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rb基因的
    DETECTION OF LOSS OF HETEROZYGOSITY OF RB GENE BY VNTR POLYMORPHISM ANALYSIS IN HUMAN LEUKEMIA
    以VNTR多态性分析检测人类白血病RB基因的杂合子性缺失
    Analysis of Rb gene in primary acute lymphoid leukemia
    急性淋巴细胞白血病Rb基因的分析
    THE DETECTION OF RB GENE IN ORAL SQUAMOUS CELL CARCINOMA
    口腔鳞状细胞癌Rb基因的检测
    Expression and significance of p15 and Rb gene in human hepatocellular carcinoma tissue
    人肝细胞癌组织p15及Rb基因的表达意义
    EGFr and Rb gene amplification in fetal esophageal epithelium treated by alternariol
    经交链孢酚处理胎儿食管上皮组织中EGFr、Rb基因的扩增
    Over Expression of the Rb Gene in Human Colorectal Carcinomas and Adenomas and Its Significance in the Formation and Development of Tumor
    人类结肠癌、结肠腺瘤中Rb基因的过表达现象及其在肿瘤发生、发展中的意义
    2. The inversly correlation betweenp16 and Rb gene expression proved their negative feedback action.
    2.P16与Rb基因的蛋白表达呈显著的负相关关系,两者之间存在负反馈作用。
    Conclusions:(1) The results suggested P16 P53 Rb gene play important roles in occurance and development of BTCC,P16 gene major in deletion and P53 major in mutation.
    结论:①P16、P53、Rb基因的变化在膀胱癌发生发展中有重要作用,P16基因第2外显子以缺失为主,P53基因第5-8外显子以突变为主;
    Immunohistochemical method was used to detect the P16 and Rb gene expressions in 59 cases of transitional cell carcinoma (TCC) of bladder.
    应用免疫组织化学方法对59例膀胱移行细胞癌中P16及Rb基因的表达进行研究。
    The positive rate of P16 and Rb gene was 47.46%(28/59)and 71.19%(42/59) respectively. In only 18.64% (11/59),both P16 and Rb could be simultaneously detected. Lack of both the expressions in the same tumor tissue has not been observed.
    结果显示:59例中P16及Rb基因阳性表达率分别为4746%、7119%,其中11例肿瘤组织(1864%)P16及Rb基因均阳性表达,未发现同一肿瘤组织中同时存在P16及Rb基因的表达缺失。
    Purpose To study the relationship between the expressions of cyclinD 1 gene as well as Rb gene in breast carcinoma and the pathogenesis of the carcinoma.
    目的:探讨cyclinD1基因及Rb基因的表达与乳腺癌发生发展的关系。
    MethodsSP immunohistochemistry (IHC) was applied for the morphological observation-quality and localization detection and indirect immunofluorescence of flow cytometry (FCM) for the quantitative detection of the expression of Rb gene.
    方法用SP免疫组织化学(IHC)及流式细胞术(FCM)间接免疫荧光法对Rb基因的表达进行定性、形态学定位及定量检测。
    Conclusion There is a close correlation between the abnormal expressions of p16, Rb gene and the malignant transformation of hepatocyte.
    结论:p16和Rb基因的表达异常与肝细胞癌变关系密切。
    Methods The expression of P53,C erbB 2,Rb gene on the SGC 7901 gastric cell lines was detected by immunohistochemistry.
    方法 以 SGC-790 1胃癌细胞作为研究对象 ,采用免疫组化方法检测胃癌细胞中 P53、C- erb B- 2、Rb基因的表达情况。
    Conclusion The result indicated the mutation or lack of RB gene was not the only reason in the tumorigenesis of LSCC, and protein RB might cooperate with cyclin D 1, P16, CDK4 to play a role in the process of tumorigenesis.
    结论 细胞调控周期中Cyclin D1、RB、P16、CDK4等因素在喉鳞癌的发生发展中可能起着协同作用,而并非主要由于RB基因的突变和缺失造成细胞癌变。
    ②Negative relationship between the expression of Rb gene and the histological grades of oral SCC.
    ②Rb基因的表达与口腔癌组织学分级之间无明显关系。
    [WT5”HZ]Methods [WT5”BZ]Based on establishing vitreous RB transplantation tumor in nude mouse,constructing retrovirus vector of Rb gene PBabe Rb and transfecing it into the RB transplantation model by liposome Dosper,the change of cell cycle of the RB transplantation tumor by flow cytometry(FCM)was analysed.
    方法 在建立裸鼠眼玻璃体腔 RB移植瘤模型及构建 Rb基因的逆转录病毒表达载体 PBabe- Rb的基础上 ,用脂质体 Dosper介导法将 Rb基因导入裸鼠 RB移植瘤 ,流式细胞仪检测 RB移植瘤细胞周期变化。
    The mRNA expression of Rb gene and HSV-TK gene were detected by RT-PCR and Northern blot.
    应用RT-PCR和Northernblot检测TK和Rb基因的表达;
    mRNA expression of HSV-TK gene was demonstrated in OS732TK and OS732RbTK cells. Both exogenous and endogenous Rb gene expression could be detected in OS732Rb and OS732RbTK cells si-multa neously.
    并在mRNA水平检测到OS732TK和OS732RbTK细胞内HSV-TK基因的表达,在OS732Rb和OS732RbTK细胞内存在内源性和外源性Rb基因的表达;
    The U937 cells transfected with exogenous Rb gene via a recombinant adenovirus vector, however, showed that the expression levels of Rb gene within 12 h and 24 h incubation with Ox - LDL were significantly higher than that at 0 h ( P < 0.05), and the content of apoB within 12 h and 24 h incubation with Ox-LDL were significantly lower than that at 0 h ( P < 0.05 ) .
    而U937细胞在导人外源性Rh基因后,12 h、24 h细胞内的Rb基因 的表达显著高于对照组0 h(P<0.05); 细胞内载脂蛋白B含量则显著低于对照组0 h(P<0.05)。
 

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