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肝炎患者
    Relation between Serum Trace Elements and Products of Lipid Peroxidation in Patients with Hepatitis B:A Clinical Epidemiological Study
    乙型肝炎患者血清微量元素与脂质过氧化产物相关性的临床流行病学研究
    Thirty-one pathents(M21.F10;age 33 ± s 6 a) with chronic hepatitis B were treated with aciclovir 750 mg in Ringer's solution 500 mL iv,gtt. qd for 1 mo.
    静脉滴注阿昔洛韦治疗慢性乙型肝炎患者31例(男性21例,女性10例;年龄33±s6a),750mg,qd,共1mo。
    Methods Contents of serum HBV DNA and LN,HA,PⅢ,Ⅳ C in 30 patients with chronic active hepatitis B before treatment and 3,6,9 months after Lamivudine treatment were determined by PCR? Flourescence quantity and competitive radioimmunoassay respectively.
    方法 对 30例慢性活动性乙型肝炎患者治疗前和拉米夫定治疗 3、6、9个月后的血清 ,分别采用荧光全定量PCR法测定HBVDNA浓度和竞争性放射免疫法测定层粘连蛋白(LN)、透明质酸 (HA)、Ⅲ型前胶原 (PⅢ )、Ⅳ型胶原 (ⅣC)水平并进行比较。
    Pharmacokinetics of omeprazole in patients with chronic hepatitis B
    奥美拉唑在慢性乙型肝炎患者中的药动学
    Results showed that 17 types of amino acids were significantly increased in acute hepatitis and 13 in fulminant hepatic failure, and the BCAA/AAA molar ratio was significantly decreased in both groups of patients.
    结果表明:急性肝炎患者17种氨基酸、重症肝炎患者13种氨基酸有显著增多;
    The mechanism and clinical significance of metabolic disturbances of amino acids in patients with acute hepatitis are discussed.
    讨论了肝炎患者血浆氨基酸代谢紊乱的机理和氨基酸测定的临床意义。
    Among these, the HSS from human fetal liver had the highest activity and that from neonatal pig liver had the lowest activity. 50 cases of severe hepatitis and 100 cases of chronic active hepatitis were treated with HSSs. The results showed that HSS has a definite therapeutic effect in lowering death rate of severe hepatitis and improving hepatocyte function of chronic active hepatitis.
    临床应用乳猪肝和乳牛肝HSS治疗重型肝炎50例、慢性活动性肝炎100例,结果表明HSS在降低重型肝炎的死亡率和改善慢性肝炎患者肝功能方面均有很确切的疗效,其中乳牛肝HSS的疗效又优于乳猪肝HSS。
    In order to study the affection of neutralizing antibody on the therapeutic effect of IFNα -2b,NBA was used to detect the neutralizing antibody to against IFN in the sera from 27 patients with chronic hepatitis B.The results indicated that neutralizing antibody against IFN was present in 15 of 27 patients who had been treated with IFNα-2b,and the overall frequency of neutralizing antibody was 55.6%(15/27).
    为了解干扰素治疗后干扰素中和抗体的产生及对干扰素疗效的影响,用中和生物法检测了27例乙型肝炎患者干扰素治疗前后血中干扰索中和抗体。 27例患者接受干扰素治疗后,15例血中检出中和抗体(55.6%;15/27)。
    AIM and METHOD:The effects of alcohol on lipopolysaccharide (LPS) eliminating actions of liver Kupffer cells in rats with chronic alcohol-induced liver injury and in patients with severe acute alcoholic hepatitis were observed.
    目的和方法:应用免疫荧光及免疫电镜技术,对慢性酒精投与之实验大鼠及重症酒精性肝炎患者肝脏枯否细胞对LPS的清除功能进行了观察。
    FITC fluorescent intensity in Kupffer cells in the liver samples of patients with acute severe alcoholic hepatitis was significantly lower than of normal controls.
    重症酒精性肝炎患者肝穿组织枯否细胞内抗LPS荧光显色亦显著低于正常对照。
    The subjects of in vivo study were patients with chronic hepatitis B. Results Compound 861 could significantly inhibit HSC proliferation and increase the apoptosis rate of HSC dose-dependently and time-dependently compared with the control group.
    临床研究对象是慢性乙型肝炎患者。 结果复方861显著抑制体外培养的HSC增殖,随着药物剂量的增加和时间的延长,HSC的凋亡明显增多,凋亡率增加,呈剂量和时间依赖。
    The clinical study elucidated that the HSC was activated and proliferated in patients with chronic hepatitis B. After compound 861 treatment for 6 months, the number of activated HSC decreased and the apoptosis of HSC could be seen in the liver biopsy.
    在慢性乙型肝炎患者中,肝星状细胞大量活化增生。 复方861治疗6个月后,活化的星状细胞数量显著减少,可观察到其凋亡。
    Methods:Forty patients with chronic HBV hepatitis were divided evenly into 4 groups.
    方法:将40例慢性乙型肝炎患者分为4组(A~D),每组10例。
    RESULTS:The plasma concentration versus time curve following intravenous 40mg OME in patients with chronic hepatitis B was conicident with two-compartment model,and the elimination half-life was (3.02±0.24)h,which was longer than the value in the healthy volunteers. The peak concentration and CLS in patients with chronic hepatitis B was higher and CLS was lower than the values in the healthy volunteer.
    结果:慢性乙型肝炎患者静滴OME的血药浓度曲线符合二室模型,消除半衰期为(3.02±0.24)h,明显长于国内外文献报道的健康人结果,药物清除明显减退,峰浓度明显高于健康人。
    CONCLUSIONS:The dosage of OME may be given in the half of a routine dosage or adjusted conditionally for patients with chronic hepatitis B.
    结论:慢性乙型肝炎患者应用OME时给药剂量可减半或酌情调整。
    Methods A cohort of 30 female patients of hepatitis with unknown causes was studied through clinical observation, serum test for autoantibodies and markers of viruses associated with hepatitis and routine liver function examination.
    方法 对 30例病因不明的女性肝炎患者 ,进行各种血清肝炎相关病毒标志、自身抗体、肝功能检测及临床分析 ,并对 1 0例患者进行常规病理检查。
    Methods 62 patients with chronic hepatitis B treated by CD3AK cell autotransfusion were divided into two groups. 15 patients treated by CD3AK cell autotransfusion and interleukin-b vein autotransfusion mixedly were mixed autotransfusion group, and 47 patients treated by CD3AK cell autotransfusion and interleukin-b vein autotransfusion respectively were respective autotransfusion group. The autotransfusion reaction of two groups were observed.
    方法将62例接受CD3AK细胞输入治疗的慢性乙型肝炎患者分为两组:用CD3AK细胞输入与白介素-2混合静脉输入的15例患者为混合输入组,采用CD3AK细胞、白介素-2分别单独静脉输入的47例患者为分开输入组,观察两组输入反应情况。
    Objectives To evaluate the efficacy and safety of h um an hepatocyte transplantation in the treatment of severe hepatitis induced by dr ugs.
    目的探讨人肝细胞体内移植治疗药物性重型肝炎患者的有效性与安全性。
    Methods 65 patients sufferred from drug-induced hepatitis were randomly assigned into two groups.
    方法将65例药物性肝炎患者随机分为2组。
    The meta-analysis results of the efficacy and safety of ribavirin were reviewed. In comparing to interferon mono-therapy,the combined therapy of interferon and ribavirin had higher efficacy and higher incidence of adverse reactions in treatment of chronic hepatitis C.
    本文对利巴韦林有效性和安全性的meta分析进行了综述,在丙型肝炎患者中,与干扰素单独治疗相比,利巴韦林/干扰素联合治疗对丙型肝炎有更好的疗效,但增加了不良反应的发生率。
 

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