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    The Fip genes of the CAV-2 virulent strain SY-V5,attenuated SY-V60,SY-CP5(derived from SY-V60 pa ssed in susceptible dogs for 5 passages) and USA vaccine strain(US-V20) had bee n sequenced and compared with one another and with that of the standard CAV-2 T oronto virulent strain.
    犬2型腺病毒与 Gen Bank中的标准的 CAV- 2强毒株 (Toronto A2 6 / 6 1)纤突蛋白基因序列的比较结果表明 :CAV- 2 SY株强毒株与 Toronto A2 6 / 6 1株相同 ; SY- V6 0株与 SY- CP5相同 ;
    Guide sequences(GSs) are small RNA molecules that consist of a sequence complementary to a target mRNA and render the target RNA susceptible to degradation by the catalytic RNA subunit of RNase P from Escherichia coli( M1 RNA).
    引导序列GSs(GuideSequences)是能与mRNA互补 ,引导核酶RNaseP催化核心M1RNA对互补区域特异切割的小片段游离RNA。
    AX15 is susceptible to protease degradation when expressed in Pichia pastoris.
    在巴斯德毕赤酵母中表达时AX15易发生降解。
    One strain, C57BL/6 (H-2 b), behaves as HS (high susceptible) with percentages of suppression of 47.8%±3.4% at a Tk concentration of 50 ng/ml.
    根据抑制幅度 ,C5 7BL/ 6 (H 2 b)被判为高易感品系 (HS ,highsusceptible ) ,同属H 2 k 的C3H/He和AKR为低易感品系 (LS ,lowsusceptible)。
    In contrast, the low susceptible strains (LS) C3H/He and AKR, both are H-2 k, only yield suppressions of 15.9%±3.0% and 18.9%±3.5%, respectively.
    Tk浓度为 5 0ng/ml时的T细胞增值抑制百分率对HS为 4 7 8%± 3 4 % ; 对两个LS分别为 15 9%± 3 0 %和 18 9%± 3 5 % ,两组间差异显著 (P <0 0 0 1)。
    Results MIC test show these strains were 100% susceptible to imipenem , 84.4% to cefepime,71.9% to piperacillin/tazobactam, 70.3% to ciprofloxacin.
    其次为头孢吡肟 (84.4% ) ,哌拉西林 /他唑巴坦和环丙沙星的敏感率则分别为 71.9%和 70 .3 %。
    HLA-DQ5; HLA-DR17 and HLA-DQ8 gene may be a putative susceptible for the combination of haplotype for patients with keloid.
    HLA DQ5、HLA DR1 7和HLA DQ8基因可能是瘢痕疙瘩患者易感的单倍型
    It was found that, under the action of Tk, the amounts of IL-4 and IL-10 in the high-susceptible strain o f mice, C57BL/6(H-2b), were obviously increased, bu t that of IFN-γ markedly decreased.
    发现Tk作用下 ,高易感品系C5 7BL/ 6 (H 2 b)IL 4、IL 10分泌量大幅度增高 ,IFN γ显著下降 ;
    The GMTs of antibodies of types H 1N 1,H 3N 2 and B in non-susceptible subjects in trial group increased by 18.28,9.30 and 8.61 folds,while those in control group increased by 18.16,8.45 and 5.77 folds respectively.
    非易感者免后H1N1、H3 N2 、B型抗体GMT与免前相比 ,试验组分别为免前的 18 2 8、9 30和 8 6 1倍 ,对照组分别为免前的 18 16、8 4 5和 5 . 77倍。
    MICs of ampicillin against lactamase-producing isolates decreased by 10-40 and 10-20 times, respectively, when it was conbined with sulbactam at ratio of 1 2 and 1 4. All clinical isolates were susceptible to third-generation cephalosporins.
    氨苄西林与舒巴坦以2∶1、4∶1配比联用时,其对分离产酶菌的MIC值分别降低10~40倍、10~20倍。
    Results MP4 was 100 fold less susceptible to PZ neutralization as compared to A2. The F protein gene of MP4 had a nucleotide substitution (base 828 A to T) that resulted in a coding change (amino acid 272 Lys to Met).
    结果 与A2母株比较 ,MP4于F基因 82 8位核苷酸发生突变 (A→T) ,导致 2 72位推导氨基酸由赖氨酸变为甲硫氨酸。
    The region ⅡS4-ⅡS6 of the sodium channel gene fragment was amplified from deltamethrin-susceptible and resistant strains of Culex pipiens pallens by RT-PCR with degenerate primers,which was composed of 359bp.
    本研究采用RT -PCR技术,使用简并引物分别从淡色库蚊(Culexpipienspallens)敏感品系和抗溴氰菊酯品系中扩增出钠通道ⅡS4~ⅡS6区域的基因片段,长度为35 9bp。
    albicans in this region. Heterogeneities at position -365, -353, -328, -310, -308, -299, -295, -293, -292, 290, -289 and a single base deletion (-284 delT) were found on one allele of ERG11 promoter region of fluconazole-susceptible substrains.
    氟康唑敏感株白念珠菌ERG11基因启动子的-365,-353,-328,-310,-308,-299,-295,-293,-292,290,-289位点为杂合状态,且在-284位点有一等位基因发生单碱基缺失(-284delT);
    The average subordinate values of the former three populations with resistance to drought stress were 0.766, 0.689 and 0.658, while the later was susceptible with the value of 0.065. Fig 2, Tab 3, Ref 23
    结果表明,LP、PZH、YJ种群较为耐旱,耐旱隶属函数总平均值分别0.766、0.689、0.658,SM种群则较为敏感,耐旱隶属函数总平均值为0.065.图2表3参23
    rpoB gene mutations were not found in all the 117 susceptible strains.
    TB临床分离株中rpoB基因突变的发生率平均为71·4%,所有受试117株敏感株rpoB基因均无突变。
    The GMTs of antibody of susceptible children immunized with 39810,2000 and 500 PFU of vaccine were 36.4,34.3 and 18.6,and their antibody positive conversion rates were 100%,98.77% and 85.42% respectively.
    易感者接种39810PFU、2000PFU以及500PFU病毒量的疫苗后,抗体GMT分别为36.4、34.3和18.6; 抗体阳转率分别为100%、98.77%和85.42%。
    The presence of tetM gene in tetracycline resistant strains was higher(96.9%) than those in tetracycline susceptible strains(26.9%).
    tetM基因在分离株中的阳性率是87%,四环素耐药组的tetM基因携带率是96.9%,高于敏感组(26.9%)。
    Objective:To construct the phage display library of randomized P2/NC protease cleavage sequences in HIV-1 Gag protein,so as to provide evidences for studying the effect of drug resistance-associated mutations on susceptible cleavage sequences of HIV-1 PR.
    目的:构建HIV-1 Gag PR蛋白P2/NC切割位点序列随机化的噬菌体展示文库,研究HIV-1蛋白酶(protease PR)耐药性突变对其敏感切割序列的影响。
    METHODS The genes of gyrA and parC DNA in 28 ciprofloxacin-resistant and 2 ciprofloxacin-susceptible isolates of A. baumannii were amplified by PCR and then analyzed by restriction fragment length polymorphism(PCR-RFLP) and DNA sequencing.
    方法收集28株耐药株及2株敏感株,通过PCR扩增其gyrA基因及parC基因,并对扩增产物进行限制性片段长度多态性分析(PCR-RFLP)及DNA序列分析。
    DNA sequencing of 5 resistant isolates revealed mutations in gyrA gene that resulted in amino acid substitutions: Ser83→Leu and Ala88→Thr,especially,Ser83 point mutation accounting for the disappearance of sequence of Hinf Ⅰ. There was not any mutation in(gyrA) of 1 susceptible isolate;
    DNA测序显示,5株耐药株gyrA基因存在Ser83→Leu及Ala88→Thr突变,其中Ser83→Leu的突变是导致HinfI酶切位点消失的原因,而1株敏感株无突变;
 

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