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    Conclusion The expression of PPARγ and RXRα in MGC803,SMMC7721 and LOVO cell lines predicts them response to pioglizatone and 9-cis-retinoic acid treatment,the inhibitory effect is different in these three kinds of cell lines,it may be related to ligands-mediated signal pathway.
    结论在MGC803、LOVO和SMMC7721肿瘤细胞中,MGC803细胞PPARγ和RXRα表达最强,这对配体发挥作用可能是必需的,配体发挥的抑制细胞生长的效应可能与其介导的信号途径有关。
    Expression of interleukin-8 and its receptor in acute promyelocytic leukemia under alltrans retinoic acid treatment.
    急性早幼粒细胞白血病全反式维甲酸治疗时IL-8及其受体表达的观察
    A full-length cDNA(RA538) was isolated from human esophageal cancer cell line EC8712 after retinoic acid treatment.
    从人食管癌细胞系(EC8712)分离到一个维甲酸激活的全长cDNA(RA538)。
    Objective To analyze the protein expression in myeloid leukaemia cell line HL60 with retinoic acid treatment.
    目的 以维甲酸诱导急性早幼粒白血病细胞HL60分化为模型 ,用双向电泳技术分析比较维甲酸诱导HL60细胞分化的蛋白表达差异。
    Methods Altogether 100 female SD rats were divided randomly into 5 groups:the control group (N),irradiation alone group(S),retinoic acid treatment group(W),retinoic acid and fluvastatin treatment group(L),and dexamethasone treatment group(D). Each group had 20 rats.
    方法 健康雌性SD大鼠 10 0只随机分为 5组 :正常对照组 (N)、单纯照射组 (S)、维甲酸治疗组 (W)、维甲酸 +氟伐他汀治疗组 (L)、地塞米松治疗组 (D) ,每组 2 0只。
    AIM:To study the function of interleukin- 8(IL- 8) in generation and develo pment of radiation lung injury in rats and the effects of retinoic acid and fluv astatin on the expression of IL- 8. METHODS:Eighty female SD rats were randomly divided into four groups:control group,radiation group,retinoic acid treatment group and retinoic acid combined w ith fluvastatin treatment group(n=20).
    目的:研究白细胞介素8(interleukin-8,IL-8)在大鼠放射性肺损伤发生、发展中的作用和维甲酸、氟伐他汀对其影响。 方法:健康雌性SD大鼠80只随机分为4组:正常对照组、单纯照射组、维甲酸治疗组、维甲酸联合氟伐他汀治疗组,每组20只。
    The results of immunohistochemistry an d ISH were measured by image analysis system. RESULTS:The expression of interleukin- 8 mRNA enhanced significantly in radi ation group at 5 day(F=12,P< 0.01),and weakened in retinoic acid treatment group and retinoic acid combined with fluvastatin treatment group(F=13,22, P< 0.01).
    结果:照射组照射后5d,IL-8mRNA表达明显增强(F=12,P<0.01),维甲酸组、维甲酸联合氟伐他汀组5d明显减弱(F=13,22,P<0.01);
 

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