Compared with TPN group,In the TPN+L-Arg group,the level of serum and liver NO were increased significantly ( P <0.05),however,serum AST was decreased significantly ( P <0.05) but ALT was not,liver TG was decreased significantly ( P <0.05) and the degree of fatty degeneration in the liver was lessened.
However, TP and EGCG treatment improved histological changes, and significantly decreased the levels of plasma endotoxin and serum TNF-α, IL-1, IL-18, as well as the expression of CD14, LBP, TNF-α, IL-1 and IL-18 mRNA (P < 0.05 or P < 0.01). Fatty degeneration was still observed in TP and EGCG treatment group, but focal necrosis and inflammatory cell infiltration disappeared.
The liver steatosis had obvious negative correlation with HDL content after scald(r=-0.37 , P<0.01) , but it had positive correlation with the ALP content(r=0.45 , P<0.01) , TG content(r=0.25 , P<0.01) and liver weight/body weight ratio(r=0.440, P<0.01).
⑤The hepatic steatosis of the model group was more severe compared with the control group (P < 0.05),the training group was obviously lighter than the model group (P < 0.05),but still more serious than the control group (P < 0.05).
In the treatment group,the value of ALT,AST,TG and MDA decreased and SOD activity increased; CYPⅡE1 expression was decreased; the degree of fat degeneration and inflammatory necrosis was ameliorated remarkably.
In result 2.5% of the rats got slight hepatic enzymes increase, and 6.25% of the rats got slight fat degeneration for hepatic tissue specimens. Most of the rats with abmormal results occurred in the toxic and lethiferous group, and there was the increasing tendency with the increase of dose.
Their hepatopancreas were swollen and pale, accompanied by fatty degeneration, fatty necrosis of hepatocytes, and atrophy of the pancreas.
Muscular dystrophy was associated with considerable variation of fibre size, hypertrophy of individual fibres, centralization of nuclei, split fibres, relatively slight degrees of degeneration, fatty degeneration, and interstitial fibrosis.
Muscle MRI findings were fatty degeneration and loss of bulk.
Operative repair of large tears of the rotator cuff can be technically challenging because of retraction and inelasticity of the tendons, bursal scarring, muscle atrophy and fatty degeneration.
Reye's syndrome (Rs) is an acute illness in children manifested by encephalopathy and fatty degeneration of the liver.
Hepatic steatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liver tissues.
Furthermore, macrovesicular steatosis predominantly located in acinar zone 3 was the main histologic feature of NAFLD and lobular inflammation was usually presented mildly.
According to the statistic analysis, hepatic steatosis was positively correlated with lobular inflammation, hepatocytic ballooning and fibrosis (r = 0.587, 0.488, 0.374, respectively, all P value >amp;lt; 0.01).
The number of microgranulomas, lipogranulomas and apoptotic bodies increased following severity of steatosis, lobular inflammation and fibrosis.
We suggest that the role of portal inflammation should be emphasized besides hepatic steatosis, lobular inflammation, hepatocyte ballooning and fibrosis in diagnosis and evaluation of NAFLD.