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rb基因的
    Conclusion The result indicated the mutation or lack of RB gene was not the only reason in the tumorigenesis of LSCC, and protein RB might cooperate with cyclin D 1, P16, CDK4 to play a role in the process of tumorigenesis.
    结论 细胞调控周期中Cyclin D1、RB、P16、CDK4等因素在喉鳞癌的发生发展中可能起着协同作用,而并非主要由于RB基因的突变和缺失造成细胞癌变。
    [WT5”HZ]Methods [WT5”BZ]Based on establishing vitreous RB transplantation tumor in nude mouse,constructing retrovirus vector of Rb gene PBabe Rb and transfecing it into the RB transplantation model by liposome Dosper,the change of cell cycle of the RB transplantation tumor by flow cytometry(FCM)was analysed.
    方法 在建立裸鼠眼玻璃体腔 RB移植瘤模型及构建 Rb基因的逆转录病毒表达载体 PBabe- Rb的基础上 ,用脂质体 Dosper介导法将 Rb基因导入裸鼠 RB移植瘤 ,流式细胞仪检测 RB移植瘤细胞周期变化。
    With the anti-Rb polyclonal antibody,the expression of Rb gene in 15 cases of retinoblastoma were studied by Western Bloting. Using laser densitometry technique,we made a quantitative comparison of the expression dose of Rb gene product between Rb tumor and normal retinal tissues. The relative concentrations of p105Rb in 13 RB patients were remarkably lower than those of normals.
    利用抗Rb基因蛋白产物的多克隆抗体对15例视网膜母细胞瘤Rb基因表达水平进行Western印迹分析,并采用激光密度分析仪对结果进行进一步精确的定量分析,表明15例视网膜母细胞瘤中仅有两例的Rb基因蛋白表达量与正常视网膜相似,其余13例几乎没有Rb基因的表达产物。
    The results suggest that Rb gene activity is possibly decreased in most cases of RB.
    提示在大多数视网膜母细胞瘤中,Rb基因的蛋白质产物缺乏。
    The results implied that the alterations of the deletion or loss of activity of Rb gene with high frequency might be associated with the carcinogenesis of NPC.
    这种高频率的异常变化,提示Rb基因的缺失或失活,与鼻咽癌的发生有密切关系。
    Our results suggest that Rb gene and p53 gene are closely associated with the tumorigenesis of NPC.
    结果表明,在13例鼻咽癌组织中有11例鼻咽癌组织有Rb基因的缺失或明显减弱,提示p53基因突变及Rb基因的缺失而导致的基因失活与鼻咽癌的发生有密切关系。
    This investigation sought to address if there is any change of Rb gene in 8 nasopharyngeal carcinoma (NPC) cell lines and, if yes, to observe the differences among them.
    为观察8株鼻咽癌细胞株(CNE1、CNE2、HNE1、HNE2、HNE3、HONE1、SUNE1和HK1)Rb基因的结构和表达情况。
    PURPOSE:To investigate the status and detailed structure of Rb gene in primary tumors and somatic cells of patients with retinoblastoma. To identify the character,origin and transmission of oncogenic point mutations.
    目的:研究RB患者肿瘤及体细胞内Rb基因的存在状态、细微结构、Rb基因突变的特征、起源与传递。
    3) Three cell cloning strains named as MC2, MC3 and MC4 were isolated by single cell cloning technique from the SO-Rb50-775, and mutation of Rb gene were also screened exon-by-exon by using PCR-SSCP-HA in MC2-11, MC3-ll, MC4-11 and MC3-138.Results: The 3.5Kb, 2.9Kb and 1.0Kb bands were deleted in the DNA of SO-Rb50-327 tumor cells, showing the deletion of Rb gene in SO-Rb50 cell line.
    用PCR-SSCP-HA法对MC2、MC3及MC4第11代细胞和MC3第138代细胞的Rb基因的27个外显子逐个筛查。 结果:SO-Rb50细胞系第327代细胞DNA缺失3.5Kb、2.9Kb及1.0Kb的三条带,证明SO-Rb50细胞系瘤细胞Rb基因缺失。
    Conclusion: Non functional Rb protein produced by gene mutation was one cause in the development of laryngeal neoplasma, howerver, Rb gene mutation was not common in pathogenesis of human laryngeal neoplasma.
    结论 :Rb基因突变导致的喉癌细胞不能产生有功能的 Rb蛋白可能是喉癌发生的原因之一 ,但 Rb基因的突变并不是喉鳞癌的常发事件。
 

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