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    [Objective] In order to research on the effection of moderate hypothermia on cerebrospinal fluid tumor necrosis factor a (TNFa),interleukin-6(IL-6)and interleukin-8(IL-8) levels and therapy mechanism after severe traumatic brain injury in humans.
    [目的]研究亚低温治疗对重型颅脑创伤患者脑脊液中TNF_α、IL-6及IL-8水平的影响,并探讨亚低温治疗的机理。
    (3) The content of TNFa,IL-6 and IL-8 began to decrease from 12 to 24 hour after moderate hypothermia therapy.
    (3)亚低温治疗后12一24小时,下NF。 、IL一6和!
    Objective:To evaluate the effect of retrograde coronary sinus perfusion in beating heart surgery in alleviating the systemic inflammatory induced by CPB on detecting tumor necrosis factor-α(TNF-α), interluekin-6(IL-6), interluekin-8 (IL-8), interluekin-10(IL-10), polymomhoneuclear(PMN) during surgery of retrograde coronary sinus perfusion in beating heart and operation on arrested heart with moderate hypothermia CPB and after.
    目的:通过测定逆行灌注心脏不停跳手术和传统中低温心脏停跳手术中和术后中性粒细胞(PMN)、细胞因子如肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、白介素-10(IL-10)水平高低来评价逆行灌注心脏不停跳手术对减轻体外循环炎性反应的作用。
    Objective: To observe the changes of S-100B、 NSE protein level and their influences to cerebral oxygen metabolism at different phase point of various anesthetic methods cardiopulmonary bypass (CPB) coronary artery bypass graft(CABG) with moderate hypothermia. To evaluate the relationship between S-100B、 NSE, indexes of cerebral oxygen metabolism and postoperative cerebral injury, mental function.
    目的:观察不同麻醉方法下中低温体外循环(CPB)冠状动脉搭桥术(CABG)中各时点颈内静脉血S-100B、NSE蛋白水平表达,以及对脑氧代谢指标的影响,评价S-100B、NSE及脑氧代谢指标与术后脑损伤和精神神经功能改变的相关性。
    Objective The aim of this study was to reproduce an asphyxiant cerebral anoxia model with Wistar rats and to investigate the neuroprotective effects of moderate hypothermia and ketamine during a simulative procedure of circulatory collapse in clinical anesthesia.
    目的:应用Wistar大鼠窒息性脑缺氧复苏模型,探讨氯胺酮与亚低温技术在模拟临床麻醉过程中发生循环停止条件下,对脑缺血/缺氧的脑保护作用机制及其相互关系,为临床脑复苏与脑保护工作提供理论依据。
    Methods Thirty-eight healthy Newzealand rabbits were randomly divided into five groups: normal control group(group Ⅰ ,n=6), normal temperature group(group Ⅱ ,n=8), mild hypothermia group(groupⅢ,n=8), moderate hypothermia group(groupⅣ,n=8), regional hypothermia group(groupⅤ,n=8).
    方法:新西兰大白兔38只,随机分为正常对照组(Ⅰ组,n=6只)、常温组(Ⅱ组,n=8只)、浅低体温组(Ⅲ组,n=8只)、中低体温组(Ⅳ组,n=8只)、创伤局部降温组(Ⅴ组,n=8只)。
    Objective To elucidate the clinical significance of pituitary endocrine such as thyroid-stimulating hormone(TSH) 、 triiodothyronine (T_3) 、 thyrexine (T_4) 、 adrenocorticotropic hormone (ACTH) changes after moderate hypothermia treatment for acute severe diffuse axonal injury.
    目的 研究重度弥漫性轴索伤(DAI)后垂体内分泌激素:促甲状腺素(TSH)、三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、促肾上腺皮质激素(ACTH)变化的临床意义,并进一步采用亚低温治疗来观察上述激素的变化,比较亚低温组与常温组治疗上的优劣,为临床治疗提供客观理论依据。
    Results After acute severe diffuse axonal injury, The serum TSH、 T3、 T4 in normal temperature group and moderate hypothermia group all decreased compared to the normal group(P<0.01),But the serum TSH、 T3、 T4 in normal temperature group decreased significantly than that in moderate hypothermia group (P<0.01).
    结果 弥漫性轴索伤后,常温组和亚低温组TSH、T_3、T_4均下降,与对照组比较有显著性差异(P<0.01),但常温组TSH、T_3、T_4较亚低温组下降更明显(P<0.01)。
    The serum ACTH in normal temperature group and moderate hypothermia group all increased compared to that in the normal group (P<0.01),The serum ACTH in normal temperature increased significantly than that in moderate hypothermia group (P<0.01).
    常温组和亚低温ACTH均升高,与对照组比较有显著性差异(P<0.01),但常温组ACTH较亚低温组升高更明显,有统计学意义(P<0.01)。
    Experiment methods Thirty-two New zealand rabbits were randomly divided into four groups: control group(groupⅠ,n=8), normal temperature group(groupⅡ,n=8), mild hypothermia group(groupⅢ,n=8), moderate hypothermia group(groupⅣ,n=8).
    方法:新西兰大白兔32只,随机分为正常对照组(Ⅰ组,n=8)、常温组(Ⅱ组,n=8)、浅低体温组(Ⅲ组,n=8)、中低体温组(Ⅳ组,n=8)。
    Objective To evaluate the difference of mitral valve replacement under Beating heart and mitral valve replacement(MVR) arrested heart with moderate hypothermia by detecting the expression of heat shock protein 70(HSP70) in the myocardial tissue and level of antibody against HSP70 in serum of MVR patients.
    目的:通过分别检测不停跳下心脏二尖瓣置换术和停跳下二尖瓣置换术患者心房组织及血清热休克蛋白70(HSP70)的表达差异,探讨浅低温不停跳下心脏二尖瓣置换术和中低温停跳下二尖瓣置换术的在心肌保护上的差异。
    The first group, 9 patients, underwent profound hypothermia (nasopharyngeal temperature 18-22℃) and second group with moderate hypothermia (nasopharyngeal temperature 28-32℃).
    深低温体外循环组,鼻咽腔温度18~22℃,n=9。 中度低温体外循环组,鼻咽腔温度28~32℃,n=9。
    Results: Compared with the control and ischemic group, mild to moderate hypothermia could reduce brain water content (P<0.05) and malonaldehyde content (P<0.01), while increase the activity of Na + K + ATPase (P<0.01).
    结果:与对照组和缺血组相比,亚低温组能阻止Na+-K+-ATP酶活性的降低(P<0.01)、降低脑组织含水量(P<0.05)和MDA含量(P<0.01)。
    The heart automation revival rate in moderate hypothermia group was higher than that in deep hypothermia group (66.3% vs 48.7%,P<0.05).
    中度低温组心脏自动复跳率为66.3%,明显高于深低温组(48.7%)(P<0.05)。
    Of them, 36 cases were operated on ASD、VSD repair and partial anomalous pulmonary venous drainage under non-cooling concomitant circulation, 4cases with mitral and aorta valve replacement under warm oxygenated blood continuousmyocardial perfusion under cardiopulmonary bypass with TOF correction treatment under deep hypothermia circulation arrest and 184 cases with other kinds of operations under moderate hypothermia cardiopulmonary bypass.
    不降温并行循环行房室技修补及部分型肺静脉异位引流矫治36例,体外循环温氧合血心停搏液持续心肌灌注行二尖瓣及主动脉瓣替换4例,深低温停循环行TOF根治术2例,中低温作外循环下行其他各类型手术184例。
    selective brain cooling, especially moderate hypothermia (28 32 degrees centigrade), provides better cerebral protection by means of inhibiting the expression of ICAM 1mRNA and the infiltrations of PMNL and M Φ in brain
    结论 I/R损伤可诱导ICAM 1mRNA表达和PMNL、MΦ浸润 ; 头部重点低温 ,特别是中度低温 (2 8℃~ 32℃ )能显著抑制ICAM 1mRNA表达 ,减轻PMNL和MΦ在脑的浸润 ,产生更好的脑保护作用。
    Results:①The blood SOD levels of moderate hypothermia group were much higher than those of the normothermia group at the first and third days after brain injury( P <0.01);
    结果 :①亚低温组伤后第 3d、7d中静脉血SOD含量比常温组有明显升高 (P <0 .0 1 ) ;
    ②Acccording to GOS,prognoses of the moderate hypothermia group were more favourable than those of the normothermia group( P <0.01).
    ②出院时GOS评估 ,亚低温组预后明显优于常温组 (P <0 .0 1 )。
    Moderate hypothermia was used in patients with severe brain contusion. Results According to Glasgow Outcome Scale (GOS) , good in 80 (57 97% ) , moderate disablement in 27 (19. 56% ) , severe disablement in 12 (8. 7% ) and death in 19 (13. 77% ).
    结果 按GOS评价,恢复良好80例(57.97%),中残27例(19.56%),重残12例(8.7%),死亡19例(13.77%)。
    Results The ET, MDA and LPO levels of serum and hemotoma in patients with moderate hypothermia were significanthy lower than that of No moderate hypothermia ( P < 0.01 ), the SOD and NOS level in serum in patients were significantly higher than that of No moderate hypothemia respectively( P < 0.01 , P < 0.05 ).
    结果 亚低温治疗后血浆和脑血肿引物ET、MDA及LPO含量均较对照组及治疗前低 (P <0 .0 1) ,而血浆和脑血肿引流物SOD及NOS含量分别较对照组及治疗前高 (P <0 .0 1,P <0 .0 5 )。
 

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