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阴茎海绵体
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  corpus cavernosum
    Effect of Icariin on the mRNA and protein expression of NOS isoform in corpus cavernosum of castrated rats
    淫羊藿苷对去势大鼠阴茎海绵体一氧化氮合酶亚型mRNA和蛋白表达的影响
短句来源
    Modulation action of berberine on NO-cGMP signal pathway in isolated corpus cavernosum smooth muscle
    小檗碱对离体阴茎海绵体NO-cGMP信号通路的调控
短句来源
    Results ①Ber,sildenafil (Sild),papaverine (Pap) and amrinone (Amr) could concentration-dependently relax the smooth muscle of corpus cavernosum and the rank order of potency was: Sild>Ber>Pap>Amr. Their EC_ 50 was 0.84,6.20,15.00 and 27.69 μmol/L respectively.
    结果 在离体兔阴茎海绵体平滑肌标本上①Ber、西地那非(sildenafil, Sild)、罂粟碱(papaverine, Pap) 及氨力农(amrinone, Amr) 均可浓度依赖性地引起舒张效应, 其作用强度依次为Sild>Ber>Pap>Amr, EC50分别为0 .84, 6 .20, 15. 00 和27. 69μmol/L。
短句来源
    Relaxant Effects of Icariin on the Rabbit Corpus Cavernosum and Its Mechanism
    淫羊藿苷对家兔阴茎海绵体的舒张作用及机制
短句来源
    Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arteriogenic erectile dysfunction rat model
    淫羊藿苷对动脉性ED模型大鼠阴茎海绵体压力和一氧化氮合酶亚型表达的影响
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  corpora cavernosa of penis
    Results The sexual activities in the model group degraded(P<0.01),and the contents of smooth muscle in the Corpora Cavernosa of penis and eNOS also degraded(P<0.05 and 0.01),and the collagen step up(P<0.05).
    结果模型组大鼠性活动降低(P<0.01),阴茎海绵体平滑肌含量及eNOS含量均降低(P<0.05和0.01),而胶原含量升高(P<0.05);
短句来源
    10 days later,the sexual activities were observed,and the partial Corpora Cavernosa of penis was removed to be observed for the contents of the smooth muscle,collagen,blood sinusoid after Masson's stain. Immunohistochemistry in combination with image analysis system was used to detect the contents of endothelium nitric oxide synthase(eNOS) in Corpora Cavernosa of penis.
    造模并给药10 d后观察其性活动,并取大鼠阴茎海绵体组织经Masson’s染色后观察海绵体组织中平滑肌、胶原、血窦腔隙含量,应用免疫组化法结合图像分析系统检测实验各组阴茎海绵体组织内皮型一氧化氮合酶(eNOS)含量。
短句来源
  cavernosum
    Effect of Icariin on the mRNA and protein expression of NOS isoform in corpus cavernosum of castrated rats
    淫羊藿苷对去势大鼠阴茎海绵体一氧化氮合酶亚型mRNA和蛋白表达的影响
短句来源
    Modulation action of berberine on NO-cGMP signal pathway in isolated corpus cavernosum smooth muscle
    小檗碱对离体阴茎海绵体NO-cGMP信号通路的调控
短句来源
    Results ①Ber,sildenafil (Sild),papaverine (Pap) and amrinone (Amr) could concentration-dependently relax the smooth muscle of corpus cavernosum and the rank order of potency was: Sild>Ber>Pap>Amr. Their EC_ 50 was 0.84,6.20,15.00 and 27.69 μmol/L respectively.
    结果 在离体兔阴茎海绵体平滑肌标本上①Ber、西地那非(sildenafil, Sild)、罂粟碱(papaverine, Pap) 及氨力农(amrinone, Amr) 均可浓度依赖性地引起舒张效应, 其作用强度依次为Sild>Ber>Pap>Amr, EC50分别为0 .84, 6 .20, 15. 00 和27. 69μmol/L。
短句来源
    Effect of Icarrin on cGMP levels in penile corous cavernosum of rabbit
    淫羊藿苷对家兔阴茎海绵体cGMP浓度的效果
短句来源
    Relaxant Effects of Icariin on the Rabbit Corpus Cavernosum and Its Mechanism
    淫羊藿苷对家兔阴茎海绵体的舒张作用及机制
短句来源
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  “阴茎海绵体”译为未确定词的双语例句
    Methods In the in vitro cultured corpus cavernsum smooth muscles of 3rd to 4th in New Zealand rabbits,[Ca~(2+)] i was measured by fluorescence ion digital Imaging system (FIDIS),using Fluo-2/AM as a Ca~(2+)-sensitive fluorescenct indicator.
    方法体外培养的第3~4代新西兰白兔阴茎海绵体平滑肌细胞,经钙荧光指示剂Fluo-2/AM负载后,用荧光离子数字成像系统观察Tet对平滑肌细胞内[Ca~(2+)]i的影响。
短句来源
    Compared with the model group,the sexual activities were improved obviously in the Yikan capsule high dose and middle dose group,and the contents of smooth muscle and eNOS step up too(P<0.01),and the collagen degraded(P<0.01).
    与模型组相比,益坎胶囊高、中剂量组大鼠性活动能力明显改善(P均<0.01),阴茎海绵体平滑肌含量及eNOS含量均增高(P<0.01),而胶原含量降低(P<0.01)。
短句来源
    Effects of Telramethylpyraze on Cytosolic Free Calcium Concentration in Penis Corpus Cavernsum Smooth Muscle Cells in Rabbits
    川芎嗪对家兔阴茎海绵体平滑肌细胞游离钙浓度的影响
短句来源
    Part three: After 4 weeks oral treatment with icariin (5mg/kg/day and 10mg/kg/day) for A-ED rats, the ICP was measured and the expression of nNOS, iNOS and eNOS in RCC was investigated by RT-PCR, Western-blot analyses. NOS activities of different group were also checked with NOS kit.
    第三部分:给A-ED模型大鼠随机分4组,灌服不同剂量的淫羊藿苷(5mg,10mg/kg),4周后观察ICP的变化,采用RT-PCR、Western blot方法观察术后3d、7d、14d和28d阴茎海绵体内NOS亚型的表达变化,检测NOS活性改变,探讨淫羊藿苷对A-ED模型勃起功能的效果及作用机制。
短句来源
    EC 50 of Icariin was 5 13 μmol·L -1 (while EC 50 of sildenafil and papaverine was: 0 31 μmol·L -1 and 3 15 μmol·L -1 ) respectirely.
    结果 淫羊藿苷能提高阴茎海绵体内cGMP浓度 ,具有浓度依赖性 (P<0 0 0 1) ,其半数有效浓度 (EC50 )为 5 13μmol·L-1,而西地那非 0 31为 μmol·L-1,罂素碱为 3 15 μmol·L-1。
短句来源
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  corpus cavernosum
Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).
      
Moreover, there is a potential risk of damage to the corpus cavernosum.
      
Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.
      
Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.
      
Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.
      
更多          
  cavernosum
Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).
      
Moreover, there is a potential risk of damage to the corpus cavernosum.
      
Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.
      
Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.
      
Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.
      
更多          


AIM To study the effect of ginsenoside Rb 1 on mouse sexual function and its mechanism. METHODS Male mice were treated with Rb 1(2 5, 5 0 and 10 0 mg·kg -1 , ip) for three weeks, their sexual behaviors(mounting, mating) were assessed every day. After final treatment, plasma testosterone and cGMP and NO concentration in mice corpus cavernosum were measured by radioimmunoassy and spectrophotometry; Rabbit corpus cavernosum (RCC) segments were incubated with Rb 1(0 05, 0 5 and 5 μmol·L -1...

AIM To study the effect of ginsenoside Rb 1 on mouse sexual function and its mechanism. METHODS Male mice were treated with Rb 1(2 5, 5 0 and 10 0 mg·kg -1 , ip) for three weeks, their sexual behaviors(mounting, mating) were assessed every day. After final treatment, plasma testosterone and cGMP and NO concentration in mice corpus cavernosum were measured by radioimmunoassy and spectrophotometry; Rabbit corpus cavernosum (RCC) segments were incubated with Rb 1(0 05, 0 5 and 5 μmol·L -1 ). The formation of cGMP was stimulated with 10 μmol·L -1 sodium nitroprusside(SNP), and the cGMP level was measured as above. RESULTS Rb 1(5 0, 10 0 mg·kg -1 ) significantly increased the mounting and mating numbers and serum testosterone level in vivo . The cGMP and NO concentration in MCC were dose dependently increased after 3 weeks treatment. Rb 1(0 05, 0 5, 5 μmol·L -1 ) was shown to dose dependently enhance the cGMP level in incubated RCC in the presence of SNP 10 μmol·L -1 . CONCLUSION These results demonstrate that Rb 1 improved the sexual behavior of mice and this effect could be attributed to its action of increasing plasma testosterone level and the activation of NO/cGMP pathway.

目的 研究人参皂苷Rb1对小鼠性功能的影响及其作用机制。方法 小鼠ipRb1,每天进行性行为检测 ,3周后 ,测定小鼠血清睾酮浓度、阴茎海绵体组织 (MCC)cGMP及NO水平 ;离体温孵破坏内皮组织的兔海绵体组织 (RCC) ,检测在NO供体硝普钠 (SNP)存在下 ,Rb1对RCC中cGMP水平的影响。结果 Rb15 0 ,10 0mg·kg-1给药后d 14及d 16 ,小鼠跨骑和交配次数显著增加 ,血清睾酮浓度、MCC中cGMP及NO水平提高 ;Rb10 0 5 ,0 5 0 ,5 0 0 μmol·L-1可明显提高离体RCCcGMP浓度。结论 Rb1可显著改善小鼠性功能 ,其作用机制可能通过提高雄激素水平、激活NO/cGMP通路而起作用

Objective:To inverstigate the effection of penis erection after injecting compound salviol miltirone (CSM). Methods:18 dogs were injected with different drugs, the introcorporeal pressure (ICP) and distention time (DT) were measured, the doses of papaverine in different groups were compared. Results:The result showed that there weren't penis sufficient using CSM only. but penis was successfully erected by injecting CSM, the doses of papaverine were significantly decreased in this process.Conclusion:CSM which...

Objective:To inverstigate the effection of penis erection after injecting compound salviol miltirone (CSM). Methods:18 dogs were injected with different drugs, the introcorporeal pressure (ICP) and distention time (DT) were measured, the doses of papaverine in different groups were compared. Results:The result showed that there weren't penis sufficient using CSM only. but penis was successfully erected by injecting CSM, the doses of papaverine were significantly decreased in this process.Conclusion:CSM which was made of papaverine. phentolamine and salviol miltirone is better than others.

目的 :观察阴茎海绵体内注射丹参混合液诱发阴茎勃起的效应。方法 :选择 18条雄性杂狗 ,分别观察不同药物阴茎海绵体注射后的海绵体内压 (ICP)的变化、阴茎膨胀维持时间 (DT)的长短 ,比较了各组罂粟碱的剂量大小。结果 :(1)单用丹参不能诱发成功勃起 ;(2 )丹参混合液能成功诱发阴茎勃起且可显著降低罂粟碱的剂量 ,而且单纯在罂粟碱中加入丹参或酚妥拉明并不能减少罂粟碱的用量。结论 :丹参混合液是一种配方合理、副作用少且能阴茎海绵体直接注射的药物。

AIM To investigate the effect of Icarrin on penile erection and cyclic GMP levels in rabbit corpus cavernosum(RCC). METHODS Effects of various concentration of Icariin on cGMP level in RCC were measured by 125 I radioimmunoassay procedure with Sildenafil and papaverine as the positive controls RESULTS In the presence of SNP, Icariin increased cGMP concentration in rabbit corpus cavernosum in a dose dependent manner ( P <0 01). EC 50 of Icariin was 5 13 μmol·L -1 (while EC 50...

AIM To investigate the effect of Icarrin on penile erection and cyclic GMP levels in rabbit corpus cavernosum(RCC). METHODS Effects of various concentration of Icariin on cGMP level in RCC were measured by 125 I radioimmunoassay procedure with Sildenafil and papaverine as the positive controls RESULTS In the presence of SNP, Icariin increased cGMP concentration in rabbit corpus cavernosum in a dose dependent manner ( P <0 01). EC 50 of Icariin was 5 13 μmol·L -1 (while EC 50 of sildenafil and papaverine was: 0 31 μmol·L -1 and 3 15 μmol·L -1 ) respectirely. CONCLUSIONS The effect of Icariin on penile erection may be mediated by increasing cGMP levels in CC for enhancing the relaxation response of CC.

目的 观察淫羊藿苷对家兔阴茎海绵体组织中cGMP浓度的影响。方法 应用12 5I放射免疫法 ,测定不同浓度的淫羊藿苷对阴茎海绵体内PDE5酶底物cGMP浓度的影响 ,并以西地那非和罂粟碱作为阳性对照。结果 淫羊藿苷能提高阴茎海绵体内cGMP浓度 ,具有浓度依赖性 (P<0 0 0 1) ,其半数有效浓度 (EC50 )为 5 13μmol·L-1,而西地那非 0 31为 μmol·L-1,罂素碱为 3 15 μmol·L-1。结论 淫羊藿苷对阴茎勃起的作用机制与其能提高海绵体平滑肌cGMP浓度而增强阴茎海绵体平滑肌松弛作用有关

 
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