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幽门
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  pylorus
    Methods:The gastric ulcer models produced by pylorus ligation,0.2N NaOH,0.6N HCI,indomethacin and cold- restraint stress were used.
    方法:采用幽门结扎型、O. 2N mol/L NaOH 型、0.6mol/L HCl 型、消炎痛型和冷束缚应激型胃溃疡模型。
短句来源
    ② 64 female SD rats were randomly divided into the control group, the B 1(45 mg/kg) group, the B 1(90 mg/kg) group, the ranitidine group, the pylorus were ligated according to the Shay model, 2 h later, the rats were killed and the gastric mucosa were removed and disposed, and the mucosa PGE 2 were measured.
    ②健康成年雄性SD大鼠 6 4只 ,随机分为生理盐水组 ,B1(4 5mg/kg)组、B1(90mg/kg)组、雷尼替丁组 (3.0mg/ 10 0g)共 4组 ,按Shay方法结扎幽门 ,2h后 ,处死大鼠 ,检测胃黏膜PGE2 含量。
短句来源
    Result: The Jiulingweikang capsules given ig 1.0,0.5 and 0.25 g/(kg·d) of 7 consecutive days could restrain the gastric ulcer induced by pylorus method;
    结果:连续7 d灌胃给予九灵胃康胶囊1.0,0.5,0.25 g·kg-1·d-1,均能明显抑制幽门结扎引起的胃溃疡;
短句来源
    The effects of Weixianzhi decoction on gastric ulcer induced by the ligation of pylorus
    胃仙治煎剂对大鼠幽门结扎型胃溃疡的作用
短句来源
    Study on Pharmacodynamics of Weishukang Capsules to Gastric Ulcer Induced by Ligating Pylorus
    胃舒康胶囊对大鼠幽门结扎型溃疡的作用研究
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    Danshen Yin can not play roles on gastric juice quantity,total acidity and pepsin activity of gastric fluid in gastric ulcer rats due to ostium pyloricum deligation, but can increase the contents of NO in gastric fluid (compared with model group P<0.01), increase the activity of SOD in gastric tissue and decrease the contents of MDA in gastric tissue (compared with model group P<0.05).
    丹参饮对幽门结扎型胃溃疡大鼠胃液量、胃液总酸度及胃蛋白酶活性无明显影响,但该方能明显提高大鼠胃液中NO含量(与模型组相比P<0.01),提高胃组织中SOD活性,并降低MDA含量(与模型组相比P<0.05);
短句来源
    In normal control group, the mitotic index of the antral mucosal epithelial and glandular cells was 5.93±1.23;
    正常胃窦粘膜上皮和幽门腺细胞分裂指数为5.93±1.23(x±s,下同);
短句来源
    Mucous membrane from gastric antrum was taken and cultured, and found that 136 cases of 226 patients were HP positive and the rate of positiveness was 60.18%.
    同时取胃窦粘膜做幽门螺旋菌(HP)培养,其中136例HP阳性(60.18%)。
短句来源
    (4)Huoxiang increased motility index of pylous,but Sharen decreased it .
    4藿香增加幽门环行肌条的运动指数,而砂仁则减小该部位的运动指数。
短句来源
    Results:(1) The DRRD 12g/kg given intraduodenally inhibited markedly gastric acid secretion and formation of ulcer in pylorus-ligated rats.
    结果:(1)十二指肠注射12g/kg 的干地黄煎剂,可抑制幽门结扎大鼠的胃酸分泌和胃溃疡形成;
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  pylorus
Heterogenous distribution of peptide-containing nerve fibres within the circular muscle layer of the human pylorus
      
The narrow region of the circular muscle layer bordering the submucosa in the pylorus contained a rich supply of VIP, SP, ENK and CGRP immunoreactive fibres; VIP fibres were most prominent with less SP and ENK fibres and moderate amounts of CGRP.
      
In the acute situation, intravenous erythromycin may alleviate gastroparesis, but probably exerts little beneficial effect beyond the pylorus; parenteral metoclopramide may be tried, but, here again, convincing evidence of efficacy is lacking.
      
In patients for whom all medical therapy fails, other options that are tried at experienced centers include the injection of botulinum toxin into the pylorus, placement of a feeding jejunostomy, and/or placement of a gastric electrical stimulator.
      
Surgical resection in the form of pylorus-preserving pancreaticoduodenectomy remains the optimal solution in the attempt to clarify the diagnosis and offer treatment with low complication rates.
      
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The Chian-Chung-Tang has been used clinically for treatment of gastric ulceration. It is composed of Hedysarum polybotrys,Cinnamom carsia,Paeonia lactiflora Gly- cyrrhiza uralensis, Angelica sinenss, Rhizoma Zingiberis, Fructus Zizyphi jujubae, and Saccharum Grannorum. 1.The induction rate of Shay rat ulceration together with the quantity of gastric secretion, free acidity, and total acidity was markedly dereased by Chian-Chung-Tang given subcutaneously, but the same effect was not found, when the drug was given...

The Chian-Chung-Tang has been used clinically for treatment of gastric ulceration. It is composed of Hedysarum polybotrys,Cinnamom carsia,Paeonia lactiflora Gly- cyrrhiza uralensis, Angelica sinenss, Rhizoma Zingiberis, Fructus Zizyphi jujubae, and Saccharum Grannorum. 1.The induction rate of Shay rat ulceration together with the quantity of gastric secretion, free acidity, and total acidity was markedly dereased by Chian-Chung-Tang given subcutaneously, but the same effect was not found, when the drug was given orally. 2.The movement of the stomach of the pigeon as well as the movement of the intestine of the rabbit in situ and that of rabbit and rat in vitro was depressed by the drug. 3.The drug was also found to antagonize the effect of pilocarpine and prostigmine upon the movement of intestine of rabbit in situ, and that by acetylcholine and pilocar- pine upon the movement of intestine of rabbit and rat in vitro. 4.The LD_(50) of Chian-Chung-Tang in mice was found to be 48g/kg given sub- cutaneously.

本文对加味黄芪建中湯的抗大白鼠胃溃疡作用及毒性作了初步探讨.建中湯煎剂给大白鼠皮下注射10克/公斤,可防止幽门结扎所致胃溃疡的发生;还能抑制胃液分泌、减少游离酸和总酸度;并使胃液pH值上升.但灌胃给药25克/公斤则不能防止溃疡的发生.建中湯煎剂对鸽胃正常运动及家兔腸运动都有抑制作用,并在一定程度上能对抗乙酰胆碱和毛果云香碱所致的腸痉挛.建中湯煎剂给小白鼠皮下注射的LD_(50)为48±7.2克/公斤.

Previous investigation has established that peat humicacid accelerated the healing of chronic experimental gastric ulcers in rats. Generally, gastric acid was considered as an important factor in evoking peptic ulcer. This study was designed to determine whether peat humic acid inhibit gastric acid secretion.This experiment was performed on 4 groups of male rats, to observe the influence of peat humic acid on gastric secretion induced by pyloric ligation (Shay rat), Shay rat plus histamine subcutaneous injection,...

Previous investigation has established that peat humicacid accelerated the healing of chronic experimental gastric ulcers in rats. Generally, gastric acid was considered as an important factor in evoking peptic ulcer. This study was designed to determine whether peat humic acid inhibit gastric acid secretion.This experiment was performed on 4 groups of male rats, to observe the influence of peat humic acid on gastric secretion induced by pyloric ligation (Shay rat), Shay rat plus histamine subcutaneous injection, Shay rat plus pilocarpine subcutaneous injection and Shay rat plus pentagastrin muscular injection. The dose of peat humie acid was 50mg/kg i.p, The results showed that peat humic acid inhibited acid ontput ou all the above 4 groups.The degree of inhibition was 75—88% which were statistically highly significant (p<0.001), as compared with the control.

本工作用雄性大鼠进行实验,观察泥炭腐植酸对大鼠胃酸分泌的影响。实验分4组:即泥炭腐植酸对幽门结扎大鼠(Shay大鼠),Shay大鼠加皮下注射组织胺,Shay大鼠加皮下注射毛果芸香碱以及Shay大鼠加肌肉注射五肽胃泌素所引起胃酸分泌的影响。泥炭腐植酸剂量为50毫克/公斤体重腹腔注射。结果表明:泥炭腐植酸对以上4组所引起的胃酸分泌均有明显的抑制作用。

The role of Furazolidone in the patient suffering from peptic ulcer and in pylorus-ligated rat was reported previously. They suggested that the cytoprotection of Furazolidone might be due to its inhibitory effect in gastric secretion. The result of the present experiment indicates that the gastric ulcer induced by restraintsoakage in rat can also be prevented by Furazolidone. This effect cannot be blocked by Indomethacin which is well known to be an inhibitor of endogenous Prostaglandins in gastric mucosa. This...

The role of Furazolidone in the patient suffering from peptic ulcer and in pylorus-ligated rat was reported previously. They suggested that the cytoprotection of Furazolidone might be due to its inhibitory effect in gastric secretion. The result of the present experiment indicates that the gastric ulcer induced by restraintsoakage in rat can also be prevented by Furazolidone. This effect cannot be blocked by Indomethacin which is well known to be an inhibitor of endogenous Prostaglandins in gastric mucosa. This result shows that the cytoprotection of Furazolidone is not caused by the inhibition of endogenous PGs. By radioimmunoassay of gastrin in serum, it is found that Furazolidone can inhibit the concentration of gastrin in serum in this experimental condition, it is suggested that the inhibition of the synthesis and secretion of gastrin may be the mechanism of the cytoprotection of Furazolidone.

痢特灵对消化性溃疡及幽门结扎胃溃疡的作用,以前已有报导;此作用可能与痢特灵抑制胃酸分泌有关。本实验将大鼠束缚于网络板上,置于26℃~27℃水中六小时,使大鼠胃粘膜受损。实验证明痢特灵对束缚-水浴性胃溃疡(应激性溃疡)也有保护作用。此作用不被消炎痛(具有抑制胃粘膜内源性合成前列腺素的作用)所阻断。此结果表明痢特灵的细胞保护作用不是通过抑制胃粘膜合成前列腺素而致。此外,我们用放射免疫法测定了大鼠血清胃泌素含量,发现痢特灵具有抑制本实验条件下胃泌素分泌的作用。我们认为痢特灵细胞保护作用的机理很可能是抑制胃泌素的合成和分泌。

 
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