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rb基因
    Purpose To study the expression of p16 and Rb gene proteins in primary lung cancers.
    目的:研究p16和Rb基因蛋白的表达与肺癌临床病理学特征的关系。
    To study the effect of exogenous P 53 gene and Rb gene on migration of vascular smooth muscle cells(VSMC),a P 53 gene recombinant adenovirus vecter,AdCMV P 53 ,and a Rb gene recombinant adenovirus vector,AdCMV Rb,were transfected into the cultured VSMC derived from human umbilical artery.
    为研究外源性P53和Rb基因对血管平滑肌细胞迁移的影响,体外培养人脐动脉平滑肌细胞,将P53基因和Rb基因重组腺病毒载体转染平滑肌细胞72h后,检测平滑肌细胞的迁移。
    The migration of VSMC was tested after introduction of exogenous P 53 gene and Rb gene for 72 h. The results showed that migration distances of VSMC in control group were significantly longer than those of VSMC transfected with AdCMV P 53 and AdCMV Rb(P<0.05,P<0.001).
    结果显示,对照组平滑肌细胞的迁移距离为0.84±0.36cm(X±S),而P53基因转染组和Rb基因转染组的细胞迁移距离分别为0.53±0.45cm和0.37±0.29cm,显著低于对照组(P<0.05,P<0.001)。
    It is suggested that introduction of exogenous P 53 gene and Rb gene could markedly inhibit VSMC migration.
    提示外源性P53基因和Rb基因导入可显著抑制血管平滑肌细胞迁移
    Conclusion The exogenous Rb gene can express in the RB transplantation tumor and can partially suppress the growth of the RB tumor in vivo.
    结论外源性Rb基因可在RB移植瘤内表达并部分抑制RB移植瘤的生长。
    METHODS Immunohistochemical method (SABC) was used to detect the p15 and Rb gene expression in 30 cases of HCC.
    方法 用免疫组织化学方法 (SABC法 )检测 p15 ,Rb基因在 30例 HCC标本中的表达 .
    RESULTS Positive rates of p15, Rb gene are 63%, 43% respectively.
    结果  p15基因阳性表达率为 6 3% ,Rb基因阳性表达率为 43% .
    The comparisons of positive rates of p15 and Rb gene expression between tumor grades were P <0.05, P >0.05 respectively. There were no differences between positive rates of p15 and Rb genes in HCC ( P >0.05).
    p15 ,Rb基因阳性表达率在肿瘤分级间比较分别为 P<0 .0 5 ,P>0 .0 5 .p15 ,Rb基因在 HCC中阳性表达率无差异 (P>0 .0 5 ) .
    AIM To investigate distribution of polymorphism of Rb gene intron 20 VNTR in the aged and whether there is change between youth and the aged in polymorphism of Rb gene intron20 VNTR, To study whether polymorphism of Rb gene VNTR is associated with cellular aging.
    目的 探讨老年人群 Rb基因 2 0内含子的 VNTR多态性分布 ,并与青年群体比较是否发生改变 ,以此研究老年人的衰老机制 .
    Results (1) Two fragments of alleles (945 bp, 630 bp+315 bp) of Rb gene (intron17) were found in old population, with genotype frequency being A/A 0 20, A/B 0 45, B/B 0 35, showing no significant difference between the aged and the youth.
    结果 在老年组中 ,Rb基因 17内含子位点共检测出 2个等位基因片段 :945bp(A)及 6 30 +315bp(B) ,基因型频率 :A/A0 2 0 ,A/B 0 45 ,B/B 0 35 ,等位基因频率 :A 0 43,B 0 5 7;
    MethodsThe expression of p16 gene and Rb gene was measured by flow cytometry in 32 cases of GBMs.
    方法 应用流式细胞仪检测32 例胶质母细胞瘤标本中p16 、Rb 基因蛋白表达的相对含量。
    ConclusionThe abnormalities of expression p16 gene and Rb gene are the important factors for the development of GBMs.
    结论p16 基因和Rb 基因表达活性降低是胶质母细胞瘤发生发展的重要因素之一。
    Purpose To study p16 and Rb gene mRNA expressions and their relationships to lung cancer.
    目的 :研究 p16和Rb基因在mRNA水平的表达及其与肺癌的关系。
    Maybe there is a mechanism at gene translation level which leads to the inactivation of p16 or Rb gene protein.
    在翻译水平上也存在着引起 p16和Rb基因蛋白失活的可能机制。
    Conclusion The result indicated the mutation or lack of RB gene was not the only reason in the tumorigenesis of LSCC, and protein RB might cooperate with cyclin D 1, P16, CDK4 to play a role in the process of tumorigenesis.
    结论 细胞调控周期中Cyclin D1、RB、P16、CDK4等因素在喉鳞癌的发生发展中可能起着协同作用,而并非主要由于RB基因的突变和缺失造成细胞癌变。
    Methods c-myc oncogene protein and Rb gene protein expression in 40cases of oral SCC and 10 cases of leukoplakia as well as 14 cases of lichen planus were quantitatively studied by flow cytometry and cellular immunofluorescence staining technique.
    方法 采用流式免疫荧光技术对 40例口腔鳞状细胞癌 ,10例口腔白斑和 14例口腔扁平苔藓中C -myc和Rb基因蛋白的表达量进行定量研究。
    Objective [WT5”BZ]To investigate the effect of exogenous Rb gene on the cell cycle of vitreous retinoblastoma (RB) transplantation tumor in nude mouse.
    目的 观察外源性视网膜母细胞瘤基因 (Rb基因 )对视网膜母细胞瘤 (retinoblastoma,RB)移植瘤细胞周期的影响。
    [WT5”HZ]Methods [WT5”BZ]Based on establishing vitreous RB transplantation tumor in nude mouse,constructing retrovirus vector of Rb gene PBabe Rb and transfecing it into the RB transplantation model by liposome Dosper,the change of cell cycle of the RB transplantation tumor by flow cytometry(FCM)was analysed.
    方法 在建立裸鼠眼玻璃体腔 RB移植瘤模型及构建 Rb基因的逆转录病毒表达载体 PBabe- Rb的基础上 ,用脂质体 Dosper介导法将 Rb基因导入裸鼠 RB移植瘤 ,流式细胞仪检测 RB移植瘤细胞周期变化。
    Method:Expression of PCNA,p53,and Rb gene proteins was examined by immunohistochemistry in 127patients with mesenchymal tumors.
    方法:采用免疫组织化学LSAB法检测127例间叶组织肿瘤恶性组85例,良性组42例PCNA、p53、Rb基因产物表达情况。
    Results:The positive expression rates of PCN A,p53,and Rb gene proteins were 84.7%(72/85),54.1%(46/85),58.8%(50/85)in the malignant group,but were 40%(17/42),16.7%(7/42),21.4%(9/42)in the benign group,respectively.
    结果:PCNA、p53、Rb基因产物在恶性组中的阳性表达率分别为84.7%72/85,54.1%46/85,58.8%50/85; 良性组中分别为40%17/4216.7%7/42,21.4%9/42。
 

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