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    The TNF level in subacute fulminant hepatitis (19.38±13.25u/ml) increased significantly than chsonic active hepatitis (2.68±0.86n/ml), acute hepatitis (2.17±0.05u/ml) and healthy donors (<2u/ml) P<0.05.
    结果表明,重症肝炎组TNF(19.38±13.25u╱ml)较慢性活动性肝炎组(2.68±0.86u/ml)、急性肝炎组(2.17±0.05u/ml)及正常对照组(<2u/ml)明显升高,P<0.05。
    Fifty eight cases of acute and subacute fulminant hepatitis admitted in this hospital from March 1987 to June 1990 were observed.
    本文观察了我科自1987年3月~1990年6月收治的58例急性、亚急性重症肝炎的内毒素血症对疾病的发生、发展及预后估计的作用。
    Activity of peripheral blood monoueclear cell tumor necrosis factor(TNF) induced by lipopolysaccharide (LPS) was determined in patients with subacute fulminant hepatitis, chronic active hepatitis, acute hepatitis and healthy donors by use of crystal violet-staining method.
    应用结晶紫染色法检测重症肝炎、慢性活动性肝炎、急性肝炎患者及正常献血者外周血单核细胞经内毒素诱生的肿瘤坏死因子(TNF)活性,以探讨血TNF与重症肝炎的关系。
    Patients with acutehepatitis(AH),chronic hepatitis(CH)were more young than that with subacute fulminant hepatitis(SAFH),cirrhosis(Ci)and HCC,the peak of age were 20~29 and 40~49 respectively.
    亚急性重症肝炎(SAFH)和肝硬化(Ci),原发性肝细胞肝癌(PHCC)为40~49岁组。
    The case-fatality rate of fulminant HBV was higher than that of both fulminant HAV and HCV. The prognoses of both chronic and acute fulminant hepatitis were worse than that of subacute fulminant hepatitis.
    乙型重肝较甲型重肝、丙型重肝病死率高。 慢性重肝、急性重肝较亚急性重肝预后差。
    The result was six of the twenty—two patients were positive for HGV RNA. The infection rate was 27.3%,in which subacute fulminant hepatitis was 36.4%(4/11) for HGV RNA positive,chronic fulminant hepatitis was 20.0%(2/10) for HGV RNA positive.
    结果发现22例重肝患者血清标本中检出6例HGVRNA阳性,阳性率27.3%,其中亚急性重型肝炎11例,HGVRNA阳性4例,阳性率36.4%,慢性重型肝炎10例,HGVRNA阳性2例,阳性率20.0%,急性重型肝炎1例未检出。
    Results There were 2 12 nucleotide substitutions in CP region in the 7 subacute fulminant hepatitis patients studied. An 11 bp nucleotides insertion was found in one patient.
    结果 7 例亚急性重型肝炎病人的HBV 分离株CP区分别有2~12 个替代变异,1 例病人有11bp 的碱基插入。
    Results There was no difference among acute fulminant hepatitis,subacute fulminant hepatitis and chronic fulminant hepatitis,the level of ALT in HGV positive group was mild lower than that in HGV negative group,but sera bilirubin and globulin were higher than those in HGV negative group,and the mortality rate in HGV positive group was significantly lower than that in HGV negative group.
    结果 各临床类型重肝 HGV感染率无明显差别 ,HGV感染病例 AL T升高较低 ,SB、A/G较高 ,病死率显著低于 HGV(- )病例 ,单纯 HGV感染少见。
 

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