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    STUDY ON THE VACUUM ULTRAVIOLET SPECTRA FROM A TARGET PLASMA
    靶等离子体真空紫外光谱研究
    Anesthesia was induced with proprofol and vecuroninm. After the tracheal intubation, the patients were ventilated with 0.6/1.0 MAC isoflurane in pure oxygen, and after 20 minutes, propofol was administered with TCI according to the different target plasma concentrations from 1.0 g/mL to 3.0 g/mL(increasing 0.5 g/mL each time).
    异丙酚和维库溴铵诱导气管内插管后,吸入异氟醚,呼末浓度分别为0.6/1.0MAC,稳定20min后靶控输注异丙酚,靶浓度从1.0μg/mL开始,以0.5μg/mL递增,靶浓度稳定在3.0μg/mL开始手术。
    Results There was no close correlation between MAP, HR and the end-tidal isoflurane concentration, target plasma concentration of propofol.
    结果:MAP和HR的变化与异氟醚呼末浓度和异丙酚浓度无相关性。
    those between BIS, AEPindex and the target plasma concentration of propofol were -0.932,-0.888 and -0.920,-0.923 (P<0.001).
    与异丙酚靶控浓度的相关系数分别为-0.932,-0.888和-0.920,-0.923(P<0.001)。
    Conclusion When BIS reached to 45±3,The target plasma concentration of fentanyl above 3.0 ng·mL-1 may attenuate the stress responses to tracheal intubation and fentanyl TCI concentration at 3.5 ng·mL1 can inhibit the BIS rise caused by tracheal intubation with stable hemodynamics.
    结论在BIS值达到45±3的镇静深度下,芬太尼TCI血浆目标浓度达到3.0 ng. mL-1可有效预防气管插管应激反应,在血浆目标浓度达到3.5 ng.
    ECG, invasive BP, HR, and SpO2 were monitored before and during anesthesia. The patients were randomized to receive remifentanil by TCI at target plasma concentrations of 1, 2, 3, 4, 5 and 6 ng·ml-1( n = 10 each) . It takes 5-6 min to achieve the balance between the plasma and effect-site concentration.
    方法择期全麻手术病人60例,ASAⅠ或Ⅱ级,年龄加~65岁,体重40~75 kg,随机分为6组(n=10):瑞芬太尼靶控输注(TCI),血浆靶浓度分别为1、2、3、4、5、6 ng/ml;
    TCI of remifentanil was suspended at 2 min after intubation and restarted at 10 min before skin incision at the same target plasma concentration before intubation.
    插管后2 min暂停瑞芬太尼TCI,切皮前10 min再以诱导时相同浓度瑞芬太尼TCI。
    When the target plasma concentration was more than 1 ng/ml PIFR was significantly decreased and the inspiratory time fraction was significantly prolonged in both groups.
    与瑞芬太尼血浆靶浓度为1 ng/ml时比较,2组血浆靶浓度为2、3 ng/ml时PIFR均降低,T_I/T_T增加(P<0.05)。
    The propofol was maintained at a target plasma concentration of 3 μg/ml.
    丙泊酚血浆靶浓度均为3μg/ml,与舒芬太尼同时靶控输注,直至气管插管后5min停止输注。
    Tracheal intubation was performed with scopolamine 0.3 mg,midazolam 0.05 mg/kg,fentanyl 2 μg/kg,vecuronium 0.08 mg/kg bromide and propofol at a fixed target plasma concentration of 8 μg/ml.
    D组:为对照组,无任何表面麻醉。 诱导方法:东莨菪碱0.3mg、咪达唑仑(咪唑安定)0.05mg/kg,芬太尼2μg/kg、维库溴铵0.08mg/kg、丙泊酚采用血浆靶控8μg/ml输注。
    Feasibility of application of propofol target plasma concentration and effect-site concentration to predict sedation level
    丙泊酚预期血药浓度和效应室浓度用于判断镇静深度的可行性研究
    FDTD Analysis on the Effects of Plasma Temperature and Density on Target Plasma Stealth
    温度、密度对目标等离子体隐身效果影响的FDTD分析
    In group Ⅱ, target plasma concentration of 4ug. ml-1 was infused by ‘ Diprifusor ’ system firstly. And then target plasma concentration of 1.5ug.
    Ⅰ组用异丙酚2mg/kg,Ⅱ组用Diprifusor靶浓度控制输注异丙酚, 靶浓度(Ct)设为4ug/ml自行诱导量后调整为1.5ug/ml。
    Methods: Forty ASA I or II patients aged 40-60yr and weighed 52-74kg undergoing pulmonary lobectomy or segmentectomy were randomly divided into 2 groups (n=20 each) according to target plasma concentration of remifentanil: group R6 (6ng/ml) and group R8 (8ng/ml) .
    方法:择期全麻下行肺叶或肺段切除术胸科手术患者40例,ASA Ⅰ或Ⅱ级,年龄40~60岁,体重52~74kg。 根据瑞芬太尼血浆靶浓度不同,随机分为2组:R6组(6ng/ml)、R8组(8ng/ml)。
    Objective To investigate the relationship between the depth of midazolam induced sedation and the target plasma concentration(Cp),the effect site concentration(Ce) or electroencephalogram(EEG)parameters during regional anesthesia.
    目的 探讨咪唑安定 (MDZ)靶控输注镇静时目标血药浓度、效应室浓度与脑电指标双频指数 (BIS)、95 %边缘频率 (95 %SEF)预测镇静深度的临床价值及MDZ在区域麻醉靶控输注镇静中的适宜目标浓度。
    The patients were unpremedicated. Anesthesia was induced with remifentanil and propofol both given by TCI simultaneously. The patients were randomized to receive remifentanil at a fixed target plasma concentration of 0, 2, 4, 6 or 8 ng · ml-1 (group R0, R2, R4, R6, R8) .
    方法 50例择期全麻手术病人按瑞芬太尼的血浆靶浓度随机分为5组(R0、R2、R4、R6、R8组),即0、2、4、6、8 ng/ml组。
    The target plasma concentration of propofol was decreased to 3.3μg/ml after the patients lost consciousness.
    病人意识消失后 ,静注维库溴铵 0 .1mg/kg,然后把异丙酚血浆目标浓度降为3.3μg/ml维持麻醉。
    The patients were randomized to receive fentanyl by TCI at a target plasma concentration of 1.0, 1.5, 2.25 or3.38 ng·ml-1 . The target plasma propofol concentration was set at 3 μg·ml-1 in all patients.
    麻醉诱导时通过TCI系统使所有病人异丙酚血浆靶浓度达到和维持3μg/ml,使各组芬太尼的血浆靶浓度分别达到1.00、1.50、2.25、3.38 ng/ml。
    while the women in group Ⅱ,Ⅲ,Ⅳ accepted 30-second injection of Remifentanil ( 0.3 μg/kg) 1 min before intravenous propofol, the target plasma propofol concentration of these three groups set at 5.0 mg/L,5.5 mg/L,6.0 mg/L respectively. The operation began after eyelash reflex vanished, and infusion stopped at the end of the suction of cavity of uterus.
    Ⅱ、Ⅲ、Ⅳ组在输注异泊酚前 1min先静脉注射REM 0. 3μg/kg,注射时间为 30s,异泊酚血浆靶浓度分别设定为 5. 0mg/L、5. 5mg/L和 6. 0mg/L,待患者睫毛反射消失后开始操作,吸宫结束时停用异泊酚。
    Results The measured concentrations (Cm) of remifentanil were significantly lower than the target plasma concentration (Cp) at5, 10, 20 min of TCI in both groups ( P < 0.05) .
    结果在TCI 5、10、20 min时,两组瑞芬太尼Cm均低于Cp(P<0.05)。
 

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