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混合型高脂血症
    Conclusion Acipimox combined with Fluvastatin can significantly lower TC,LDL-C,TG and raise HDL-C in patients with mixed hyperlipemia,the adverse reaction of Acipimox and Fluvastatin are mild and can be well tolerated.
    3组患者TC、LDL-C和TG分别下降31%、37%和40%,HDL-C升高,联合用药组降低TC、LDL-C、TG,升高HDL-C的疗效优于单药治疗。 结论阿昔莫司和氟伐他汀联用可全面调节血脂,有效治疗混合型高脂血症
    Effect of Atorvastatin on Endothelium-Dependent Diastolic Function of Patients with Mixed Hyperlipemia
    阿托伐他汀对混合型高脂血症患者血管内皮依赖性舒张功能的影响
    Curative Effects and Safety Study of Acipimox Combined with Fluvastatin Treating the Aged with Mixed Hyperlipemia
    阿昔莫司联合氟伐他汀治疗老年混合型高脂血症的疗效和安全性研究
    Objective To observe the effect of short term treatment with atorvastatin on brachial endothelium dependent diastolic function of patients with mixed hyperlipemia.
    目的 观察阿托伐他汀对混合型高脂血症患者血管内皮依赖性舒张功能的影响。
    Method 60 patients with mixed hyperlipemia were treated with atorvastatin(10mg/d;po) for 8 weeks. 60 healthy adults were as control group. Blood lipids were measured,and the baseline of brachial angiobore,blood flow and the changes of these at response to nitroglycerin and reactive hyperemia were measured by Dopple ultrasound before and after treatment.
    方法  60例混合型高脂血症患者进行 8周阿托伐他汀片 10mg/d ,口服治疗 ,60例健康人群为对照组 ,治疗前后测定血脂以及用超声多普勒测定肱动脉血管内径、血流量以及反应性充血和含服硝酸甘油片后肱动脉内径和血流量变化。
    Conclusions Alorvastatin has obvious effect on the patients with mixed hyperlipemia,and it can obviously improved the brachial artery vascular endothelium dependent diastolic function. This role may due to direct effect on endothelium cells,but not related to lipid lowering action.
    结论 阿托伐他汀治疗混合型高脂血症疗效明显 ,并显著改善肱动脉内皮依赖性舒张功能 ,这一作用源于其对内皮细胞的直接作用 ,可能独立于降脂作用之外
    Methods 90 cases with mixed hyperlipemia were divided into three groups at random. Acipimox 250mg bid was given to 30 cases in group A,Fluvastatin 40mg qd was given to 30 cases in group B,Acipimox 250mg bid and Fluvastatin 40mg qd were given to 30 cases in group C.
    方法将90例(男84例,女6例)混合型高脂血症患者随机分为3组,阿昔莫司组患者每天早晚各服1次阿昔莫司,250mg/次; 氟伐他汀组患者每晚服氟伐他汀40mg;
 

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