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疫苗
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  vaccine
    Immunogene Attenuates Hepatic Fibrosis with Vaccine Based on Xenogeneic CD40 Ligand
    异种CD154基因疫苗抗肝纤维化作用的研究
短句来源
    Immunological Observation of Attenuated Live Vaccine against Hepatitis A (H_2 Strain) in Children Aged 6-9 Years
    6~9岁儿童接种甲型肝炎减毒活疫苗(H_2株)的免疫效果观察
短句来源
    Antibody Response of Mice Orally Immunized with Live Attenuated Hepatitis A Vaccine(L-A-1 strain)
    甲型肝炎减毒活疫苗(L-A-1株)口服免疫小白鼠抗体反应
短句来源
    A study on immune efficacy in children immunized by hepatitis B vaccine in disease surveillance points of Fujian
    福建省疾病监测点儿童乙型肝炎疫苗免疫状况的调查
短句来源
    Experimental In Vivo Passage of H 2 Strain of Live Attenuated Vaccine of Hepatitis A in Common Marmosets
    甲型肝炎减毒活疫苗H_2株在狨猴体内传代的实验
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  vaccines
    Study on the Humoral Immune Response Induced by HBsAg Nucleic Acid Vaccines in H-2~b Mice
    HBsAg核酸疫苗诱导H-2~b小鼠体液免疫应答的初步研究
短句来源
    Application of mucosal vaccines in gut infections
    粘膜疫苗在胃肠道感染性疾病中的应用
短句来源
    Mr18 000、26 000 outer membrane proteins and HspA are outer membrane proteins of H. pylori, and the vaccines prepared with HspA was used to inoculate Balb/c mice, 70~80% of experimented mice were protected from H. pylori infection.
    而HspA和Mr为18 000、26 000的OMP为所有的H. pylori共同的抗原成分,以HspA为抗原的疫苗可使70%~80%试验小鼠获得保护。
短句来源
    In the group 1, 57 babies were inoculated with 20μg recombinant DNA vaccinia vaccines against hepatitis B. The injections were given at newborn, l month , and 6 months, respectively.
    I组:用痘苗重组DNA乙肝疫苗57例,在婴儿娩出后1个月、6月龄进行注射,每次20ug。
短句来源
    In group 3, 44 newborn babies were inoculated with 10μg as same vaccines as group 2 HBIG plus 1ml(200 U/ml),at same time intervals as group l.
    III组:疫苗来源同I组,出生时同时给以乙肝免疫球蛋白(HBIG)1支,含量为200U/ml,每次lml,臂部肌内注射,1、6月龄重复注射上述疫苗10ug。
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  “疫苗”译为未确定词的双语例句
    The Ckanges of Inttrleukin-2 Level and T Cell Subsets in Peripheral Blood of Patients with
    麻疹减毒活疫苗治疗慢性活动性肝炎外周血IL-2和T细胞亚群的变化
短句来源
    A preliminary study on the mechanism and prognosis of immune failure of vaccination against HBV in intrauterine HBV infected infants
    宫内感染HBV婴儿接种乙肝疫苗免疫失败的机理和预后研究
短句来源
    Results The incidence rate of hepatitis B in Quzhou in 2005 was 43.14/lakh, while the inoculation rate of hepatitis B was above 95% among children. The HBsAg positive rate was averagely 3.21% among the crowd, and anti-HBsAg positive rate 43.38%, averagely.
    结果2005年衢州市乙肝发病率43.14/10万,儿童乙肝疫苗报告接种率在95%以上,衢州市人群的HBsAg阳性率平均为3.21%,抗-HBs阳性率平均为43.38%。
短句来源
    After injected HBVV and HIGB, HBsAb positive ratio of HBV-DNA positive group in both umbilical blood serum and UBMC was lower than that of only umbilical blood serum positive group when infants were 1 years old (50.00% vs 77.78%,P<0.05). And they were lower than that of HBV-DNA negative group in both umbilical blood serum and UBMC (96.67%,P<0.05).
    正规注射HBIG和乙肝疫苗后,新生儿脐血清和UBMC中HBV-DNA同时阳性组婴儿1岁时HBsAb阳转率明显低于血清HBV-DNA阳性、UBMC阴性组(50·00%vs·77·78%,P<0·05),二者都低于HBV-DNA阴性婴儿组(96·67%,P<0·05)。
短句来源
    HBV genotypes were determined by type-specific primers PCR method. PreC/BCP mutations were detected by direct sequencing of PCR products,and Clustal W 1.8 software was applied to analyzing the sequences.
    以型特异性引物PCR法检测16对乙肝疫苗阻断失败的母婴和88例阻断成功的母亲血清样本中HBV基因型,用PCR产物直接测序法检测HBV前C/ BCP突变,采用Clustal W 1.8软件进行序列分析。
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  vaccine
TRANSFERSOMES FOR VACCINE DELIVERY: A POTENTIAL APPROACH FOR TOPICAL IMMUNIZATION
      
Delivery of vaccine is a major impediment to ensuring vaccine efficacy and compliance.
      
Existing vaccine delivery approaches have their limitations and these led to the development of novel approaches for vaccine delivery.
      
Non-invasive vaccine delivery is in demand and for this skin appears to be a potential sites that elicit immune responses.
      
This approach may present a general strategy for eliciting immune responses with DNA vaccine delivered by live bacterial vectors.
      
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  vaccines
It has potential to reduce physical skin penetration by injection and provide potentially effective vaccines.
      
Pseudorabies virus (PRV), an alpha-herpesvirus, has been developed as a live viral vector for animal vaccines.
      
Thus, the development of the new PRV recombinant expressing the modified GP5m protein as a candidate vaccine established the basis for the study of bivalent genetic engineering vaccines against PRRSV and PRV.
      
However, reports about screening the effective antigen and research on vaccines of V.
      
These results indicate that the 43 kDa and 52 kDa flagellin and OMP of size 43 kDa, 52 kDa can be candidates for developing vaccines against V.
      
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Infants of mothers sero-positive for HBsAg and HBeAg were given three doses of 20μg hepatitis B(HB) vaccine at birth, at one and six months of age respectively.These babies were followed up 2years.64 babies with vaccine success and 29 with vaccine failure were randomly selected.Dot-hybridization was carried out to detect HBV-DNA levels in the sera of mothers at delivery.Results showed that maternal HBV-DNA level in the group with vaccine failure was significantly higher than that of the group with vaccine success,showing...

Infants of mothers sero-positive for HBsAg and HBeAg were given three doses of 20μg hepatitis B(HB) vaccine at birth, at one and six months of age respectively.These babies were followed up 2years.64 babies with vaccine success and 29 with vaccine failure were randomly selected.Dot-hybridization was carried out to detect HBV-DNA levels in the sera of mothers at delivery.Results showed that maternal HBV-DNA level in the group with vaccine failure was significantly higher than that of the group with vaccine success,showing that high maternal HBV-DNA level is one of important factors associated with the vaccine failure.This study has provided a basis for promotion of vaccine effcacy in prevention of mother-to-infant transmission of hepatitis B virus.

血清HBsAg、HBeAg双阳性母亲的新生儿分别于出生时、1月龄、6月龄各接种1剂20μg乙型肝炎(乙肝)疫苗后随访2a。随机抽取母婴乙肝病毒(HBV)传播阻断成功的64例、失败的29例。用斑点杂交测定孕妇临产时血清HBV-DNA水平。结果表明疫苗阻断母婴传播成功组孕妇血清HBV-DNA水平明显低于失败组提示孕妇血清HBV-DNA水平高可能是疫苗阻断母婴传播失败原因之一。

ne hundred and six neonates born to HBeAg-Positive and HBsAg-Carrier motherswere randomly divided into two groups,In one group each infant received 20 μg perdose of yeast derived recombinant hepatitis B vaccine (recombinant vaccine)and eachinfant in the other group received 20 μg per dose of plasma derived hepatitis B vac-cine(plasma vaccine)on the day of birth,at 1 month and at 6 Inonths (three times). Physical examination and blood testing were performed for all infants at 6,12,24,36, and 48 months of age....

ne hundred and six neonates born to HBeAg-Positive and HBsAg-Carrier motherswere randomly divided into two groups,In one group each infant received 20 μg perdose of yeast derived recombinant hepatitis B vaccine (recombinant vaccine)and eachinfant in the other group received 20 μg per dose of plasma derived hepatitis B vac-cine(plasma vaccine)on the day of birth,at 1 month and at 6 Inonths (three times). Physical examination and blood testing were performed for all infants at 6,12,24,36, and 48 months of age. The results showed that the protective efficacy rates at 6,12,24,36,and 48 monthswere 66.7%,75.0% , 62.5%, 61.7% and 56.5% respectively for the recombinantvaccine group,and 57.7%, 75.5%, 51.1%, 40.5% and 23.8% respectively for plasmavaccine group.The differences of protective efficacy rates between the two groups werenot statistically significant by Chi-square test in the first two years,and were muchmore significant in the last two years. The study indicates that for the prevention of mother-infant transmission of hepa- titis B virus the protective efficacy of the recombinant vaccine and of the plasma va-ccine are approximate in the near future, and the long term efficacy of the recombinantvaccine is longer than that of the plasma vaccine.

已知血源乙型肝炎疫苗(简称血源疫苗)能有效地阻断乙型肝炎传播,个体接种后的免疫效果可持续至少3年。我们对血清HBeAg阳性和HBsAg携带者母亲分娩的106名新生儿随机分为二组,分别接受美国提供的由酵母菌提取的重组乙型肝炎基因疫苗(简称重组疫苗)和国产血源疫苗,以等剂量和同样的免疫顺序,作对照试验,分析二者对阻断母婴传播的长期效果。以保护性抗体的滴度≥10mIU/ml的持续存在分析保护效果,指出重组疫苗使用安全无明显副反应;近期的保护效果与血源疫苗相似,而远期效果比血源疫苗长。

Experiment was conducted to determine the immunological effect of attenuated lice vaccine against hepatitis A (H2 strain) in 138 children with anti-HAVIg. anti-HAVIgM. HBsAg and SGPT being negative or within normal range. without a contact history of hepatitis A and a allergic history, aged 6-9 years. one hundred and fourteen of subjects were allocated to a experimental group and 24 to a control group. The results showed that positivity rate of total HAV antibodies were 81. 81% and 96. 08% after 2 and 4 wks...

Experiment was conducted to determine the immunological effect of attenuated lice vaccine against hepatitis A (H2 strain) in 138 children with anti-HAVIg. anti-HAVIgM. HBsAg and SGPT being negative or within normal range. without a contact history of hepatitis A and a allergic history, aged 6-9 years. one hundred and fourteen of subjects were allocated to a experimental group and 24 to a control group. The results showed that positivity rate of total HAV antibodies were 81. 81% and 96. 08% after 2 and 4 wks of vaccination, respectively, and there was significant difference between two groups (P<0. 01). Nobody showed fever and clinical symptoms of hepatitis A. only 5. 06% of subjects had areolae 0. 2-0. 5 centimetre in diameter.There was no significant differencde between experimental and control groups in SGPT level (P>0. 05). It was proved that the vaccine is safe and effective.

我们选择抗-HAVIgG、抗-HAVIgM、HBsAg、SGPT等指标阴性,无甲肝接触史,无过敏史的6~9岁儿童114人作为免疫对象,24人作为对照组,进行甲肝减毒活疫苗(H2株)的免疫效果观察。结果甲肝总抗体阳转率免疫2周为81.81%,4周为96.08%,免疫组与对照组差异非常显著(P<0.01);接种疫苗后24h、48h、72h作体温、全身及局部反应视察,未发现有体温升高和甲肝临床症状者,局部无红肿疼痛,仅有5.06%的人局部出现直径为02-0.5cm的红晕;免疫组与对照组的SGPT无显著差异(P>0.05)。提示此疫苗安全有效,具有较高的应用价值。

 
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