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阴茎海绵体
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  corpus cavernosum
    Objective:To investigate the mechanism of diabetic erectile dysfunction(ED) by detecting the variation of the activity and distribution of nuclear factor-kappaB(NF-κB) in the corpus cavernosum of rats with diabetes mellitus.
    目的:观察糖尿病雄性SD大鼠阴茎海绵体组织中核因子-κB(NF-κB)活性的变化以及分布,探讨糖尿病性勃起功能障碍(ED)发病机制。
短句来源
    The nNOS-containing Nerve Fibers Changes in Corpus Cavernosum of Diabetic Rat
    糖尿病大鼠阴茎海绵体组织nNOS神经变化的实验研究
短句来源
    The Alteration of eNOS and iNOS Expression in Corpus Cavernosum of Hyperlipidemia Rats
    高脂血症大鼠阴茎海绵体组织eNOS/iNOS蛋白表达变化的实验研究
短句来源
    Methods 105 cases of diabetic ED were randomly divided into group Ⅰ(control group),group Ⅱ( injecting prostaglandin E 1 into corpus cavernosum of penis) and group Ⅲ(taking mecobalamin,cilostazol and testosterone undecanoate orally).
    方法 将 10 5例糖尿病性ED患者随机分为Ⅰ组 (对照组 )、Ⅱ组 (前列腺素E1阴茎海绵体注射治疗组 )、Ⅲ组 (甲钴胺、西洛他唑和十一酸睾酮口服治疗组 )。
短句来源
    Objective: To investigate the effects of hyperlipidemia on eNOS and iNOS in corpus cavernosum of ratsMethods: Twenty-eight male SD rats were divided randomly into two groups ,experiment group and control group .
    目的:探讨高脂血症对大鼠阴茎海绵体组织内皮型一氧化氮合酶(eNOS)和诱生型一氧化氮合酶(iNOS)蛋白表达的影响。
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  cavernosum
    After eight weeks each rat cavernosum tissue was harvested and homogenated to detect the content of AGE-peptide(AGE-P),NO and the activity of NOS.
    饲养8周后取各组大鼠阴茎海绵体组织,匀浆后检测AGE-肽(AGE-P)含量、NO含量及各型NOS酶活性.
短句来源
    Compared with CONTROL group,the content of AGE-P,NO and the activity of inducible nitric oxide synthase(iNOS)in rat cavernosum tissue were significantly high in DM group(P<0.05),but the activity of constitutive nitric oxide synthase(cNOS)were significantly low in DM group(P<0.05); The administration of AG to DM rats reversed the above results;
    DM组阴茎海绵体组织中AGE-P含量、NO含量及诱导型NOS(iNOS)活性明显高于CONTROL组(P<0.05),而结构型NOS(cNOS)活性则明显低于后者(P<0.05),而AG则明显减少了DM大鼠阴茎海绵体组织中AGE-P、NO的生成和减弱了iNOS活性,增强了cNOS活性;
短句来源
    Objective:To investigate the mechanism of diabetic erectile dysfunction(ED) by detecting the variation of the activity and distribution of nuclear factor-kappaB(NF-κB) in the corpus cavernosum of rats with diabetes mellitus.
    目的:观察糖尿病雄性SD大鼠阴茎海绵体组织中核因子-κB(NF-κB)活性的变化以及分布,探讨糖尿病性勃起功能障碍(ED)发病机制。
短句来源
    The nNOS-containing Nerve Fibers Changes in Corpus Cavernosum of Diabetic Rat
    糖尿病大鼠阴茎海绵体组织nNOS神经变化的实验研究
短句来源
    The Alteration of eNOS and iNOS Expression in Corpus Cavernosum of Hyperlipidemia Rats
    高脂血症大鼠阴茎海绵体组织eNOS/iNOS蛋白表达变化的实验研究
短句来源
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  “阴茎海绵体”译为未确定词的双语例句
    Clinical analysis of intracavernosal self injection of prostaglandin E_1 in erectile dysfunction of 30 cases of diabetic patients
    阴茎海绵体自行注射前列腺素E_1治疗30例糖尿病性阳萎疗效分析
短句来源
    Study of free-radical metabolization of corpora cavernsum penis tissues in experimental diabetic rats
    实验性糖尿病大鼠阴茎海绵体组织自由基代谢的研究
短句来源
    Apoptosis and the Expression of Bax and Bcl-2 in the Penis of Diabetic Rats
    糖尿病大鼠阴茎海绵体细胞凋亡与Bcl-2和Bax基因表达
短句来源
    Study of transcription factor nuclear factor-κB in cavernous tissue of rat models of diabetes mellitus
    糖尿病大鼠阴茎海绵体组织中核因子κB表达的研究
短句来源
    Conclusion Intracavernosal self injection of prostaglandin E 1 is a effective therapeutic method.
    结论 阴茎海绵体内自行前列腺素 E1 注射是一项有效的治疗糖尿病性勃起功能障碍的可供选择的治疗方法。
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  corpus cavernosum
Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).
      
Moreover, there is a potential risk of damage to the corpus cavernosum.
      
Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.
      
Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.
      
Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.
      
更多          
  cavernosum
Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).
      
Moreover, there is a potential risk of damage to the corpus cavernosum.
      
Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.
      
Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.
      
Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.
      
更多          


Objective To evaluate the effect and ability of intracavernosal self injection of prostaglandin E 1 on erectile dysfunction of diabetic patients.Methods 30 cases of erectile dysfunction with diabetic patients were studied.Results The doses of prostaglandin electing effective erection were 15μg in 2 cases,20μg in 22 cases,25μg in 1 case,30μg in 2 cases,40μg in 1 case.2 cases were effectless for 40μg of prostaglandin E 1. Time of erection were 24~106 min (50 7±19 5min). Side effects from self injection...

Objective To evaluate the effect and ability of intracavernosal self injection of prostaglandin E 1 on erectile dysfunction of diabetic patients.Methods 30 cases of erectile dysfunction with diabetic patients were studied.Results The doses of prostaglandin electing effective erection were 15μg in 2 cases,20μg in 22 cases,25μg in 1 case,30μg in 2 cases,40μg in 1 case.2 cases were effectless for 40μg of prostaglandin E 1. Time of erection were 24~106 min (50 7±19 5min). Side effects from self injection of prostaglandin E 1: local mild pain on injection were in 6 cases, small local bleed in 3 cases, no case causing priajpism, comfortless of erection in 6 cases.Conclusion Intracavernosal self injection of prostaglandin E 1 is a effective therapeutic method.

目的 观察阴茎海绵体自行注射前列腺素 E1 治疗糖尿病性阳萎的疗效。方法 对 30例合并有勃起功能障碍的糖尿病病人 ,在医生指导下施行自行阴茎海绵体内注射前列腺素 E1 。结果 病人勃起所需适宜剂量为 :15 μg2例 ,2 0μg 2 2例 ,2 5μg 1例 ,30μg 2例 ,40μg 1例 ,2例注射 40μg无有效勃起。勃起持续时间为 2 4~ 10 6分钟 (5 0 .7± 19.5分钟 )。不良反应有局部轻度疼痛和不适 6例 ,局部少量出血 3例 ,未发生阴茎长时间持续勃起。结论 阴茎海绵体内自行前列腺素 E1 注射是一项有效的治疗糖尿病性勃起功能障碍的可供选择的治疗方法。

Objective: To study change of free radical of corpora cavernosum peni tissues in experimental diabetic rats.Methods: SOD activities and MDA were determined by xanthionxid methol and barbital acid microdermination. Results: SOD activities in corproa cavernosum penis tissues of diabetic rats were lower than those of the control.MDA level was markedly higher than that of the control. Conclusions: Free radical metabelization in diabetic rats shows disturbance, which may play a role in the development of diabetic...

Objective: To study change of free radical of corpora cavernosum peni tissues in experimental diabetic rats.Methods: SOD activities and MDA were determined by xanthionxid methol and barbital acid microdermination. Results: SOD activities in corproa cavernosum penis tissues of diabetic rats were lower than those of the control.MDA level was markedly higher than that of the control. Conclusions: Free radical metabelization in diabetic rats shows disturbance, which may play a role in the development of diabetic impotence.

目的:通过体内实验,探讨实验性糖尿病大鼠阴茎海绵体组织自由基变化。方法:采用黄嘌呤氧化法测定超氧化物岐化酶(SOD)活性,用改良巴比妥酸微量法测定丙二醛(MDA)含量。结果:糖尿病大鼠阴茎海绵体组织SOD明显低于对照组(P<0.01),MDA明显升高(P<0.001)。结论:在本实验条件下,实验性糖尿病大鼠阴茎海绵体组织自由基代谢明显障碍,这种变化可能在糖尿病患者阳痿的发生发展中起一定作用。

Objectives: To investigate the effect of diabetes mellitus on nNOS containing nerve fibers in rats corpus cavernosum. Methods: Healthy male Sprague Deuley rats ( n =34) were divided into two groups randomly, the sixth ( n =17) and eighth groups ( n =17). Eleven of severteen rats wree intraperitoneal injection with streptozotocin (STZ)to induce experimented model of diabetes meditus in each group. The other were injected with citrate buffer as control. Injected with apmorphine at sixth and eight week,penile...

Objectives: To investigate the effect of diabetes mellitus on nNOS containing nerve fibers in rats corpus cavernosum. Methods: Healthy male Sprague Deuley rats ( n =34) were divided into two groups randomly, the sixth ( n =17) and eighth groups ( n =17). Eleven of severteen rats wree intraperitoneal injection with streptozotocin (STZ)to induce experimented model of diabetes meditus in each group. The other were injected with citrate buffer as control. Injected with apmorphine at sixth and eight week,penile erection in diabetic and control groups were observed and noted. The expression of nNOS positive containing nerver fibers in corpous cavernosum were examined with streptavidin peroxidase immunohistochemistry (SP method). Results: The erection rate of penile diabetic mellitus decreased compared to that in controls ( P <0.01). The erection rate of two diabetic groups were 37.5% and 14.3%,respectively, with significant difference ( P <0.05).The controls were all 100%. The sigificiant changes of nNOS containing never fibers were observed in the two diabetic groups. The numbers of nNOS containing nerver fibers in the corpus cavernosum in the two diabetic groups were (37.00±6.76) and (28.00±5.29),respectively, with significant difference compared to each other ( P <0.05). In the two controls, the fibers were (83.00±3.22) and (81.00±3.61),respectively. The fibers in diabetic groups were less than those in controls( P < 0.01 ). Conclusions: The erectile function of rats and the number of nNOS positive containing nerve fibers is affected seriously by diabetes mellitus and it is positively correlated to the duration of diabetes mellitus.The decreasing of nNOS positive containing nerve fibers may be one of the mechanisms of diabetic erectile dysfunction.

目的 :研究糖尿病对大鼠阴茎海绵体组织nNOS神经纤维的影响。 方法 :34只SD雄性大鼠分为 6周组(17只 )和 8周组 (17只 ) ,其中每组各 11只腹腔注射链脲佐菌素制备糖尿病模型 ,其余各 6只注射柠檬酸缓冲液作为空白对照 ,分别在注射 6周和 8周后 ,观察大鼠阴茎勃起功能 ,并采用免疫组化SP法检测糖尿病大鼠阴茎组织nNOS神经纤维的数量。 结果 :2组糖尿病大鼠的阴茎勃起率分别为 37.5 %和 14 .3% ,差异有显著性 (P <0 .0 5 ) ,均明显低于对照组 (P <0 .0 1)。 2组糖尿病大鼠nNOS神经纤维的表达明显低于对照组 (P <0 .0 1)。 8周组中糖尿病大鼠阴茎的勃起功能和nNOS神经纤维的数量明显低于 6周组 ,分别为 (37.6 0± 6 .76 )条和 (2 8.0 0±5 .2 9)条 ,即随着病程的延长 ,勃起功能和nNOS神经纤维的表达下降 (P <0 .0 5 ) ,而对照组大鼠nNOS神经纤维的数量差异无显著性 [(83.0 0± 3.2 2 )vs(81.0 0± 3.6 1) ]。 结论 :糖尿病严重影响勃起功能和nNOS神...

目的 :研究糖尿病对大鼠阴茎海绵体组织nNOS神经纤维的影响。 方法 :34只SD雄性大鼠分为 6周组(17只 )和 8周组 (17只 ) ,其中每组各 11只腹腔注射链脲佐菌素制备糖尿病模型 ,其余各 6只注射柠檬酸缓冲液作为空白对照 ,分别在注射 6周和 8周后 ,观察大鼠阴茎勃起功能 ,并采用免疫组化SP法检测糖尿病大鼠阴茎组织nNOS神经纤维的数量。 结果 :2组糖尿病大鼠的阴茎勃起率分别为 37.5 %和 14 .3% ,差异有显著性 (P <0 .0 5 ) ,均明显低于对照组 (P <0 .0 1)。 2组糖尿病大鼠nNOS神经纤维的表达明显低于对照组 (P <0 .0 1)。 8周组中糖尿病大鼠阴茎的勃起功能和nNOS神经纤维的数量明显低于 6周组 ,分别为 (37.6 0± 6 .76 )条和 (2 8.0 0±5 .2 9)条 ,即随着病程的延长 ,勃起功能和nNOS神经纤维的表达下降 (P <0 .0 5 ) ,而对照组大鼠nNOS神经纤维的数量差异无显著性 [(83.0 0± 3.2 2 )vs(81.0 0± 3.6 1) ]。 结论 :糖尿病严重影响勃起功能和nNOS神经纤维的表达。糖尿病大鼠阴茎海绵体组织中nNOS神经纤维的数量明显减少 ,且与病程正相关 ,这可能是糖尿病性勃起功能障碍的发病机理之一。

 
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