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  carcinoma
Immunohistochemical analysis revealed a high expression level of hSef in kidney, testis, and the corresponding carcinoma tissues.
      
Effect of down-regulating VEGF on proliferation of colon carcinoma cell HT-29
      
Cancer-related genes harbored in the loss regions containing a high frequency of hepatocellular carcinoma (HCC) were selected.
      
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We recognized and honoured the important contributions of these Chinese pioneers in portal hypertension, recurrent pyogenic cholangitis, hepatocellular carcinoma and liver transplantation.
      
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On analysing the biological data of the recent years,a hypothesis of chromosomal sectional activity has been produced which manifested as:(1)During the individual development,the chromosome proceed its sectional activity regularly with its different components.(2)The sectional activity is uninverseable and the specificity is proved gradually in the individual development.The activationer of the activity is found to be the hormone and the suppressor histone.(3)Chromosome is a sort of essential genetic material,but...

On analysing the biological data of the recent years,a hypothesis of chromosomal sectional activity has been produced which manifested as:(1)During the individual development,the chromosome proceed its sectional activity regularly with its different components.(2)The sectional activity is uninverseable and the specificity is proved gradually in the individual development.The activationer of the activity is found to be the hormone and the suppressor histone.(3)Chromosome is a sort of essential genetic material,but far from the doctrine of Mendel-Morgan's chromatophore of gene.This was confirmed by the sectional activity of chromosomal component was not in accordance with the proceedings of the character differentiation.The activity of the chromosome has provided with different material basis and the processes for the character differentiation.Lastly,by applying the hypothesis,it is hoped to render some new explanations to the principles of Mendelian genetics,the matrilineal inheritance,the corresponting stage inheritance as well as in the cases concerning cancers.

根据近年来有关的理论及实验资料,对染色体在遗传发育中的活动规律进行了分析,提出一个染色体阶段活动假说。认为染色体不是与性状一一对应的基因的载体,染色体上遗传单位的活动与性状分化不是一回事。在个体发育中染色体是以不同组份(或单位),循序进行着不同质的阶段活动,从而控制着性状分化的程序。并根据这个假说对遗传、发育、等提出了新的解释,以说明它对生物学理论与实践的意义。

Radix trichosanthes is an abortifacient drug of mid-gestation and is extracted from the root tuber of Trichosanthes kirilowii Maxim (Cucurbitaceae).The purified effective principle is a basic protein of molecular weight of appoximately 18,000 and is named "Trichosan'thin".It is proved to be very effective in abortion induction of mid-gestation,particularly effective in treating ectopic pregnancy,hydatidiform mole and invasive mole,and it has also some therapeutic action on choriocarcinoma.Based upon the experimental...

Radix trichosanthes is an abortifacient drug of mid-gestation and is extracted from the root tuber of Trichosanthes kirilowii Maxim (Cucurbitaceae).The purified effective principle is a basic protein of molecular weight of appoximately 18,000 and is named "Trichosan'thin".It is proved to be very effective in abortion induction of mid-gestation,particularly effective in treating ectopic pregnancy,hydatidiform mole and invasive mole,and it has also some therapeutic action on choriocarcinoma.Based upon the experimental results on its initial site of action,its morphological and functional injury on trophoblast cells of placenta both in vivo and in,vitro and its effect on prostaglandin synthesis,the following conclusions are drawn concerning the mechanism of abortifacient action of triohosanthin:(1)Trichosanthin exerts its action directly on the placental trophoblasts and possesses a certain degree of specificity.(2)It selectively produces necrotic degeneration of the syneytiotrophoblasts of placental villi,resulting in fragments of the disintegrated cells clumped in the blood sinus,and the coagulation of blood causing circulation hinderan'ce and followed by large scale tissue necrosis.The necrosis of placental villi is considered to be the primary response.(3)Beside structural injuries the impairemerit of functional activities were also observed.The concentrations of HCG and steroid hormones fell rapidly below the threshold values of threatened abortion.Serious structural and functional injuries brought about destructive effects upon the normal endocrine relationship between the mother and fetus and upon metabolic exchanges.It was further postulated that through certain unknown mechanism the synthesis of prostaglandin was increased,uterine contraction was initiated and abortion ensued.In summary,trichosanthin,a plant protein discovered from Chinese medical herbs,is a drug for abortion induction and also a drug against trophoblastie neoplasms.The preliminary elucidation of the mechanism of this drug on abortion induction has afforded basis for the clinical application with better efficacy and its possible use for an abortifacient in early pregnancy as well as for the discovery of newer cancer chemotherapeutie agents.

天花粉粗提物是从葫芦科植物栝楼的根提取出的中期引产药物,其纯化的引产有效成分为分子量约18,000的碱性蛋白质,称为“天花粉蛋白”。经鉴定对中期妊娠有很好的引产效果。同时,对宫外孕、葡萄胎、恶性葡萄胎有独特的疗效,对绒毛膜上皮也有一定的疗效, 根据对天花粉蛋白的原初作用部位,胎盘和离体培养的人滋养层细胞的形态和功能损伤,以及抑制前列腺素合成对天花粉蛋白引产的影响等方面的研究结果,互相印证,初步阐明了天花粉蛋白引产作用原理:(1)天花粉蛋白直接作用于胎盘的滋养层细胞,并有一定的细胞专一性:(2)天花粉蛋白能选择地使胎盘绒毛合体滋养层细胞变性坏死,解体的细胞碎片留在血窦中,引起凝血,造成循环障碍和进一步的大量组织坏死,胎盘绒毛坏死是原发的,循环障碍是继发的:(3)胎盘绒毛的损伤反映在功能方面,HCG和甾体激素迅速下降到先兆流产的临界水平以下。由于胎盘形态和功能严重损伤的结果,破坏了母体和胎儿之间的内分泌关系和代谢物的交换,并假定可能通过尚未弄清楚的机制,引起前列腺素合成的增加,发动宫缩而导致流产。总之,天花粉蛋白是从中草药发掘出来的一个植物蛋白性的中期引产和抗增生性滋养层细胞疾病的药物。天花粉蛋白引...

天花粉粗提物是从葫芦科植物栝楼的根提取出的中期引产药物,其纯化的引产有效成分为分子量约18,000的碱性蛋白质,称为“天花粉蛋白”。经鉴定对中期妊娠有很好的引产效果。同时,对宫外孕、葡萄胎、恶性葡萄胎有独特的疗效,对绒毛膜上皮也有一定的疗效, 根据对天花粉蛋白的原初作用部位,胎盘和离体培养的人滋养层细胞的形态和功能损伤,以及抑制前列腺素合成对天花粉蛋白引产的影响等方面的研究结果,互相印证,初步阐明了天花粉蛋白引产作用原理:(1)天花粉蛋白直接作用于胎盘的滋养层细胞,并有一定的细胞专一性:(2)天花粉蛋白能选择地使胎盘绒毛合体滋养层细胞变性坏死,解体的细胞碎片留在血窦中,引起凝血,造成循环障碍和进一步的大量组织坏死,胎盘绒毛坏死是原发的,循环障碍是继发的:(3)胎盘绒毛的损伤反映在功能方面,HCG和甾体激素迅速下降到先兆流产的临界水平以下。由于胎盘形态和功能严重损伤的结果,破坏了母体和胎儿之间的内分泌关系和代谢物的交换,并假定可能通过尚未弄清楚的机制,引起前列腺素合成的增加,发动宫缩而导致流产。总之,天花粉蛋白是从中草药发掘出来的一个植物蛋白性的中期引产和抗增生性滋养层细胞疾病的药物。天花粉蛋白引产作用原理的初步阐明,在实践上为提高和扩大天花粉蛋白的?

It was found in the present study that thyroxine seemed to play an important role in the regulation of activities of the proliferating enzyme,ACT and the tissue-specific enzymes,CPS1 and OCT in the liver of rats-The effects of thyroxine on the activities of these two different functional enzymes were contradictory.During the development of rats,thyroxine caused an increase of the relative activity of ACT in the liver at two weeks after hirth,with a decrease of that of CPS1 and OCT at the same time.A reverse...

It was found in the present study that thyroxine seemed to play an important role in the regulation of activities of the proliferating enzyme,ACT and the tissue-specific enzymes,CPS1 and OCT in the liver of rats-The effects of thyroxine on the activities of these two different functional enzymes were contradictory.During the development of rats,thyroxine caused an increase of the relative activity of ACT in the liver at two weeks after hirth,with a decrease of that of CPS1 and OCT at the same time.A reverse manner was,however,noted there after till 10 weeks of age.The pattern of changes in the effects of thyroxine on the enzyme activities during hepato-eareinogenesis induced by diethylnitrosamine was somewhat similar to that observed during post-natal development.Based on the results obtained in the current work,the stage of malignant transformation,as defined in our previous report,could be further divided into two substages:the early stage of malignant transformation (i.e.,the stage of hepatocytes undergoingmalignant transformation)......from the 6th to the 12th week of feeding DBNA,andthe late stage of malignant transformation (i.e.,the stage of formation of cells of hepato-cellular carcinoma)......from the 12th to the 16th week of DBNA feeding.In the early stage of malignant transformation,the effect of thyroxine on the relative ratio of activites of CPS1/ACT and OCT/ACT was decreased,while that of ACT/CPS1 and ACT/OCT was increased.But in the late stage of malignant transformation,a reverse situation was observed in which the induction of CPS1 and OCT activities by thyroxine would suggest a possible role of thyroxine on the stimulation of differentiation of cells of hepato-cellular carcinoma.

本实验观察到甲状腺素具有调节肝细胞增殖酶ACT及组织特异酶CPS_1,及OCT活性的功能,当甲状腺素引起新生二周鼠肝ACT的相对活性增高时,CPS_1及OCT的相对活性降低,但对新生二周以后至成年(10周)鼠肝酶活性的影响则相反。对年龄较大如30周的动物几无影响。甲状腺素对DENA诱发大鼠肝过程中肝内上述酶活性的相互影响,与发育过程的情况颇为相似。根据甲状腺素对DENA引过程中酶活性的影响,似可将前一报告中所划分的变期进一步分为变早期(即肝细胞进行变期)——喂 DENA 6—12周,及变后期(即细胞形成期)——喂DENA 12—19周。在变早期,甲状腺素对肝内CPS_1及OCT活性的诱导效应下降:对CPS_1/ACT及OCT/ACT活性相对比值的影响下降,同时对ACT/CPS_1及ACT/OCT活性相对比值的影响上升。在变后期,甲状腺素又使CPS_1及OCT的相对活性增高;使CPS_1/ACT及OCT/ACT活性相对比值上升,同时使ACT/CPS_1及ACT/OCT活性相对比值下降。 ...

本实验观察到甲状腺素具有调节肝细胞增殖酶ACT及组织特异酶CPS_1,及OCT活性的功能,当甲状腺素引起新生二周鼠肝ACT的相对活性增高时,CPS_1及OCT的相对活性降低,但对新生二周以后至成年(10周)鼠肝酶活性的影响则相反。对年龄较大如30周的动物几无影响。甲状腺素对DENA诱发大鼠肝过程中肝内上述酶活性的相互影响,与发育过程的情况颇为相似。根据甲状腺素对DENA引过程中酶活性的影响,似可将前一报告中所划分的变期进一步分为变早期(即肝细胞进行变期)——喂 DENA 6—12周,及变后期(即细胞形成期)——喂DENA 12—19周。在变早期,甲状腺素对肝内CPS_1及OCT活性的诱导效应下降:对CPS_1/ACT及OCT/ACT活性相对比值的影响下降,同时对ACT/CPS_1及ACT/OCT活性相对比值的影响上升。在变后期,甲状腺素又使CPS_1及OCT的相对活性增高;使CPS_1/ACT及OCT/ACT活性相对比值上升,同时使ACT/CPS_1及ACT/OCT活性相对比值下降。 变后期的影响表明甲状腺素似有促使变了的细胞向正常分化的功能。

 
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