The positive rate of TIMP 1 expression is 78 82%. A significant negative correlation was found between TIMP 1 expression and tumor invasion, lymph node metastasis and TNM staging(Pearson contingency coefficient P=0 01, P=0 03, P=0 02, P<0 05).
The expressions of p53,c-erbB-2 ,p21 were positively correlated with grade of tumor differentiation ,the depth of tumor invasion and clinical different stages (r=0.53, r=0.67, r=0.48, P<0.05), and the expression of nm23 was negatively correlated with grade of tumor differentiation,the depth of tumor invasion and clinical different stages (r=-0.36, P<0.05).
Results The positive rate of MMP 9 expression is 90 50%. The expression of MMP 9 is positively related to the tumor invasion, lymph node metastasis, index of ki 67 and TNM staging(Pearson contingency coefficient P=0 03, P=0 02, P=0 000, P<0 05, 0 01, respectively).
Results In 100 specimens, the infiltration was found in 36 cases at the distance of 0.5 cm, 26 cases at the distance of 1.0 cm, 15 cases at the distance of 1.5 cm, and no infiltration was found at the distance of 2.0 cm. The distance of tumor infiltration was positive correlated with the size of tumor, but was negative correlated with the age.
The expression of cyclin D1 was significantly correlated with Lauren type of tumor, the expression of cyclin E was significantly correlated with tumor differentiation, infiltration and stage, while the expression of P27 protein was significantly correlated with tumor infiltration,lymph nodes metastasis and stage.
Methods The expression of Cat-D and nm23-H1 were detected immunohistochemically in 74 colorectal carcino ma specimens, and its correlated with clinicopathological,tumor infiltration and metastasis were analyzed retrospectively.
Results Positive rate of either p53 or c-erbB-2 expression was 67.4% (29/43). The expression of p53 was independent to histopathological classification (P>0.05), but significantly related to tumor infiltration and lymph node metastasis of esophageal carcinoma (P<0.01).
Expression and significance of tumor infiltrating dendritic cells in renal cell carcinoma
The activity of interleukine 2 (IL-2) in culture supernatants of lymphokine-activated killer (LAK) cells and tumor infiltrating lymphocytes (TIL) as well as cytotoxicity of LAK cells on cultured leukemic cells were determined by MTT colorimetry.
Separation and expansion of tumor infiltrating lymphocytes of digestive systemin Vitro and their cytotoxicity
FasL protein expression and the number of tumor infiltrating lymphocytes (TILs) in 80 specimens of colorectal carcinoma were detected by immunohistochemitry.
The induction of murine tumor infiltrating lymphocytes (TIL) by interleukin-2 or T cell growth factor