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rb基因
    The Rb gene is localized to human chromosomel3ql4 and encode a 105kd protein.
    Rb基因位于人类染色体13q14,编码105Kd的蛋白质(pRb)。
    The Rb gene abnormality was one of the hereditary factors associated with the occurrence of lung cancer, and the abnormal Rb gene was found in 90% of small cell lung cancer (SCLC) and 10 -30% of non - small cell lung cancer ( NSCLC).
    在小细胞肺癌(SCLC)约90%,非小细胞肺癌(NSCLC)约10-30%存在Rb基因异常,Rb基因异常者因肺癌死亡的危险性比正常人高15倍,是肺癌发生的遗传因素之一。
    In recent years the new members of Rb gene family, p107 and Rb2/pl30 have been found, which are functionally similar to pRb but they are not entirely substitulive each other.
    近年来,又先后发现了Rb基因家族的新成员,包括p107,Rb2/p130。 p107和Rb2/p130功能上与pRb非常接近,但不完全相同。
    2. The inversly correlation betweenp16 and Rb gene expression proved their negative feedback action.
    2.P16与Rb基因的蛋白表达呈显著的负相关关系,两者之间存在负反馈作用。
    Conclusions:(1) The results suggested P16 P53 Rb gene play important roles in occurance and development of BTCC,P16 gene major in deletion and P53 major in mutation.
    结论:①P16、P53、Rb基因的变化在膀胱癌发生发展中有重要作用,P16基因第2外显子以缺失为主,P53基因第5-8外显子以突变为主;
    he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T.
    RB基因位于13q14,全长150kb,编码一个由928个氨基酸组成的分子量为110000蛋白(pp110RB).它能特异性与SV40大T,E1A和E7结合.在视网膜细胞中,RB呈衡定组成性表达,其
    The status of Rb gene in nasopharyngeal carcinoma(NPC)and normal fetal nasopharynx tissues were studied by using biotin-14-dUTP labeled Rb cDNA 3.8kb probe in combination with streptavidin alkaline phosphatase luminescent detection system.
    首次应用生物素-14-dUTP标记Rb3.8kb探针,结合亲合素-碱性磷酸酶发光及自显影法,对Rb基因在鼻咽癌中存在状态进行了研究。
    therefore,the mutant gene is present in allsomatic cells. The segregations of four polymorphic sites within the Rb gene were analyzedin six farmilies with hereditary retinoblastoma. Two families were informed with probe p123M1.8,three were informed with probe p68RS2.0 and one was informed with PCR amplification of XbaI site;
    应用Rb基因内探针p68RS2.0,p123M1.8及PCR扩增Rb基因内多态位点Rbl.20及XbaI,对6个遗传性Rb家系进行连锁分析,结果6个家系均可获得信息。
    In order to study the relationships between p53,Rb gene and Chinese os-teosarcoma,authers used labelled streptavidin-biotin method(LSAB)to detect the expressionof p. 53 and Rb protein in 30 human osteosarcomas,15 human normal bone and 15 human fetalbone tissues,respectively.
    为了研究p53、Rb基因和国人骨肉瘤的关系,作者应用LSAB免疫组织化学方法检测了30例人骨肉瘤、15例胎儿骨和15例正常骨组织中p53蛋白和Rb蛋白的表达情况。
    To detect the relation of p53 and Rb genes to the development of lung cancer,we used PCR and SSCP methods to analyse the mutations of p53 gene exons 5-8 and Rb gene exons 14-16,22-23 regions in 41 human lung cancer samples.
    为探讨肺癌发生的分子遗传学机理,采用聚合酶链反应及聚合酶链反应-单链构象多态性技术,对41例人肺癌组织中p53基因外显子5~8及Rb基因外显子14~16、22~23进行了突变分析。
    At same time we also analyzed the structural alteration of the Rb gene from 10 cases by Southern hybridization using the Rb cDNA. The deletion was found at 4. 5kb band in one case, at 9. 8kb and 7.5kb bands in another case.
    同时用Rb基因cDNA为探针Southern杂交检测了10例肝细胞癌,发现2例分别在4.5Kb和9.8Kb,7.5Kb处缺失。
    In order to observe the relation of tumor supperssor gene p53 and Rb gene to nasopharyngeal carcinoma, we investigated p53 gene mutations in exon 7 8 in 33 cases of nasopharygeal carcinoma (NPC), using single strand conformation ploymorphism analysis of PCR (PCR SSCP).
    为观察p53基因和Rb基因与鼻咽癌发生的关系,应用聚合酶链反应-单链构型多态分析技术(PCR-SSCP技术),检测33例鼻咽癌组织、4例鼻咽部炎性组织及3例正常鼻咽部组织中p53基因第7,8外显子的突变。
    Rb gene is one of the important modulating factors in cell proliferation and differentiation.
    Rb基因是细胞生长分化的重要调控因子。
    The results showed that the expression of Rb gene was present in 72. 94 % (62/85 ) of gastric cancer patients.
    本组胃癌Rb基因产物阳性表达为62/85(72.94%),与淋巴结转移呈极显著性正相关(P<0.01),与胃癌术后生存期呈极显著性负相关(P<0.01)。
    The positive rate of P16 and Rb gene was 47.46%(28/59)and 71.19%(42/59) respectively. In only 18.64% (11/59),both P16 and Rb could be simultaneously detected. Lack of both the expressions in the same tumor tissue has not been observed.
    结果显示:59例中P16及Rb基因阳性表达率分别为4746%、7119%,其中11例肿瘤组织(1864%)P16及Rb基因均阳性表达,未发现同一肿瘤组织中同时存在P16及Rb基因的表达缺失。
    RESULTS:Among 108 RB patients examined 80 cases were found to have subtle alterations affecting Rb locus,including 44 cases with homozygous Rb point mutations,20 cases with two independent heterozygous Rb point mutations,16 cases with heterozygous mutations involved in one allele of Rb gene.
    结果:108例RB肿瘤标本中80例(74%)存在Rb基因点突变,其中44例为纯合型,20例有二个独立发生的杂合型点突变,16例只检出一个杂合型点突变。
    Objective To investigate the DNA sequence of the 5′ untranslated region of the Rb gene in normal individuals and retinoblastoma patients and identify the elements involved in transcription regulation of Rb gene.
    目的检测正常人及视网膜母细胞瘤(RB)患者Rb基因5′端调控区的DNA序列,以及不同的DNA片段的转录调控活性,研究Rb基因启动子的结构、功能以及突变对功能的影响和与RB发病的关系。
    Results: The structural abnormal alterations of Rb gene were found in 7 cases of total samples, in which observed were the deletion of 54, 41 and 23Kb fragment in 6 cases. Rearrangement was detected in one case.
    结果在7/28例口腔鳞癌中发现Rb基因结构异常,其中6例出现5.4、4.1及2.3Kb片段缺失,1例出现6.2Kb新片段;
    There was an inverse relationshipbetween the expression of p16 and Rb gene protein (P < 0.05).
    p16和Rb基因蛋白的表达呈显著负相关(P<0.05)。
    Objective To investigate the expression condition of exogenous Rb gene in nude mouse vitreous transplantated retinoblastoma(RB) and its influence on the growth of the RB tumor in vivo.
    目的观察外源性Rb基因在视网膜母细胞瘤(retinoblastoma,RB)移植瘤内的表达情况,及其对RB移植瘤生长的影响,为进行RB体内基因治疗提供实验依据。
 

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