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   霉酚酸酯 在 泌尿科学 分类中 的翻译结果: 查询用时:0.229秒
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霉酚酸酯
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  mycophenolate mofetil
    Objective To investigate the efficacy of immunoadsorption(IA)in combination with tacrolimus(FKS06)and mycophenolate mofetil(MMF)in the treatment of C4d-positive acute humor- al rejection(AHR)of renal transplants.
    目的探讨免疫吸附(IA)联合他克莫司(FK506)和霉酚酸酯(MMF)治疗C4d阳性的急性体液性排斥反应(AHR)的临床效果。
短句来源
    Clinical use of mycophenolate mofetil in renal transplantation
    霉酚酸酯在肾移植术后的临床应用
短句来源
    Mycophenolate mofetil in the treatment of primary nephrotic syndrome
    霉酚酸酯治疗原发性肾病综合征的临床观察
短句来源
    Effects of mycophenolate mofetil combined with low dose cyclosporine A on acute rejection in renal transplantation patients
    霉酚酸酯联合低剂量环孢素A防治肾移植急性排斥反应
短句来源
    Experimental study of mycophenolate mofetil in preventing renal interstitial fibrosis in rats
    霉酚酸酯抑制大鼠肾间质纤维化的研究
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  “霉酚酸酯”译为未确定词的双语例句
    Clinical observation on the early application of Cellcept following cadaveric renal transplantation
    肾移植患者术后早期应用霉酚酸酯的临床观察
短句来源
    Mycophenolate motefil for membranous nephropathy with primary nephrotic syndrome; a clinical observation
    霉酚酸酯治疗膜性肾病型原发性肾病综合征临床观察
短句来源
    Clinic observation of treatment of 16 case of hardy remedical nephropathy syndrome with mycophenolate mefetil
    霉酚酸酯治疗难治性肾病综合征16例临床观察
短句来源
    Immunosuppressive therapy for renal transplant recipients with Cellcept, Cyclosporine A and Prednison
    联合霉酚酸酯、环孢素A和泼尼松应用于肾移植患者免疫抑制治疗
短句来源
    3. To observe the effects of glucocorticoids (GC) and mycophenolate mofe-fil (MMF) in the treatment of CKD caused by glomerular disease.
    3、观察糖皮质激素(GC)、霉酚酸酯(MMF)等对肾小球疾病所致CKD的疗效。
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  mycophenolate mofetil
A simple and practical micellar electrokinetic capillary chromatography (MEKC) method is proposed for the quantitation of immunosuppressive drugs such as azathioprine (AZA), mycophenolate mofetil (MMF), cyclosporine A (CyA) and tacrolimus (FK 506).
      
In clinical transplantation mycophenolate mofetil (MMF) has become an attractive immunosuppressive agent.
      
Plasma samples from 60 transplant patients on mycophenolate mofetil therapy were analysed using validated capillary electrophoresis (CE) method to determine mycophenolic acid (MPA) and its main metabolite mycophenolic acid glucuronide.
      
There are a number of small case series describing the efficacy of immune-modulating agents, such as azathioprine, cyclophosphamide, cyclosporine A, interferon-alpha, and mycophenolate mofetil.
      
Newer medications with potentially more benign side effect profiles, such as mycophenolate mofetil and etanercept, are currently being studied, but knowledge of how effective they are and how quickly they work are not yet available.
      
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OBJECTIVE MMF,an inhibitor of inosine monophosphate dehydrogenase,has been found to be effective in the prevention of allograft rejection.This is a prospective study comparing cyclosporine(CyA) Steroid MMF and CyA Steroid Azathioprine (Aza)based immunosupressive regimens in kidney transplant recipients. METHODOLOGY From 9/96 to 7/97,twenty adult recipients of cadaveric renal transplant were entered into the study to receive MMF 2 g/day,1 5 g/day,or ...

OBJECTIVE MMF,an inhibitor of inosine monophosphate dehydrogenase,has been found to be effective in the prevention of allograft rejection.This is a prospective study comparing cyclosporine(CyA) Steroid MMF and CyA Steroid Azathioprine (Aza)based immunosupressive regimens in kidney transplant recipients. METHODOLOGY From 9/96 to 7/97,twenty adult recipients of cadaveric renal transplant were entered into the study to receive MMF 2 g/day,1 5 g/day,or Aa 50 mg/day orally,started pre operatively and continued if allograft demonstrated no post operative acute tubular necrosis.Three groups (MMF 2g/day,n=10;MMF 1 5g/day,n=5;Aza,n=5)received similar dose of CyA and steroid.Patients in each group were equally matched with respect to age ,months on dialysis ,cold ischemia time and lympocytotoxic cross match respectively.The number of infiltrated CD4 + and CD8 + cells and the expression of HLA DR in renal tissue were analyzed by immunohistochemical staining.Patients were followed up for six months. RESULTS Biopsy proven acute rejection occurred in 40%(2/5)Aza and 20%(1/5)MMF 1 5 g/day patients,while there was not episode of acute rejection in MMF 2g/day treated patients(0/10).Increase of interstitial CD4 + and CD8 + cells infiltration and of the expression of HLA DR in renal tubules were found in Aza treated patients.However,there were no differences in serum creatinine levels at 6 months among groups.CMV infection were similar among groups.Adverse events reported with MMF 2 g/day regimen were leukocytopenia and gastrointestinal symptoms.2 patients had to switch to 1 5 g/day after one month treatment. CONCLUSION Compared to Aza,MMF with 2 g/day dosage is more effective in prevention of acute renal allograft rejection.

目的:观察霉酚酸酯(MMF)预防尸体肾移植急性排斥反应的疗效及其副反应。方法:共20例无手术并发症的初次尸肾移植病例,随机分为三组:MMF2g/d组10例,MMF1.5g/d组5例,硫唑嘌呤(AZA)组5例;各组均同时应用环孢霉素(CsA)和强的松(Pred)。定期行相关检查,并常规行移植肾活检。结果:MMF治疗组经活检证实的急性排斥发生率较低,MMF2g组:无(0/10),MMF1.5g组:1例(1/5);AZA组2例(2/5)。移植肾组织化学检查显示,MMF治疗组移植肾组织内CD4+/CD8+浸润细胞数及HLA-DR阳性细胞数低于AZA治疗组。应用MMF治疗者未发现严重毒副反应,而AZA组中有2例发生危及生命的并发症。结论:MMF可有效地减少肾移植急性排斥反应的发生,无严重毒副反应。

AIM: To establish the optimal therapeutic window of cyclosporine A (CsA) for mycophenolate mofetil (MMF) combined with cyclosporine A and prednisone acetate,and analyse clinical effects on patients in renal transplantation. METHODS :One hundred and six-ty-four clinical medical records were summarized with retrospective analysis. RESULTS: The optimal therapeutic window of CsA with MMF was 150-300 ng/ml(less than 1 mo after op-eration), 120-260 ng/ml (1 mo-<3 mo), 110-225 ng/ml (3 mo-<6 mo); The rate of rejection...

AIM: To establish the optimal therapeutic window of cyclosporine A (CsA) for mycophenolate mofetil (MMF) combined with cyclosporine A and prednisone acetate,and analyse clinical effects on patients in renal transplantation. METHODS :One hundred and six-ty-four clinical medical records were summarized with retrospective analysis. RESULTS: The optimal therapeutic window of CsA with MMF was 150-300 ng/ml(less than 1 mo after op-eration), 120-260 ng/ml (1 mo-<3 mo), 110-225 ng/ml (3 mo-<6 mo); The rate of rejection and toxic incidence of MMF group was less than old triple therapy with CsA, aza-thioprine and steroids. CONCLUSION: The MMF combined with cyclosporine and steroids is more effective than control group.

目的:建立霉酚酸酯(MMF)与环孢素A(CsA)及皮质激素(Pred)合用时CsA的治疗窗,分析霉酚酸酯在肾移植术后的临床疗效.方法:对临床164份病例资料进行回顾性分析.结呆:MMF方案CsA的治疗窗为:1mo内为150~300ng/ml,1~3mo 120~260ng/ml,3~6mo 110~225ng/ml;MMF方案中毒反应、排异反应发生均低于经典三联方案(CsA+硫唑嘌呤Aza+Pred).结论:MMF方案优于经典三联方案,可安全、有效地预防肾移植术后急慢性排斥及中毒反应的发生率.

OBJECTIVE To report our experience with mycophenolate mofetil(MMF)treatment in three patients with pauci immune crescentic glomerulonephritis(PCGN). METHODOLOGY Three cases of serum anti neutrophil cytoplasmic antibody negative PCGN were treated with a regime of pulse intravenous methylprednisolon and oral MMF(0 5gram,twice daily).Clinical data as urinary protein excretion,serum creatinine,hematuria were sequentially investigated.Pathology of renal biopsy ...

OBJECTIVE To report our experience with mycophenolate mofetil(MMF)treatment in three patients with pauci immune crescentic glomerulonephritis(PCGN). METHODOLOGY Three cases of serum anti neutrophil cytoplasmic antibody negative PCGN were treated with a regime of pulse intravenous methylprednisolon and oral MMF(0 5gram,twice daily).Clinical data as urinary protein excretion,serum creatinine,hematuria were sequentially investigated.Pathology of renal biopsy was analyzed in all the three cases,including the post treatment rebiopsy data in two of the three cases. RESULTS Clinically,severe azotemia,large amount of proteinuria and hematuria were all presented in the three cases.And pathologically,crescent formation,glomerular capillary necrosis and interstitial arterial vasculitis were found in all the pre treatment biopsy sections.After 8 12 months′MMF treatment,serum creatinine decreased into normal range in 2 of the 3 cases,complete remission of proteinuria was achieved in 2 cases,and hematuria was significantly improved.Analysis of the post treatment rebiopsy data revealed that percentage of crescents formation,degree of active lesions as glomerular capillary necrosis and interstitial arterial vasculitits were remarkably reduced. CONCLUSION Our experience suggests that PCGN as a variant of small size vasculitis with renal involvement is responsive to MMF treatment.

目的:观察霉酚酸酯( M M F) 治疗Ⅲ型新月体肾炎( Ⅲ型 C G N) 的疗效。 方法:3 例血清抗中性粒细胞抗体阴性,肾活检为Ⅲ型 C G N 患者,在甲基强的松龙冲击治疗后应用 M M F(10 g/d) 治疗,观察 M M F 治疗后尿蛋白、血尿和肾功能变化,同时行重复肾活检观察肾组织学改变。 结果:3 例患者治疗后肾脏损伤明显减轻,蛋白尿、血尿均显著减少,随访一年,2 例患者肾功能恢复正常。治疗过程中病情平稳未出现严重副作用。重复肾活检均显示活动性病变显著改善,新月体、节段坏死、肾小球炎细胞浸润、间质血管炎消失或显著减少。一例伴肝硬化和糖尿病者应用 M M F 后也取得显著疗效,肝功能保持良好。 结论: M M F 有望在新月体肾炎的治疗上发挥独特的作用。

 
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