Study on the Relationship between Lymphangiogenesis Matrix Metalloproteinase 2 Expression in Oral Squamous Cell Carcinoma and Cervical Lymph Node Micrometastasis
An Immunohistochemically Quantitative Assessment on the Expression of p53 Protein and PCNA and Infiltration of S-100 Protein Positive Dendritic Cells in Oral Squamous Cell Carcinomas
Objective:To investigate the expression of tumor necrosis factor-α(TNF-α)in the tissues of oral squamous cell carcinoma(OSCC)and its clinical significance.
Results:The expression of MMP-9 was closely correlated with lymph nodes metastasis and TNM stage of OSCC(P<0.05). There was no significant correlation between MMP-9 expression and gender, age or tumor differentiation(P>0.05).
Objective:To investigate the expression of Hpa and its correlation with the microvessel density(MVD) in oral squamous-cell carcinoma(OSCC), thereby learning the function of Hpa in the tumor angiogenesis,invasion and lymph node metastasis.
The purified 19peptide directly inhibited proliferation and migration of murine B16 melanoma cells, SMMC-7721hepatoma carcinoma cells and human umbilical vein endothelial cells (HUVEC).
We recognized and honoured the important contributions of these Chinese pioneers in portal hypertension, recurrent pyogenic cholangitis, hepatocellular carcinoma and liver transplantation.
Guanidine-like compounds have been investigated since the first observations of their therapeutic potential some 30 years ago in fields of cancer and virology.
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
Expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent normal (control) tissue.
With regard to sensitivity, compounds 8f and 9c, f have proved to possess a remarkable activity against leukemia tumor cell lines (GI50?=?3.43-5.03?μM).
Tumor necrosis factor (TNF)-α-converting enzyme (TACE) is the major protease responsible for processing pro-TNF-α from membrane-anchored precursors to secreted TNF-α.
This paper presents one case of total glossectomy and six cases of subtotal and partial glossectomy with transplantation of free forearm flaps to repair and reconstruct tongue defects.In this series, the operation proved successful in six cases, but failed in one only.The operation achieved the desired contour and function of the tongue,The authors have accordingly attempted a new procedure of glossal reconstruction. Prospects concerning improvement of the technique are discussed.
From May 1979 to Oct 1982, 48 infrahyoid myocutaneous flaps (IHMCF) were used for reconstruction after resection of lingual carcinoma in 44 cases, 4 for carcinoma of retromolar buccal mucosa, 3 each for carcinoma of floor of mouth and parotid gland and 1 each for osteosarcoma of mandible and soft tissue sarcoma of face. The operative technique was reported in 1980. Two flaps were used simultaneously in 4 cases of lingual carcinoma. When the width of flap was less than 4.5 cm, primary suture of the donor wou...
Surgical treatment of tongue cancer always results in large or whole tongue defects, which makes swallow, speech and mastication very dificult and causes mental suffering. In order to restore the shape and function of the tongue we have repaired and reconstructed large and whole tongue defects using deltopectoral flap, forehead flap, free forearm f.ap and pectora-lis major myocutaneous flap in 17 patients since 1978. The results are good.Some experience in repairing and reconstruction of tongue defects in d...