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Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations,...

Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations, however, were statistically insignificant. The total peripheral resistance was not much influenced by guanethidine in normal dogs, yet markedly diminished in hypertensive dogs. Diuresis was evident during the 1-hour postmedication period in both models. In hypertensive dogs, i.v. administrations of guanethidine caused a conspicuous rise of RBF and GFR, but a great reduction of the renal vascular resistance. In normal rats, following an i.p. injection of 20 mg/kg, the circulating blood volume (studied with I~(131)-labeled serum protein) exhibited a slight but non-significant increase within 3 hours, and returned to the original level at 24 hours. No significant change was found in DOCA-treated rats. Normal rats receiving guanethidine revealed an increase of blood volumes in all organs, especially spleen and kidney. These results demonstrate that the hypotensive action of guanethidine is not via the reduction of blood volume, but by way of a vasodilator action, which particularly amends the ischemic state of kidney and thus alleviates the pathologic process of renal hypertension.

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降...

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通过循环血量的減少,而是由于外周血管的扩张所致。胍乙啶能扩张腎血管,改善腎缺血状态,从而緩解腎型高血压的病理生理过程。

The effect of high altitude on the left ventriclar function has been observed on 78 high altitude temporary residents at 4,800m. and 2,800 m. above sea level. 38 individuals at sea level were taken as control. Systolic time intervals were determined by the method of simultaneous recording of electrocardiogram, phonocardiogram and external carotid pulse tracing. A prolonged pre-ejection period, pre-ejection period/left ventricular ejection time ratio and a shortened left ventricular ejection time were noted in...

The effect of high altitude on the left ventriclar function has been observed on 78 high altitude temporary residents at 4,800m. and 2,800 m. above sea level. 38 individuals at sea level were taken as control. Systolic time intervals were determined by the method of simultaneous recording of electrocardiogram, phonocardiogram and external carotid pulse tracing. A prolonged pre-ejection period, pre-ejection period/left ventricular ejection time ratio and a shortened left ventricular ejection time were noted in the 4,800 m.group and the 2,800 m.group, yet the total electromechanical systolic time of both groups remained unchanged. The alterations in systolic time intervals werethe associated with the stroke volume, determined by echocardiogr-aphy.No difference was observed between the heart rates of the high altitude residents and that of the control.It seems that an increased afterload and a decreased preload of the left ventricle are presumably concerned with the increased pre-ejection period/ left ventricalar ejection time ratio.

为了解高原对左室功能的影响,在海拔4500米和2800米地区对移居者作了心脏收缩间期(STI)的测定。结果表明,移居者与平原对照组相比,心率无显著差别,而射血前期(PEP)延长,左室射血时间(LVET)缩短,射血前期与左室射血时间的比值(PEP/LVET)增大,电机械收缩期(QS_2)则无明显改变。推测STI的改变与左室前负荷的减小及后负荷的增大有关。

The electrocardiographic and vectorcardiographic changes of healthy altitude residents were observed. They were divided into 5 groups according to the intensity of labour engaged in and the different height above sea level ( 80m. 2,800m. and 4,500m. ) where they had resided in. The main electrocardiographic changes with rise in height above sea level were:increase in heart rate, prolongation of Q-Tc interval, right axis deviation of P wave and QRS complex in most cases , left axis deviaton in a few cases and...

The electrocardiographic and vectorcardiographic changes of healthy altitude residents were observed. They were divided into 5 groups according to the intensity of labour engaged in and the different height above sea level ( 80m. 2,800m. and 4,500m. ) where they had resided in. The main electrocardiographic changes with rise in height above sea level were:increase in heart rate, prolongation of Q-Tc interval, right axis deviation of P wave and QRS complex in most cases , left axis deviaton in a few cases and those changes reflecting right ventricular preponderance (such as.Rv1≥1.0mV,RV1+SV5≥1.2mV,RV1+Sy5/SV1+RV5,R/S(Q)aVR≥1.0. R/SV1 ≤1.0 and R/SI≤1.0). The number of abnormal and doubtful electrocardiograms increased, expecially the changes indicating right ventricular hypertrophy.The general changes of vectorcardiograms were: the spatial axis of the QRS loop shifted towards the right posterior superior octant and the T loop towards the left posterior inferior octant. The number of abnormal vectorcardiograms increased. From the preliminary study of the vectorcardiograms and electrocardiograms, we divided the tracings into 5 types according to their dominant pattern, they were: type C, type Ⅱ (including 2 subtypes: Ⅱ A, Ⅱ B), right superior, right inferior and right anterior types.The influences of altitudes on electrical activity of heart were briefly discussed.

本文观察了不同海拔高度和不同劳动强度5个组的心电图和心电向量图的变化。心电图的主要改变是随海拔高度的增加,心率加快,Q-Tc间期延长,P电轴右移,QRS轴多数右移,少数左移,的趋势右移;异常和可疑心电图增加,右室肥厚者增多尤为明显。心电向量图的变化是QRS空间综合向量向右、后、上方偏移,T向量向左、后,下方偏移;异常心电向量图增多,共发现五型右室肥厚,即C型、Ⅱ型(包括Ⅱ-A,Ⅱ-B两个亚型),右上型、右下型和右前型。作者还简要地讨论了高原环境对心脏电活动的影响。

 
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