。
    Result:①Hematopoietic recovery was significantly quicker after APBSCT than that after purged or unpurged ABMT.
    结果 :①APBSCT组造血重建较其他两组显著加快 ;
    Objective: To investigate hematopoietic recovery, graft-versus-host disease (GVHD) and other complications related to umbilical cord blood transplantation (UCBT).
    目的 :研究脐血移植 (CBT)在恶性血液病长期造血重建和移植物抗宿主病 (GVHD)及其他移植相关并发症发生情况。
    All patients achieved hematopoietic recovery after transplantation.
    所有患者移植后均获得造血重建
    Half-matched murine bone marrow and spleen cells mixed with certain percent of syngeneic spleen cells were activated in vitro with IL-2 and underwent mixed half-matched BMT to observe their death rate, hematopoietic recovery of myelocytic lineage, spleen node count, mixed lymphocyte reaction in vivo, chimerism and pathological changes, to compared with GVHD reactions of various transplant models.
    半相合鼠骨髓和脾细胞中混合一定比例的同基因脾细胞,经白细胞介素-2体外活化后,进行活化半相合混合骨髓移植。 观察移植后小鼠死亡率、白细胞系造血重建、脾结节、体内混合淋巴细胞培养、嵌合体及病理学改变,比较不同移植方式的GVHD反应。
    Results Among 121 cases,116 cases had been persistently engrafted. Three cases suf- fered from graft rejection and 2 cases died of infectious complications before hematopoietic recovery.
    结果121例患者中,116例患者获得造血重建,3例移植失败,2例在移植物植活前因严重感染死亡。
    Conclusion Compared with classical myeloablative stem cell trans-plantation in SLE, NAST has a rapid hematopoietic recovery, slighter suppression of peripheral blood, lower in-fectious rate. NAST is safe and effective in treating SLE.
    结论与经典的清髓性HSCT治疗SLE比较,NAST造血重建快,外周血象受抑程度低,治疗安全、有效。
 

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