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阴茎海绵体
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  corpus cavernosum
    Effect of α-adrenoceptor antagonist on contractile response of the rabbit penile corpus cavernosum
    α-肾上腺素受体拮抗剂对兔阴茎海绵体收缩效应的影响
短句来源
    Effect of Berberine on the mRNA Expression of Phosphodiesterase Type 5 (PDE5) in Rat Corpus Cavernosum
    小檗碱对大鼠阴茎海绵体磷酸二酯酶5mRNA水平的影响
短句来源
    Objective: To further investigate the action mechanisms of berberine (Ber) and to assess the effects of Ber on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosum.
    目的 :检测大鼠阴茎海绵体中磷酸二酯酶 5 (PDE5 )mRNA的表达 ,进而探讨小檗碱 (berberine ,Ber)的分子作用机制。 方法 :通过逆转录酶链反应 (RT PCR)技术检测大鼠阴茎海绵体中PDE5mRNA的表达。
短句来源
    Effects of lotusine on cyclic nucleotide levels and contractile function in rat myocardium and rabbit corpus cavernosum
    洛土辛对心肌及阴茎海绵体环核苷酸含量和收缩功能的影响
短句来源
    The Effects of Testosterone Undecanoate on Relaxation of Rat Corpus Cavernosum Smooth Muscle in vitro
    安雄对去势大鼠离体阴茎海绵体平滑肌舒张性的影响
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  penile corpus cavernosum
    Effect of α-adrenoceptor antagonist on contractile response of the rabbit penile corpus cavernosum
    α-肾上腺素受体拮抗剂对兔阴茎海绵体收缩效应的影响
短句来源
  “阴茎海绵体”译为未确定词的双语例句
    PDE activity was assayed by using 3H-cGMP as substrate, the PDE isoenzymes hydrolyzed it to 3H-GMP, and 3H-GMP was further hydrolyzed to 3H-guanosine by 5′-nuclease of snake venom. Add scintillation cocktail to observe the PDE isoenzymes activity.
    方法以牛阴茎海绵体为原料 ,通过快速蛋白液相系统分离纯化得到PDE同工酶 ,然后以3 H cGMP为底物 ,经纯化的PDE同工酶催化水解为3 H GMP ,进一步在含 5′ 核苷酸酶的蛇毒液作用下 ,脱去 5′ 磷酸生成3 H 鸟苷 ,在闪烁剂激发下测定3 H 鸟苷的变化 ,绘制PDE活性曲线。
短句来源
    Effects of exogenous testosterone on isolated rabbit corpus caver -nosum penis
    外源性睾酮对离体家兔阴茎海绵体的影响(英文)
短句来源
    Optimal response has been achieved in 61 %.
    阴茎海绵体注射前列腺素E1可使61.7%的患者阴茎完全勃起;
短句来源
    CONCLUSION Sildenafil increases cGMP concentration in RCC is attributed to the augmentation of NO/cGMP pathway, and the accumulation of cGMP improves the relaxation of RCC.
    结论 以上结果表明枸橼酸西地非尔通过NO/cGMP呈剂量依赖性增强MCH和SNP对RCC的舒张作用 ,对动物阴茎海绵体组织舒张功能有显著性改善作用 ,从而大大提高动物性功能。
短句来源
    AIM: To observe the effect of domestic vs imported sildenafil on intracavernous pressure and erectile responses in an awake rat model.
    目的 :观察国产西地那非对大鼠阴茎海绵体腔内压和阴茎勃起的作用并与进口西地那非比较。
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  corpus cavernosum
Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).
      
Moreover, there is a potential risk of damage to the corpus cavernosum.
      
Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.
      
Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.
      
Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.
      
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  penile corpus cavernosum
The availability of such cultures should facilitate the study of endothelium-mediated responses which play an important role in the erectile function of human penile corpus cavernosum.
      


Between Jan. and Dec.1994,self-injection of aloprostadil sterile powder(prostaglandin E_1,caverject)for erectile dysfunction(ED)has been studied in 60 patients. Optimal response has been achieved in 61 %. 26.7% of patients experienced some mild pain after the injection. No penile hematoma,priapism or cavemous fibrosis has been Observed.Intracavernous injection of aloprostadil sterile powder is believed to be safe and effective for ED of various origin with relatively low side effects.

1994年1~12月,采用自我注射前列腺素E1方法,治疗不同病因的勃起功能障碍患者60例。阴茎海绵体注射前列腺素E1可使61.7%的患者阴茎完全勃起;仅26.7%的患者注射药物后,阴茎有轻微胀痛感;无阴茎血肿、异常勃起及海绵体纤维化等副作用。结果提示,前列腺素E1具有安全、有效和副作用小的特点,优于目前治疗勃起功能障碍的其它海绵体注射药物。

Effect of 5 kinds of α-adrenoceptor antagonist on contractile response of the rabbit penile corpus cavernosum was studied by using functional study. The results showed that the competitive effect of prazosin was the strongest among the five agents, followed by tamsulosin. No significant effect was found with phentolamine, terazosin and yohimbine. The results provide experiment basis for selecting and appling α-adrenoceptor antagonists in the treatment of penile erectile dysfunction.

本文采用离体组织收缩功能实验,比较了5种α-肾上腺素受体(α-AR)拮抗剂对去甲肾上腺素(NE)介导的兔阴茎海绵体收缩效应的影响,结果显示,哌唑嗪的拮抗作用最强,其次为tamsulosin。酚妥拉明,特拉唑嗪和育亨宾无显著拮抗作用。本实验结果为临床选用α-AR拮抗剂治疗阴茎勃起功能障碍提供了实验依据。

Sildenafil is the first oral therapeutic agent for erectile dysfunction. Sildenafil is a selective inhibitor of cGMP specific phosphodiesterase (PDE 5). Penile erection involves relaxation of the corpus cavernosum, an event mediated by NO and cGMP. The biological actions of cGMP are terminated by phosphodiesterase enzymes and PDE 5 is the major cGMP metabolising enzyme in this tissue. Sildenafil is relatively safe compared to erection injectables because it does not relax on isolated human corpus cavernosum,...

Sildenafil is the first oral therapeutic agent for erectile dysfunction. Sildenafil is a selective inhibitor of cGMP specific phosphodiesterase (PDE 5). Penile erection involves relaxation of the corpus cavernosum, an event mediated by NO and cGMP. The biological actions of cGMP are terminated by phosphodiesterase enzymes and PDE 5 is the major cGMP metabolising enzyme in this tissue. Sildenafil is relatively safe compared to erection injectables because it does not relax on isolated human corpus cavernosum, and does not cause priapism. Due to the tendency of abuse of sildenafil, its adverse cardiovascular associations with myocardial infaraction, ventricular arrhythmia and hypertension need to be alerted.$Key words sildenafil; sexual dysfunction; phosphodiesterase enzyme 5 was no remarkable difference between the two methods ( P >0 05) CONCLUSION: The sugarcoat had no effect on the determination of verapamil hydrochloride tablets

西地那非(俗名伟哥)是一种治疗阴茎勃起功能障碍的口服药物,其疗效约为70%~80%。阴茎勃起功能障碍的主要原因是阴茎海绵体供血不足,可能与缺少一氧化氮(NO)有关。NO可使鸟苷酸环化酶(GC)活化,在活化的GC作用下,鸟苷酸(GTP)转变成环鸟苷酸(cGMP);cGMP可被磷酸二脂酶(PDE)降解为5′-cGMP,后者无生物学效应,而cGMP则可引起阴茎海绵体平滑肌血管舒张,使阴茎迅速充血而勃起。研究表明,西地那非可抑制PDE的作用,使cGMP聚集,从而发挥其治疗作用。然而,目前也有关于用药不当致死的病例,美国已有69例(老年人占90%以上)因服用西地那非而致死的报告。本文仅就西地那非药理作用机制作一简要介绍。

 
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