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自身免疫性     
相关语句
  autoimmune
     The Immunopathogenesis and Synergy of IL-12 and IL-18 in Adoptive Experimental Autoimmune Neuritis (AT-EAN)
     在过继性实验性自身免疫性神经炎中IL-12和IL-18的免疫发病机制及协同机制的研究
短句来源
     Study of Cloning and Expression of Human High-Affinity IgE Receptor Alpha-Chain Gene and the Pathogenesis of Autoimmune Chronic Urticaria
     高亲和力IgE受体α链基因克隆、表达及自身免疫性慢性荨麻疹发病机制的研究
短句来源
     Study on Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis by EGb761 and Minocycline
     银杏叶提取物EGb761及米诺环素对实验性自身免疫性脑脊髓炎及多发性硬化的防治研究
短句来源
     Therapeutic Effect of PLP_(193-151)-Specific T Lymphcytes Modified by α-Melanocyte Stimulating Hormone Gene on Experimental Autoimmune Encephalomyelitis
     α黑素细胞刺激素基因修饰的PLP_(139-151)特异性T淋巴细胞对实验性自身免疫性脑脊髓炎的治疗作用
短句来源
     Study of the Establishment of the Animal Model of Premature Ovarian Failure and the Treatment of Autoimmune Premature Ovarian Failure with Oral Tolerance
     卵巢早衰动物模型的建立及口服耐受治疗自身免疫性卵巢早衰的相关研究
短句来源
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  autoimmunity
     Value of Fas-L Expression of Glandular Lymphocyte and Serum sAPO-1/Fas Determining in Autoimmunity Thyroiditis
     自身免疫性甲状腺炎腺体内淋巴细胞Fas-L的表达及血清sAPO-1/Fas测定的意义
短句来源
     Objective: Guillain-Barre syndrome (GBS) is an autoimmunity polyneuropathies because of nonspecific infection.
     目的:吉兰-巴雷综合征(Guillain-Barre syndrome, GBS)是由于非特异性感染所引起的自身免疫性多发性周围神经病。
短句来源
     Recently,the gene encoding cytotoxic T lymphocyte associated antigen 4(CTLA-4) has been suggested as a candidate gene conferring susceptibility to autoimmunity.
     近年大量研究表明,细胞毒T淋巴细胞相关抗原4(cytotoxic T lymphocyte-assoc iated antigen 4,CTLA-4)基因多态性与诸多自身免疫性疾病的发生风险可能相关,因而被确定为自身免疫性疾病的候选遗传易感基因。
短句来源
     Animal Model of Experimental Autoimmunity Orchitis in BALB/c Mice
     BALB/c鼠自身免疫性睾丸炎动物模型的制作
短句来源
     AIM: To test the hypothesis that atorvastatin affects T cell-mediated autoimmunity through modulating the balance of Th1/Th2 and reduces the severity of EAM.
     目的:探讨阿托伐他汀对实验性自身免疫性心肌炎(EAM)大鼠Th1/Th2偏离的影响及对EAM的治疗价值。
短句来源
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  experimental autoimmune
     Study on the blood CD4~+CD25~+T cells of rats with experimental autoimmune encephalomyelitis
     实验性自身免疫性脑脊髓炎大鼠血CD4~+CD25~+T细胞的研究
短句来源
     Establishment of experimental autoimmune encephalomyelitis model in C57BL/6 mice
     C57BL/6小鼠实验性自身免疫性脑脊髓炎模型的建立
短句来源
     Cyclosporin A and 1,25-Dihydroxyvitamin D_3 in the Prevention and Treatment of Experimental Autoimmune Thyroiditis
     环孢菌素A和1,25(OH)_2D_3防治实验性自身免疫性甲状腺炎的研究
短句来源
     Objective To explore effects of levamisole (LMS) on expressions of CD4,CD8,CD28 and CD152 on mononuclear cells in spinal cords of rats with experimental autoimmune encephalomyelitis (EAE).
     目的探讨左旋咪唑(Levamisole,LMS)对实验性自身免疫性脑脊髓炎(experi mental autoimmune encephalomyelitis,EAE)大鼠脊髓内单个核细胞CD4、CD8、CD28及CD152表达的影响及其意义。
短句来源
     Effects of Levamisole on the Expressions of IFN-γ mRNA and TGF-β_1 mRNA in Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis
     左旋咪唑对实验性自身免疫性脑脊髓炎脊髓IFN-γ、TGF-β_1 mRNA表达的影响
短句来源
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  latent autoimmune
     Association of HLA-A0205,HLA-A30 and MICA Gene Exon 5 with Latent Autoimmune Diabetes in Adults (LADA)
     HLA-A0205,HLA-A30及MICA外显子5多态性与成人迟发自身免疫性糖尿病(LADA)的关系研究
短句来源
     Changes of CD4~+CD25~+T cells in patients with Latent autoimmune diabetes in adults
     成人隐匿性自身免疫性糖尿病患者CD4~+CD25~+T细胞的变化研究
短句来源
     Objective To investigate the frequency and etiopathogenetic relevance of CD_4+ CD_ 25 + immunoregulatory T cells in latent autoimmune diabetes in adults (LADA).
     目的探讨成人隐匿性自身免疫性糖尿病(LADA)患者外周血免疫调节性CD4+CD25+T细胞亚群的变化及其意义。
短句来源
     1.The Study of Insulin Sensitivity and Islet β Cell Function of Latent Autoimmune Diabetes in Adults 2.The Immune Mechanism Study of Latent Autoimmune Diabetes in Adults
     1.成人隐匿性自身免疫性糖尿病胰岛素抵抗与胰岛β细胞功能的研究 2.成人隐匿性自身免疫性糖尿病免疫机理探讨
短句来源
     Clinical Analysis of 3 Cases of Latent Autoimmune Diabetes in Adults (LADA) Combined with Graves Disease
     成人隐匿性自身免疫性糖尿病合并Graves病3例临床分析
短句来源
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  autoimmune
The hypothesis of "autoimmune testing" of mating partners assumes the formation of an immune-based individual perception system involving intravital selection of direct or inverse replica of self key antigens or alarm molecules.
      
The presence of the friend/foe identification systems in nearly all living organisms suggests the formation of the mechanisms of autoimmune testing of potential mating partners at the earliest stages of evolution.
      
Most of the data accumulated throughout the years on investigation of catalytic antibodies indicate that their production increases on the background of autoimmune abnormalities.
      
The different approaches to induction of catalytic response toward recombinant gp120 HIV-1 surface protein in mice with various autoimmune pathologies are described.
      
Increased proteolytic activity of polyclonal antibodies in SJL mice encouraged us to investigate the production of antigen-specific catalytic antibodies on the background of induced experimental autoimmune encephalomyelitis (EAE).
      
更多          
  autoimmunity
Induction of an autoimmunity-like process using regular mercury chloride administration to SJL mice
      
Induction of autoimmunity against endogenous neuroregulators isatin and cholecystokinin as a method of modeling and correction o
      
This article excludes the autoimmunity hypothesis for Chagas disease because it has been extensively reviewed elsewhere, and summarizes the various alternative hypotheses that have been advanced over the years.
      
The antithyroid antibodies (thyroglobulin antibodies, microsomal antibodies) showed normal titres and did not suggest disturbances of thyroid autoimmunity in the patients with ALS.
      
We report the case of a patient with the unusual combination of migraine, chorea, and retinal arterial thrombosis along with laboratory evidence of autoimmunity.
      
更多          
  experimental autoimmune
Increased proteolytic activity of polyclonal antibodies in SJL mice encouraged us to investigate the production of antigen-specific catalytic antibodies on the background of induced experimental autoimmune encephalomyelitis (EAE).
      
Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardia
      
Suppression of experimental autoimmune encephalomyelitis by a new specific leukotriene biosynthesis inhibitor
      
Interleukin-6 (IL-6) plays an important role in the regulation of the inflammatory response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).
      
Much of it stems from models of experimental autoimmune encephalomyelitis, generated by inoculation of animals with central nervous system antigens such as MBP, PLP, S100 and MOG or peptides thereof.
      
更多          
  latent autoimmune
Diabetic neuropathy in patients with "Latent Autoimmune Diabetes of the Adults" (LADA) compared with patients with type 1 and ty
      
In non-insulin-dependent diabetic (NIDDM) patients, it has been suggested that the presence of GADab may identify a subset of latent autoimmune diabetes in adults (LADA).
      
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
      
This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).?Methods.
      
We found SOX-13 antibodies to be present in 11 of 125 (8.8 %) patients with newly diagnosed Type I diabetes and in 3 of 43 (7.0 %) patients with latent autoimmune diabetes in adults.
      
更多          
  其他


42 autoimmune thyroiditis (AIT) patients surgically treated and pathologically proved were followed up and their clinical data were analysed with regard to the diagnosis of this disease. The five markers by Fisher et al in 1975 for the diagnosis of the disease were reviewed. The key in diagnosis of AIT lies in the assaying of the relatively specific circulating antithyroid antibodies, chiefly TGA and MCA. If both of these tests are negative this disease seems to be unlikely. The haemagglutination and ELISA methods...

42 autoimmune thyroiditis (AIT) patients surgically treated and pathologically proved were followed up and their clinical data were analysed with regard to the diagnosis of this disease. The five markers by Fisher et al in 1975 for the diagnosis of the disease were reviewed. The key in diagnosis of AIT lies in the assaying of the relatively specific circulating antithyroid antibodies, chiefly TGA and MCA. If both of these tests are negative this disease seems to be unlikely. The haemagglutination and ELISA methods were adopted in assaying TGA in all the cases, having positive results in 88%. In most of the normal individuals or patients inflicted with other thyroid diseases, with the exception of hyperthyroidism, TGA was negative. Thus in the TGA positive patients, AIT can be diagnosed with considerable certainty. In those patients with negative results, some other additional investigations are recommended or a needle biopsy may be carried out.

本文报道42例经手术后病理确诊的自身免疫性甲状腺炎,分析其临床及实验室资料,从中探讨本病的临床诊断问题及甲状腺自身抗体(TGA)的意义。

Autoimmune hemolytic anemia is an acquired anemia. 21 cases werereported. The ages of these patients varied from 11 months to 12 yearswith only 4 of them under 3 years. 12 cases were of idiopathic form and3 cases presented Evans Syndrome. 9 cases were secondary to systemiclupus erythematosus, chronic purulent otitis media, subsepsis allergica,lymphadenopathy and chronic hepatitis B surface antigenemia. It wasoften difficult to date the exact onset of the disease. The symptomsgenerally developed slowly and insidiously...

Autoimmune hemolytic anemia is an acquired anemia. 21 cases werereported. The ages of these patients varied from 11 months to 12 yearswith only 4 of them under 3 years. 12 cases were of idiopathic form and3 cases presented Evans Syndrome. 9 cases were secondary to systemiclupus erythematosus, chronic purulent otitis media, subsepsis allergica,lymphadenopathy and chronic hepatitis B surface antigenemia. It wasoften difficult to date the exact onset of the disease. The symptomsgenerally developed slowly and insidiously in most cases. Anemia, weakness, fever and hepatomegaly were common in bothprimary and secondary cases. Coombs' test were positive in all patients,5 cases were of the IgG type. From the point of view of "Comparative Immunology", autoimmunediseases in human are similar to those of NZB mice.

本文报告21例自身免疫性溶血性贫血。其中原发性12例,继发性9例,全部经抗人球蛋白试验证实。并首先分出5例IgG型。原发与继发性临床上有时鉴别困难。从“比较免疫学”观点认为:人类的自身免疫过程与NZB鼠类似,应早诊早治,免使病程迁延。导致多数器官受损。

40 rabbits were divided randomly into 4 groups: ①uninfected experimental group treated with different total doses in various courses,②infected experimental group,③infected control group, and④ normal control group. Pathomorphology, immunofluorescence specific lymphocytic transformation test and skin test were used w find that the allergic reactions both type Ⅲ and Ⅳ play an important role in the pathogenesis of nithiocyamine induced hepatic lesions, also find especially in the uninfected experimental group,Some...

40 rabbits were divided randomly into 4 groups: ①uninfected experimental group treated with different total doses in various courses,②infected experimental group,③infected control group, and④ normal control group. Pathomorphology, immunofluorescence specific lymphocytic transformation test and skin test were used w find that the allergic reactions both type Ⅲ and Ⅳ play an important role in the pathogenesis of nithiocyamine induced hepatic lesions, also find especially in the uninfected experimental group,Some important pathological features,sacb as: hepatic autoimmune granulom (4/22)and cholangiolar proliferation with pericholangiolitis(21/22)etc. No significant differences could be found statistically (P>0.05), there fore the occurrence and the degree of various pathological changes have no definite interrelactionship with the dose and the duration of the drug.The hepatic lesions of the experimental animals with the exception of one rabbit were rather mild.

实验采用家兔40只,随机分成4组:①单纯服药组,用不同疗程和剂量;②感染治疗组;③感染对照组;④正常对照组,我们应用病理形态学、免疫荧光、特异性淋巴细胞转化试验和皮肤试验等项进行药物性肝损害发病机制的研究。实验结果表明本药所致肝损害主要是变态反应性(兼有Ⅲ及Ⅳ型)机制。我们看到实验动物肝内有重要的病理形态学变化,以单纯服药组较为明显,主要有肝自身免疫性肉芽肿(4/22),细胆管增生及其周围炎(21/22)等,分别经显著性检验,无显著差异(P>0.05),表明各项病变的发生及其程度与药量和疗程无平行关系。本实验组家兔肝脏病变除1只兔外均较轻。

 
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