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fms基因
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  “fms基因”译为未确定词的双语例句
     Local mRNA Expression of MCSF-1, and its receptor, c-fms, on mitral and tricuspid valves in prosthetic valve endocarditis
     二尖瓣术后感染性心内膜炎早期二尖瓣和三尖瓣MCSF-1及受体c-fms基因表达
短句来源
     CFU-GM was not detected in c-myb-/- group. Real-time PCR analysis showed that there was no change in the gene expressions of β-globin, zeta-globin, Lys, and C-fms in the two groups of c-myb+/+ and c-myb -/-.
     real timePCR分析显示,c -myb 及 c- myb+ +β globin,zeta globin,Lys,C- fms基因表达无显著变化。
短句来源
     The overexpression of fms was only associated with HCC of some rats.
     fms基因过表达仅与个别大鼠肝细胞癌有关。
短句来源
  相似匹配句对
     4 new genes were obtained.
     U基因
短句来源
     The NiCoT gene of S. aureus had been successfully expressed in E.
     外源基因在E.
短句来源
     Amplification of cfms Extracellular Domain from Human Placenta
     人胎盘c-fms胞外功能区基因片段的扩增
短句来源
     The overexpression of fms was only associated with HCC of some rats.
     fms基因过表达仅与个别大鼠肝细胞癌有关。
短句来源
     Flexible Manufacturing System FMS50
     FMS50柔性加工系统
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  fms gene
Detection of Two Polymorphic Sites in the Human c-fms Gene: Allele Frequencies in Several Russian Populations
      
Based on these data, functional significance was assumed for this polymorphism of the c-fms gene.
      
Polymorphism of the second site, which is in the 3"-untranslated region of the c-fms gene, was observed in all Caucasoid and Mongoloid populations examined.
      
Deletion Polymorphism of the Human c-fms Gene Intron 11: Allelic Frequencies in Some Populations of Russia and Possible Function
      
Transcriptional regulation of c-fms gene expression
      
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The peptides from IGF--Ⅱ, IGF--Ⅱ receptor (IGF--Ⅱ--R) and c-fms

采用Microgenie微机处理系统分析人胰岛素样生长因子Ⅱ(IGF-Ⅱ)、IGF-Ⅱ受体和C-fms癌基因cDNA的核苷酸顺序亲水性及空间结构,选择不同的氨基酸之间亲水性密集片断,经多肽合成仪以固相法进行全合成。用合成的三种基因多肽片断为抗原,分别免疫家兔制备成抗IGF-Ⅱ、IGF-Ⅱ受体和C-fms基因多肽产物抗体。采用免疫印迹法对3例配对的肝癌及癌旁肝组织进行初步应用研究,结果提示三种基因的异常过量表达与肝癌的发生关系密切。

Objective:To establish a method for monitoring of the gynecological malignancy patients with reservation of fertility and their children birthed after chemotherapy.Method:Using a semi_nested PCR SSCP technique to detect the FMS mutation in the patients and the controled group.Results:Among 4 specimens in study group,FMS mutation at codon 969 was found in a serum specimen from a patient with breast carcinoma ,treated with chemotherapy before her hysterectomy because of the diagnosis of leomyoma of the uterus...

Objective:To establish a method for monitoring of the gynecological malignancy patients with reservation of fertility and their children birthed after chemotherapy.Method:Using a semi_nested PCR SSCP technique to detect the FMS mutation in the patients and the controled group.Results:Among 4 specimens in study group,FMS mutation at codon 969 was found in a serum specimen from a patient with breast carcinoma ,treated with chemotherapy before her hysterectomy because of the diagnosis of leomyoma of the uterus .Interestingly ,wild type FMS gene was found in the leomyoma tissue of the same patients.Wild type FMS gene was also found in other 2 specimens of study group as well as in all specimens of control group.Conclusion:The mutation of FMS gene was found in serum specimen only,and the wild type of gene was found in the specimen obtained from the tissue of leomyoma from the same patient.This result implied that the mutation is acquired other than congenital,because the wild type gene was found in the body cells.According to the results of other researchers studies,the mutation should be caused by chemotherapy.Therefore,this study suggested that the detection of mutation of FMS gene may be used as a follow_up method for the patients with gynecologic malignancies cured by chemotherapy along and with reservation of fertility and their children born after the chemotherapy.However,the roll of the detection should be revaluated furthermore.

目的:探索一种可用于了解妇科肿瘤患者及其后代受化疗影响的检测方法。方法:以部分未经化疗的妇癌患者为对照, 对部分经化疗后痊愈的患者和后代用半巢式多聚酶链反应- 单链构象多态性分析法(Semi_nesled PCR_SSCP法) 检测FMS基因的突变。结果:实验组4 个标本中,1 个取自乳腺癌患者的血清标本的FMS969 密码子出现突变,其余3 个实验组的标本和对照组全部标本均为野生型FMS。结论:由于在1 例经过化疗的乳腺癌患者血清中检出FMS969 密码子突变,而其子宫肌瘤组织则为野生型,无突变。对照组无1 例突变。说明该患者FMS969 密码子的突变并非先天遗传的,而是后天的改变,因为在其体细胞上仍呈正常的基因型。根据有关研究结果推测,这种畸变很可能是化疗药物引起的。FMS基因突变的检测对化疗后保留生育力的患者及所生的子女的随访是有意义的,是一种可用于了解妇科肿瘤患者及其后代受化疗影响的检测方法

Objective To study the expressions of oncogenes c Ha ras, c ki ras, pan ras and c myc and point mutation of c Ha ras1 during hepatocarcinogenesis in rats. Methods Immunohistochemistry, in situ hybridization and microdissection of tissue (MDT) PCR SSCP were used to detect the oncogene expressions and point mutation of c Ha ras1 in both Solt Farber model and DEN induced liver cancer model. Results The overexpression of c Ha ras was closely associated with the formation and proliferation...

Objective To study the expressions of oncogenes c Ha ras, c ki ras, pan ras and c myc and point mutation of c Ha ras1 during hepatocarcinogenesis in rats. Methods Immunohistochemistry, in situ hybridization and microdissection of tissue (MDT) PCR SSCP were used to detect the oncogene expressions and point mutation of c Ha ras1 in both Solt Farber model and DEN induced liver cancer model. Results The overexpression of c Ha ras was closely associated with the formation and proliferation of the precancerous basophilic hepatocyte foci, while that of c myc with the growth of the oval cell foci. The abnormalities of IGF Ⅱ played an important role in the evolution of precancerous foci/nodules towards hepatocellular carcinoma (HCC). The overexpression of fms was only associated with HCC of some rats. Conclusion Hepatocarcinogenesis in rats was related with the overexpression of c Ha ras, c myc, IGF Ⅱand fms and the point mutation of c Ha ras1, and overexpression of these oncogenes was associated with morphological evolution.

目的 研究大鼠肝癌变过程中几种癌基因的表达和c Ha ras 1点突变。方法 通过DEN诱发癌变启动模型和肝癌模型 ,应用免疫组化、原位杂交和MDT PCR SSCP分别观测癌基因的表达和c Ha ras1点突变。结果 c Ha ras和c myc基因的过表达参与了肝癌变的全过程 ,其中c Ha ras的过表达与癌前嗜碱性肝细胞灶、c myc基因的过表达与卵圆细胞增殖关系密切。IGF Ⅱ基因的过表达对癌前肝细胞增生灶 /结节向肝细胞癌的演进起重要作用。fms基因过表达仅与个别大鼠肝细胞癌有关。结论 大鼠肝癌变过程与c Ha ras、c myc、IGF Ⅱ和fms基因的过表达及c Ha ras1点突变有关 ,并与形态演变相联系

 
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