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    Research of Kudzu (Pueraria Lobata) Flavonoids Effects on the Apoptosis of Human Leukemia Cells
    葛根黄酮致人白血病细胞凋亡的效应研究
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    Transcription Factor κB Regulated Tissue Factor in APL Cells and Effects of PNS
    核转录因子NFκB对APL细胞组织因子的调节及三七甙影响的实验研究
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    The experimental study of effect of overall treatment tune on Lewis lung carcinoma
    疗程时间对Lewis肺癌治疗效应影响的实验研究
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    Diagnostic value of free- to- total PSA in prostate cancer
    游离前列腺与前列腺特异性抗原比值在前列腺癌诊断中的价值
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    The 5-year survival rates of the 3 types of patients after the operation were 34% for Type I, 27.5% for Type II, and 24.5% for Type III (P<0.05).
    3型肿瘤术后5年的生存率分别为Ⅰ型34%,Ⅱ型27.5%,III型24.5%(P<0.05)。
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The metabolism of NaHSO_3-andrographolide in rats was studied by means of NaHSO_3(~(35)S)-andrographolide.

本文是用放射性同位素~(35)硫标记NaHSO_3-穿心莲内酯做动物实验,以阐明NaHSO_3(~(35)S)-穿心莲内酯在体内的代谢过程。动物实验是用NaHSO_3(~(35)S)-穿心莲内酯注入大白鼠。实验用的药物是用NaHSO_3(~(35)S)溶液用加成反应标记于穿心莲内酯的第12位碳上。标记率达92%。标记化合物的性能和浓度与治疗用商品注射针剂NaHSO_3-穿心莲内酯相同。大小便标本是注射后连续按一定间隔时间取出的,组织标本是按一定间隔时杀死的动物身上取出的。标本的放射性是用液体闪烁计数器测量的。标记化合物在大白鼠的体内代谢表明,NaHSO_3(~(35)S)-穿心莲内酯进入体内后,在中枢神经系统中主要选择性地蓄积于脊髓中,并且呈下行性蓄积,可因此导致肌紧张度减低和外周血管扩张,引起体温下降。在脏器中此药较明显地蓄积于十二指肠、直肠,这是临床采用此药治疗肠炎和菌痢的有力依据。实验也指出,此药在体内迅速吸收,迅速排泄,72小时内在尿粪中排除量达86.2%,建议临床酌情增加剂量或次数。NaHSO_3(~(35)S)-穿心莲内酯大多在尿中主要以原形排出,从而考虑对泌尿系统感染可能有一定疗效。

Nuclear envelope (NE) surrounding the periphery of the nucleus of interphase eukaryotic cells, is one of the characteristic biomembrane systems. It has been known that the contour of the nucleus of some malignant cells was not regular, and the perinuclear cisternae as well as the internal dense lamillae was thicker than that of the normal cells. These phenomena, however, are still lacking the quantitative informations.

本文报告通过细胞形态定量分析技术研究小鼠正常肝细胞、腹水型肝癌、实体型和腹水型肉瘤-180及黑色素瘤等恶性细胞核膜超显微结构的结果。可见,肝癌等恶性肿瘤细胞核膜表面积与核体积的比例显著大于对照肝细胞,约增长了40%,定量证实了肿瘤细胞核膜可随不断增殖分裂的需要而增加其核膜表面积。但上述四种实验性肿瘤细胞核膜的厚度与肝细胞间无显著差异,因此认为肿瘤细胞核周隙之增宽或内纤维层的增厚尚缺乏定量数据的证明。

Hepatic artery ligation(HAL)for nonresectable liver cancer was performed in 68cases in the 6 yr started from Feb 1974.The indications were emergency hemostasisfor ruptured hepatoma(5),bilateral involvement of liver(30),invasion into portahepatis(28),and advanced liver cirrhosis or nonresectable metastatic cancer(5).Siteof HAL:right hepatic artery(34),left hepatic artery(13),proper hepatic artery(13),and common hepatic artery(8).Immediate results:operative mortality,2.9%;amelio-ration of clinical manifestations,84.8%;decrease...

Hepatic artery ligation(HAL)for nonresectable liver cancer was performed in 68cases in the 6 yr started from Feb 1974.The indications were emergency hemostasisfor ruptured hepatoma(5),bilateral involvement of liver(30),invasion into portahepatis(28),and advanced liver cirrhosis or nonresectable metastatic cancer(5).Siteof HAL:right hepatic artery(34),left hepatic artery(13),proper hepatic artery(13),and common hepatic artery(8).Immediate results:operative mortality,2.9%;amelio-ration of clinical manifestations,84.8%;decrease in liver size,45.4%.Duration ofremission:2-24 mo.Most had a decrease in serum AFP level and AFP became nega-tive in 2 cases,persisting for 7 and 15 too.Long term results:In 52 cases followed,the median survival period,half yr and one yr survival rates were 7.0 mo,56.4% and21.8% respectively,in contrast to 3.9 mo,12% and 4% of 25 simple laparotomycases.

本文报告用肝动脉结扎术治疗不能切除的肝癌68例,其中原发性肝细胞癌64例,原发性肝胆管癌1例,转移性肝癌3例。结扎部位:肝右动脉34例,肝左动脉及肝固有动脉各13例,肝动脉8例。手术死亡率2.9%。术后56例症状有缓解,30例肝脏有所缩小,约80.1%的病例血清甲胎蛋白降低一半以上。随访到52例的术后中位生存期为7.0月。讨论了本手术治疗肝癌的价值、影响效果的因素、手术指征及提高疗效的措施。

 
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