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rb基因
    Initial Study in the Association between Proliferation of Rb Gene and Tumorigenesis of Retinoblastoma
    Rb基因扩增与视网膜母细胞瘤发生的关系初步探讨
    A Study of the Rb Gene Deletions in Unilateral and Sporadic Retinoblastomas
    单眼散发性视网膜母细胞瘤Rb基因缺失的研究
    RB Gene and Tumor Suppression .
    RB基因与肿瘤抑制
    Study of Rb Gene Deletions in Bilateral Retinoblastomas
    双眼视网膜母细胞瘤Rb基因缺失研究
    THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
    视网膜母细胞瘤Rb基因表达
    THE STATUS OF Rb GENE IN NASOPHARYNGEAL CARCINOMA
    Rb基因在鼻咽癌中存在状态的研究
    Prediction of Retinoblastoma:Linkage Analysis of Families with Hereditary Retinoblastoma by Using Polymorphic Sites within the Rb Gene
    应用Rb基因内多态位点作家系连锁分析预测视网膜母细胞瘤
    The structure, function and mutation of Rb gene promoter in normal individuals and retinoblastoma patients
    正常人及视网膜母细胞瘤患者Rb基因启动子结构、功能和突变的研究
    Study on the Deletion of RB Gene and Its Relationship to Risk Factors in Chinese Female Breast Cancer
    乳腺癌中RB基因缺失及与乳腺癌发病危险因素关系的研究
    Experimental research on apoptosis of retinoblastoma transplantation tumor induced by Rb gene
    Rb基因诱导视网膜母细胞瘤移植瘤细胞凋亡的实验研究
    he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T.
    RB基因位于13q14,全长150kb,编码一个由928个氨基酸组成的分子量为110000蛋白(pp110RB).它能特异性与SV40大T,E1A和E7结合.在视网膜细胞中,RB呈衡定组成性表达,其
    The status of Rb gene in nasopharyngeal carcinoma(NPC)and normal fetal nasopharynx tissues were studied by using biotin-14-dUTP labeled Rb cDNA 3.8kb probe in combination with streptavidin alkaline phosphatase luminescent detection system.
    首次应用生物素-14-dUTP标记Rb3.8kb探针,结合亲合素-碱性磷酸酶发光及自显影法,对Rb基因在鼻咽癌中存在状态进行了研究。
    therefore,the mutant gene is present in allsomatic cells. The segregations of four polymorphic sites within the Rb gene were analyzedin six farmilies with hereditary retinoblastoma. Two families were informed with probe p123M1.8,three were informed with probe p68RS2.0 and one was informed with PCR amplification of XbaI site;
    应用Rb基因内探针p68RS2.0,p123M1.8及PCR扩增Rb基因内多态位点Rbl.20及XbaI,对6个遗传性Rb家系进行连锁分析,结果6个家系均可获得信息。
    In order to observe the relation of tumor supperssor gene p53 and Rb gene to nasopharyngeal carcinoma, we investigated p53 gene mutations in exon 7 8 in 33 cases of nasopharygeal carcinoma (NPC), using single strand conformation ploymorphism analysis of PCR (PCR SSCP).
    为观察p53基因和Rb基因与鼻咽癌发生的关系,应用聚合酶链反应-单链构型多态分析技术(PCR-SSCP技术),检测33例鼻咽癌组织、4例鼻咽部炎性组织及3例正常鼻咽部组织中p53基因第7,8外显子的突变。
    RESULTS:Among 108 RB patients examined 80 cases were found to have subtle alterations affecting Rb locus,including 44 cases with homozygous Rb point mutations,20 cases with two independent heterozygous Rb point mutations,16 cases with heterozygous mutations involved in one allele of Rb gene.
    结果:108例RB肿瘤标本中80例(74%)存在Rb基因点突变,其中44例为纯合型,20例有二个独立发生的杂合型点突变,16例只检出一个杂合型点突变。
    Objective To investigate the DNA sequence of the 5′ untranslated region of the Rb gene in normal individuals and retinoblastoma patients and identify the elements involved in transcription regulation of Rb gene.
    目的检测正常人及视网膜母细胞瘤(RB)患者Rb基因5′端调控区的DNA序列,以及不同的DNA片段的转录调控活性,研究Rb基因启动子的结构、功能以及突变对功能的影响和与RB发病的关系。
    Conclusion The result indicated the mutation or lack of RB gene was not the only reason in the tumorigenesis of LSCC, and protein RB might cooperate with cyclin D 1, P16, CDK4 to play a role in the process of tumorigenesis.
    结论 细胞调控周期中Cyclin D1、RB、P16、CDK4等因素在喉鳞癌的发生发展中可能起着协同作用,而并非主要由于RB基因的突变和缺失造成细胞癌变。
    Objective [WT5”BZ]To investigate the effect of exogenous Rb gene on the cell cycle of vitreous retinoblastoma (RB) transplantation tumor in nude mouse.
    目的 观察外源性视网膜母细胞瘤基因 (Rb基因 )对视网膜母细胞瘤 (retinoblastoma,RB)移植瘤细胞周期的影响。
    [WT5”HZ]Methods [WT5”BZ]Based on establishing vitreous RB transplantation tumor in nude mouse,constructing retrovirus vector of Rb gene PBabe Rb and transfecing it into the RB transplantation model by liposome Dosper,the change of cell cycle of the RB transplantation tumor by flow cytometry(FCM)was analysed.
    方法 在建立裸鼠眼玻璃体腔 RB移植瘤模型及构建 Rb基因的逆转录病毒表达载体 PBabe- Rb的基础上 ,用脂质体 Dosper介导法将 Rb基因导入裸鼠 RB移植瘤 ,流式细胞仪检测 RB移植瘤细胞周期变化。
    2) A promoter and 27 exons of Rb gene were screened exon-by-exon by using PCR-SSCP at 415th and 713th passages of SO-Rb50 cell line.
    2.用PCR-SSCP法对SO-Rb50细胞系第415代及第713代瘤细胞的Rb基因27个外显子和1个启动子逐个筛查。 3.将SO-Rb50细胞系的第775代克隆出3个细胞株:MC2、MC3及MC4。
 

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