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Opioid receptors of μ, δ, and κ types are involved in the mechanisms of combined regulation of pain and immunity, with μ and δ receptors suppressing the immune response and κ receptors enhancing it.
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We studied the effect of naloxone-an antagonist of the opioid receptors-on sensitivity of Cl--activated Mg2+-ATPase from the plasma membrane fraction of bream brain (Abramis brama L.) to GABAa-ergic substances.
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In particular, attention was focused on their ability to change the activity of enkephalin-degrading enzymes of blood serum and interact with opioid receptors of the brain membrane fraction.
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The interaction between the peptides and opioid receptors was estimated using a radioreceptor method with [3H][D-Ala2, D-Leu5]-enkephalin.
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No interaction was observed between the peptides and μ- or δ-opioid receptors of the membrane fraction from the rat brain.
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