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潜伏基因
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  latent gene
     Expression of EBV latent gene products and their significance in malignant lymphoma
     EBV潜伏基因产物在恶性淋巴瘤组织中的表达及意义
短句来源
     Purpose To study the expression and significance of EBV latent gene products in malignant lymphoma.
     目的 :探讨EBV潜伏基因产物在恶性淋巴瘤组织中的表达及意义。
短句来源
     Conclusion EBV infection may participate in the pathogenesis of partial SLE patients,the expression of EBV latent gene EBNA2 may be related to the pathogenesis of the autoimmune reaction of SLE.
     结论EBV感染参与部分SLE的发生发展,EBV潜伏基因EBNA2的表达可能诱发SLE患者的自身免疫反应。
短句来源
     LMP 1 expression was found in immunoblast cells and R S cells and R S like cells,which also expressed CD30. Conclusions Expression of EBV latent gene products can reflect the differential degree of host cells and ability of immune surveillance.
     T淋巴瘤EBV检出率 (2 3 8% )高于B淋巴瘤 (10 2 % )。 结论 :EBV潜伏基因产物表达情况能够反映出宿主细胞的分化程度和 (或 )宿主的免疫监视作用。
短句来源
  latent genes
     Objective To detect the expression of EBV latent genes in peripheral blood monocytes of EBV-positive SLE patients and to understand its clinical significance.
     目的检测EB病毒(EpsteinBarrvirus,EBV)潜伏基因在EBV阳性系统性红斑狼疮(systemiclupuserythematosus,SLE)患者外周血单一核细胞中的表达,探讨其临床意义。
短句来源
     Study on the Correlation Between the Expression of Epstein-Barr virus (EBV) Latent Genes and Systemic Lupus Erythematosus
     EB病毒潜伏基因表达与系统性红斑狼疮的关系
短句来源
  “潜伏基因”译为未确定词的双语例句
     Study on gene products of EBV infection in castric carcinoma patients
     胃癌患者EBV感染潜伏基因产物表达的研究
短句来源
     Methods The samples from 44 SLE patients and 43 matched normal controls were tested for EBV DNA BamHⅠ-W fragment by polymerase chain reaction(PCR)-Southern analysis . EBV nuclear antigen(EBNA)2, latent membrane protein(LMP)1 and 2A mRNA in EBV-positive samples of SLE patients were detected by RT-PCR and Southern blot.
     方法应用聚合酶链反应(PCR)Southern杂交技术检测44例SLE患者和43例正常对照者外周血单一核细胞中EBV特异性DNA片段BamHⅠW,筛选出EBV阳性标本,对EBV阳性标本进行RTPCR和Southern杂交,检测病毒潜伏基因(EBV核抗原基因EBNA2,潜伏膜蛋白基因LMP1和2A)的表达。
短句来源
     Objective:To investigate the expression of EBER1 and LMP1 in gastric carcinoma patients of EBV Infections.
     目的:研究EBV阳性胃癌中潜伏基因产物EBV编码的小RNA(EBER1)及潜伏膜蛋白LM P1的表达状况。
短句来源
     EBV does not usually replicate itself in B cells but establishes a latent infection instead.
     已知EB病毒在体外转化B淋巴细胞时至少表达10种潜伏基因
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  dormant genes
At least, in the camelids, HCAbs are not the result of resuscitation of dormant genes.
      
  latent gene
Some weak scattered signals, however, were seen in mRNA ISH for both lytic and latent gene transcription in all three tissue categories.
      
The aim of our study was to investigate a possible correlation between Epstein-Barr virus (EBV) infection status, including its latent gene expression, and expression of allergy-related genes in human tonsil-derived cells.
      
A key issue is whether the pattern of latent gene expression seen in the B cell is reflected in lung epithelial cells.
      
At present, it is unclear which latent gene products are responsible for immortalization.
      
By these criteria, EBV latent gene expression had prevented apoptosis induced by this genotoxin.
      
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  latent genes
EBV latent genes expression in all cultures were detected by mRNA in situ hybridization and immunofluorescence staining.
      
A 5-fold increase occurred in the LMP1-transfected cells, and a 10-fold increase was found in primary B cells transfected with both latent genes.
      
EBV can avoid the immunesystem by restricting expression of its latent genes.
      
However, the same treatment had no effect on transcription of cellular genes and KSHV latent genes.
      
Hence, an apparently normal strain may possess latent genes that have the potential to facilitate renal disease.
      
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Purpose To study the expression and significance of EBV latent gene products in malignant lymphoma. Methods Immunohistochemical staining for LMP 1 and EBNA2 was performed in 565 cases of non Hodgkins lymphoma(NHL) and 64 Hodgkins lymphoma(HL). EBV was also detected in 101 cases of NHL by PCR.Results EBV PCR positive rate was higher than that of LMP 1. LMP 1 expression was not found in EBV PCR negative NHL. No staining for EBNA2 was detected in our series. LMP 1 expression was found in immunoblast...

Purpose To study the expression and significance of EBV latent gene products in malignant lymphoma. Methods Immunohistochemical staining for LMP 1 and EBNA2 was performed in 565 cases of non Hodgkins lymphoma(NHL) and 64 Hodgkins lymphoma(HL). EBV was also detected in 101 cases of NHL by PCR.Results EBV PCR positive rate was higher than that of LMP 1. LMP 1 expression was not found in EBV PCR negative NHL. No staining for EBNA2 was detected in our series. LMP 1 expression was found in immunoblast cells and R S cells and R S like cells,which also expressed CD30. Conclusions Expression of EBV latent gene products can reflect the differential degree of host cells and ability of immune surveillance. EBV may be related to the development of some R S cells and R S like cells in malignant lymphomas.

目的 :探讨EBV潜伏基因产物在恶性淋巴瘤组织中的表达及意义。方法 :用免疫组化方法对 5 6 5例NHL、6 4例HL人体标本进行LMP 1、EBNA2对比检测 ,并选择 10 1例NHL进行PCR检测。结果 :EBV PCR检出率 (19 8% )高于LMP 1(14 9% ) ,PCR阴性病例LMP 1全部为阴性。EBNA2在全部病例均为阴性。在NHL和HL ,LMP 1阳性细胞主要是免疫母细胞样细胞、R S样细胞和R S细胞 ,LMP 1阳性的R S样细胞多数表达活化分子CD30。肠道原发恶性淋巴瘤EBV检出率较高 (2 3 1% )。T淋巴瘤EBV检出率 (2 3 8% )高于B淋巴瘤 (10 2 % )。结论 :EBV潜伏基因产物表达情况能够反映出宿主细胞的分化程度和 (或 )宿主的免疫监视作用。EBV在R S样细胞形成中可能起作用。EBV感染与肠道恶性淋巴瘤的发病有关

Objective To detect the expression of EBV latent genes in peripheral blood monocytes of EBV-positive SLE patients and to understand its clinical significance.Methods The samples from 44 SLE patients and 43 matched normal controls were tested for EBV DNA BamHⅠ-W fragment by polymerase chain reaction(PCR)-Southern analysis .EBV nuclear antigen(EBNA)2, latent membrane protein(LMP)1 and 2A mRNA in EBV-positive samples of SLE patients were detected by RT-PCR and Southern blot.Results In peripheral blood monocytes...

Objective To detect the expression of EBV latent genes in peripheral blood monocytes of EBV-positive SLE patients and to understand its clinical significance.Methods The samples from 44 SLE patients and 43 matched normal controls were tested for EBV DNA BamHⅠ-W fragment by polymerase chain reaction(PCR)-Southern analysis .EBV nuclear antigen(EBNA)2, latent membrane protein(LMP)1 and 2A mRNA in EBV-positive samples of SLE patients were detected by RT-PCR and Southern blot.Results In peripheral blood monocytes of the 44 SLE patients,32 were EBV DNA positive,while 3 were found in control group.The EBV DNA in SLE patients showed higher positive rate than that of the normal controls (χ~2=39.1779,P=0),but no difference was found in the subgroups of SLE patients(q=0.4025,P=0.7764).To 32 EBV-positive SLE patients,EBNA2 mRNA was detected in 20 of the cases,LMP1 mRNA was detected in 1 of the cases,but no LMP2A mRNA in all cases.Conclusion EBV infection may participate in the pathogenesis of partial SLE patients,the expression of EBV latent gene EBNA2 may be related to the pathogenesis of the autoimmune reaction of SLE.

目的检测EB病毒(EpsteinBarrvirus,EBV)潜伏基因在EBV阳性系统性红斑狼疮(systemiclupuserythematosus,SLE)患者外周血单一核细胞中的表达,探讨其临床意义。方法应用聚合酶链反应(PCR)Southern杂交技术检测44例SLE患者和43例正常对照者外周血单一核细胞中EBV特异性DNA片段BamHⅠW,筛选出EBV阳性标本,对EBV阳性标本进行RTPCR和Southern杂交,检测病毒潜伏基因(EBV核抗原基因EBNA2,潜伏膜蛋白基因LMP1和2A)的表达。结果44例SLE患者标本中有32例EBV阳性,正常对照组有3例EBV阳性,两组EBV阳性率比较差异有显著性(χ2=39.1779,P=0),SLE活动期和稳定期患者EBV阳性率比较差异无显著性(q=0.4025,P=0.7764)。32例EBV阳性SLE标本中有20例EBNA2mRNA阳性,1例LMP1mRNA阳性,但均未检测到LMP2AmRNA的表达。结论EBV感染参与部分SLE的发生发展,EBV潜伏基因EBNA2的表达可能诱发SLE患者的自身免疫反应。

Objective:To investigate the expression of EBER1 and LMP1 in gastric carcinoma patients of EBV Infections.Methods: EBER1 in 217 cases of gastric carcinoma was detected with In Situ Hybridization.Then,EBV positive cases were selected for analysis of the expression level of LMP1 by immunohistochemistry.Results: In 217 cases of gastric carcinoma,there were EBER1 positive 23 cases;The expressiones of LMP1 in EBV positive gastric carcinoma were not detected.Conclusions: There was no LMP1 expression in EBV positive...

Objective:To investigate the expression of EBER1 and LMP1 in gastric carcinoma patients of EBV Infections.Methods: EBER1 in 217 cases of gastric carcinoma was detected with In Situ Hybridization.Then,EBV positive cases were selected for analysis of the expression level of LMP1 by immunohistochemistry.Results: In 217 cases of gastric carcinoma,there were EBER1 positive 23 cases;The expressiones of LMP1 in EBV positive gastric carcinoma were not detected.Conclusions: There was no LMP1 expression in EBV positive Gastric carcinoma.

目的:研究EBV阳性胃癌中潜伏基因产物EBV编码的小RNA(EBER1)及潜伏膜蛋白LM P1的表达状况。方法:原位杂交法检测胃癌患者石蜡包埋组织标本中EBER1;免疫组化法检测EBV阳性胃癌中LM P1。结果:217例胃癌患者癌组织标本中检测到23例EBER 1;EBV阳性胃癌中无潜伏感染膜蛋白LM P1表达。结论:EBV阳性胃癌中缺乏潜伏感染膜蛋白LM P1的表达。

 
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