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    PD-L and PD-1 interaction involves in maintenance of peripheral tolerance.
    PD-1也参与了一系列疾病的发病。
    Objective CD4~+CD25~ high regulatory T cells (Treg) have been shown to play an important role in maintaining peripheral tolerance against self and foreign antigens, and in suppressing T cell immune response.
    目的观察不同类型HBV感染患者外周血CD4+CD25high调节性T细胞(Treg)的频率和临床指标的相关性。
    Recently, dendritic cells (DCs) are found to play a dual role in the immunological system. Apart from inducing immune response as antigen presenting cells (APCs), DCs can also induce central and peripheral tolerance.
    近年来,树突状细胞(dendritic cells,DCs)被发现在免疫系统中扮演着双重角色,除作为抗原提呈细胞(antigen presenting cells,APC)诱发免疫反应外,还能诱导中枢或周围性免疫耐受。
    Peripheral tolerance also involves in the deletion of autoreactive T cells, which includes all the other means, such as DCs and regulatory T cells.
    因此,机体的免疫系统还会通过其它方式灭活及清除胸腺外的自身反应性T细胞,我们称之为外周耐受。
    Part2: Deficiency in both central and peripheral tolerance is essential for the development of MLDS-DM To further study the role of abnormal immunotolerance mechanism in the development of diabetes , the makeup and function of cells in thymus was observed and the frequency and function of CD4+CD25+Treg with immunoregulatory function in the spleen was detected. Ⅰ.
    说明模型鼠胸腺功能异常可能是导致自身反应T 细胞和CD4~+CD25~+Treg 的胸腺选择异常的原因。
    Objective: Recent researches showed that dendritic cells can either initiate T cell immunoreaction or promote peripheral tolerance depending on their state of maturaton. Tolerogenic dendritic cells(Tol-DC) have been defined by immature phenotype and the ability to inhibit T cell responses. RelB is a critical nuclear transcription factor NF- κB family member required for myeloid DC maturation.
    树突状细胞(dendritic cell,DC)具有激活免疫应答或诱导免疫耐受的功能,未成熟状态的树突状细胞倾向于诱导免疫耐受产生,被称为“致耐受DC(tolerogenic dendritic cell,Tol DC)”。
    Studies show that engagement of PD-l can downregulate the immune response of activated T,B cells, and its biological significance in sustaining peripheral tolerance.
    研究证实,增强PD-1的信号可以下调已活化的T、B细胞在外周组织中的应答,在维持外周T、B细胞耐受中发挥重要的作用。
    IL-2, through its pivotal role in activation-induced cell death (AICD), is involved in peripheral tolerance through the elimination of selfreactive T cells.
    近来在T细胞系上进行的一系列研究表明,作为FasL的主要表达细胞,T细胞上FasL的表达受到严格的制约,大多数情况下并不组成型表达在活化T细胞表面,而是以预存蛋白的形式蓄积在活化T细胞的胞浆当中.
    IFN-γand IL-4 reflect the level of Th1 and Th2, respectively, and, it is always to use the rate of IFN-γ/IL-4 to reflect the level of Th1 and Th2 in immunology. JRA is a systemic autoimmune disease that the homeostatic function of T cell is damaged. In JRA patients, the peripheral tolerance mechanism is confused, T cell proliferation function will be abnormal, the amount of potentiality autoreactivity T cells will be increased.
    结果:对照组及JRA 组IFN-γ、IL-4 分别为10.68±3.55pg/ml、18.84±3.92pg/ml、2.45±0.45pg/ml、1.86±0.54pg/ml。
 

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