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大规模制备
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  “大规模制备”译为未确定词的双语例句
    Large-scale Production of Plasmid DNA
    质粒DNA的大规模制备
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    However, research was concentrated on the chiral analysis and chiral recognition mechanism, and the study on the preparative separation is not excessive.
    手性色谱拆分法是发展较快的一种手性分离方法,但目前研究侧重于手性药物的分析与手性识别机理研究,大规模制备的应用研究还很少。
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    The great value is given in the possibility of introducing a chiral vicinal diol and β -amino alcohol moieties from readily available prochiral olefms in a single step.
    目前AD和AA反应虽然可以通过一步反应得到手性化合物,但很少用于手性β-氨基醇和手性邻二醇的大规模制备
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    These disadvantages greatly limit the mass production and its practical application.
    这些缺点限制了层状锂锰氧化物的大规模制备和在实际中的应用。
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    The R&D of enzymatic resolution would be significant for the development of the new types of reaction,immobilization and reuse of enzyme and designing of specific reaction instruments for mass preparation of chiral products.
    指出酶催化手性拆分在不对称合成领域的发展方向将是新的适用反应类型的开发、酶的固定化及重复利用技术,以及大规模制备手性产品的专用反应器的设计等。
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The latest progress in enzymatic resolution was introduced and its methods of enzymatic resolution were classified into hydrolization,oxidation and reduction,group transfer and lyase-catalysed reactions,and synthesis in non-aqueous media.Some examples valuable in either foundation or application were also cited.The factors such as solvent engineering,disposing of enzyme,additives and so on that can possibly enhance the selectivity and yield of enantiomers were discussed.The R&D of enzymatic resolution would...

The latest progress in enzymatic resolution was introduced and its methods of enzymatic resolution were classified into hydrolization,oxidation and reduction,group transfer and lyase-catalysed reactions,and synthesis in non-aqueous media.Some examples valuable in either foundation or application were also cited.The factors such as solvent engineering,disposing of enzyme,additives and so on that can possibly enhance the selectivity and yield of enantiomers were discussed.The R&D of enzymatic resolution would be significant for the development of the new types of reaction,immobilization and reuse of enzyme and designing of specific reaction instruments for mass preparation of chiral products.

将酶催化拆分反应的国内外新进展归纳为水解反应、氧化-还原反应、转移-裂合反应以及非水介质中的合成反应等类型,并列举了其中一些具有重要理论意义或应用价值的实例。探讨了介质工程、预处理酶及添加剂等因素对对映体选择性和产率的影响。指出酶催化手性拆分在不对称合成领域的发展方向将是新的适用反应类型的开发、酶的固定化及重复利用技术,以及大规模制备手性产品的专用反应器的设计等。

AIM: To synthesize methyl 4 fluorocinnamate, which is widely used in asymmetric dihydroxylation and aminohydroxylation, by esterification of 4 fluorocinnamic acid and methanol with strongly acidic cationic exchange resin as catalyst. METHODS: A mixture of appropriate amount of 4 fluorocinnamic acid, methanol and pretreated cationic exchange resin was stirred vigorously and refluxed for 5 h. After the excess of methanol was removed by distillation, the residue was extracted. Resin was recovered by filtration...

AIM: To synthesize methyl 4 fluorocinnamate, which is widely used in asymmetric dihydroxylation and aminohydroxylation, by esterification of 4 fluorocinnamic acid and methanol with strongly acidic cationic exchange resin as catalyst. METHODS: A mixture of appropriate amount of 4 fluorocinnamic acid, methanol and pretreated cationic exchange resin was stirred vigorously and refluxed for 5 h. After the excess of methanol was removed by distillation, the residue was extracted. Resin was recovered by filtration of the organic layers and reused after washing and drying. The combined organic layers were further washed and dried to yield methyl 4 fluorocinnamate. The purity of methyl 4 fluorocinnamate was determined by thin layer chromatography and the product was characterized by melting point, infrared spectrum (IR) and 1H nuclear magnetic resonance spectroscopy (1H NMR). RESULTS: Optimum yield was 97.5% and the melting point, IR and 1H NMR of methyl 4 fluorocinnamate were in accordance with the data reported. CONCLUSION: The esterification with strongly acidic cationic exchange resin as catalyst is cost efficient, less erosive to equipment and can be used for large scale preparation of chiral medicinal materials.

目的 :在强酸型阳离子交换树脂的催化下 ,对氟肉桂酸和甲醇酯化合成不对称二羟化和不对称氨羟化反应原料—对氟肉桂酸甲酯 .方法 :将适量对氟肉桂酸、甲醇以及离子交换树脂搅拌均匀、回流 5h .蒸出过量甲醇后 ,萃取剩余物 ,有机相过滤得树脂 .树脂在淋洗、干燥后可重复使用 .合并的淋洗液和滤液经洗涤、干燥以及蒸出溶剂后得对氟肉桂酸甲酯 .产物经红外图谱、核磁共振谱以及熔点鉴定 .结果 :在优化的实验条件下 ,该反应化学产率高达 97.5 % .产物的红外图谱、核磁共振谱以及熔点与文献值相符 ,薄层色谱结果表明产物的纯度高 .结论 :采用固体强酸型阳离子交换树脂作催化剂的酯化反应产率高、成本低、对设备腐蚀小、工艺简化 ,可用于手性药用原料的大规模制备

The Burkholderia cepecia 1003 screened by the authors' laboratory,which contains hydantoinase and N -carbamoylase activities,was used to prepare D-phenylalanine on a large scale. The dynamic parameters of the whole bioconversion process were measured,and the results showed that k _r was 3.975×10 -3 min -1 ,K _ m and r _m of hydantoinase and N -carbamoylase were 16.7894 mmol·L -1 ,0.82688 mmol·L -1 ,0.6127 mmol·L -1 ·min -1 and 4.828×10 -4 mmol·L -1 ·min -1 ,respectively.Simulation...

The Burkholderia cepecia 1003 screened by the authors' laboratory,which contains hydantoinase and N -carbamoylase activities,was used to prepare D-phenylalanine on a large scale. The dynamic parameters of the whole bioconversion process were measured,and the results showed that k _r was 3.975×10 -3 min -1 ,K _ m and r _m of hydantoinase and N -carbamoylase were 16.7894 mmol·L -1 ,0.82688 mmol·L -1 ,0.6127 mmol·L -1 ·min -1 and 4.828×10 -4 mmol·L -1 ·min -1 ,respectively.Simulation was made including processes of dissolution,racemization,hydrolysis of D-BH and hydrolysis of N -carbamyl phenylalanine.The significance of parameters in this model was investigated and these parameters were optimized. The result showed that the reaction rate of D-BH hydrolysis was higher than that of N -carbamyl phenylalanine hydrolysis,the latter was the limiting step of the whole process. Promotion of N -carbamoylase activity was helpful to D-phenylalanine production. Another result was that the rate of L-BH racemization was the main factor,which influenced the conversion of racemic BH.

采用自行筛选的兼有海因酶和N 氨甲酰氨基酸水解酶活性的Burkholderiacepecia 10 0 3菌种 ,利用海因酶法大规模制备D 苯丙氨酸 ,对其中涉及的各过程的动力学参数进行了测定 .结果表明 :L 苄基海因的消旋速率常数为 3 975× 10 -3 min-1;海因酶的米氏常数为 16 7894mmol·L-1,最大反应速率为 0 6 12 7mmol·L-1·min-1;N 氨甲酰氨基酸水解酶的米氏常数为 0 82 6 88mmol·L-1,最大反应速率为 4 82 8× 10 -4mmol·L-1·min-1.对DL 5 苄基海因的溶解、L 苄基海因的消旋、D 海因的水解开环及其中间产物 (N 氨甲酰苯丙氨酸 )的水解脱酰氨过程建立了动力学模型 ,并在此基础上进行了动力学参数显著性分析和优化 .结果表明 :对于这一级联酶转化反应 ,D 海因酶的水解反应是快速反应 ,而N 氨甲酰氨基酸脱氨甲酰的反应速率极小 ,是该过程的控制步骤 .提高氨甲酰水解酶的活力将有助于提高总体的转化速率 ,而L 海因的消旋速率则是影响外消旋苄基海因转化率的主要因素 .

 
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