Advances in the artificial hydroxamate siderophore analogs developed in recent years were reviewed,and the coordination properties of biomimetic ferrichrome analogs,biomimetic ferrioxamine analogs and biomimetic rhodorulic acid analogs for Fe(III) and their bioactivity were also discussed.
In this work, the relaxation times of the ferrichrome analogue B2 at different Fe(Ⅲ) concentrations have been measured, and the relative distances from Fe(Ⅲ) ion to all the protons have been also worked out by using a simplified solomon-Bloembergen equation. The conformation of this complex in CDC13 solution can be imagined out.
Symport transport of ferrichrome-type siderophores
The energetics of ferrichrome transport by bacterial membranes are explained by a unique structural feature of the metal-laden form of the siderophore which enables complexing of alkaline-earth cations.
The uptake of iron from 55Fe-labeled transferrin, ferric citrate, fusigen, coprogen, ferrichrome, ferricrocin, ferrichrysin, ferrirubin and ferrioxamine B was studied on in vitro cultures of bone marrow cells (Detroit-98).
δ-N-Hydroxy-l-ornithine was incorporated into all sideramines of the fusigen-, diketopiperazine-, and ferrichrome-type with washed mycelia.
The three monohydroxamic acids are either not the precursors of ferrichrome-type sideramines, or they are not transported into the cell.