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胰腺癌分级
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  相似匹配句对
     Carcinoma of the Pancreas
     (腺癌)(Ⅰ)
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     Research advancement on the immunotherapy of pancreatic cancer
     腺癌免疫治疗进展
短句来源
     Methods Thirty-six patients with pancreatic cancer were graded according to the vascular involvement with MSTCA by Loyer classification.
     方法36例腺癌患者经MSCTA进行血管侵犯Loyer分级;
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Objective To study the expression of p16 in pancreatic cancer and the relationships among the expression,the clinical patheological characteristics and the prognosis.Methods The expressions of p16 in 40 cases of pancreatic cancer, 12 cases of pancreatic serous adenoma and 16 cases of pancreatitis were detected through the immunohisochemistry S-P method. Results The expressing rate of p16 in the pancreatic cancer was much lower than those in pancreatic serous adenoma and pancreatitis, there was obvious...

Objective To study the expression of p16 in pancreatic cancer and the relationships among the expression,the clinical patheological characteristics and the prognosis.Methods The expressions of p16 in 40 cases of pancreatic cancer, 12 cases of pancreatic serous adenoma and 16 cases of pancreatitis were detected through the immunohisochemistry S-P method. Results The expressing rate of p16 in the pancreatic cancer was much lower than those in pancreatic serous adenoma and pancreatitis, there was obvious differences of expression in the level of pancreatic cancer and ductal adenocarcinoma differentiation of high, medial and low degrees. Conclusion The expression of p16 is closely related to the level and classification of pancreatic cancer, the gene of p16 can be the index of judging the melignant degree of oncocyte and the prognosis.

目的 观察p16蛋白在胰腺癌中的表达 ,探讨其与胰腺癌临床病理学特征及预后的关系。方法 采用免疫组织化学S -P法检测p16蛋白在 4 0例胰腺癌、12例胰腺浆液性腺瘤、16例胰腺炎中的表达情况。结果 p16蛋白在胰腺癌中表达率明显低于胰腺炎及胰腺浆液性腺瘤 ,且p16蛋白在胰腺癌分期及导管腺癌高、中、低分化组间表达有显著差异。结论 p16蛋白的表达与胰腺癌的分级和分期的关系密切 ,p16基因可作为判定瘤细胞恶性程度及预后的客观指标。

Objective To explore the clinical significance of β catenin expression in pancreatic carcinoma.Methods The immunohistochemical staining was performed to detect the expression of β catenin in the specimens of 46 patients with pancreatic carcinoma and the results were statistically analyzed. Results The abnormal expression rate on the membrane was 54.3%, the poorer the differentiation, the higher the abnormal expression rate. The levels of the cases in whom metastasis occurred were much higher than those without...

Objective To explore the clinical significance of β catenin expression in pancreatic carcinoma.Methods The immunohistochemical staining was performed to detect the expression of β catenin in the specimens of 46 patients with pancreatic carcinoma and the results were statistically analyzed. Results The abnormal expression rate on the membrane was 54.3%, the poorer the differentiation, the higher the abnormal expression rate. The levels of the cases in whom metastasis occurred were much higher than those without metastasis. The abnormal cytoplasm expression rate was 21.7%,which had not significant correlation with the clinical indexes, such as staging, tumor size, grading and metastasis. In 23 patients who accepted intervention chemotherapy before operation, the cytoplasm expression rate in those with tumor mass smaller was 0, which was evidently lower than that of those without tumor mass change (33.3%). Moreover, the abnormal membrane and cytoplasm expression rates had remarkable concordance (63.0%).Conclusion The abnormal membrane expression of β catenin may accelerate metastasis, and the abnormal expression of β catenin in cytoplasm may result in cell proliferation.

目的 探讨 β catenin(连环素 )在胰腺癌表达的临床意义。 方法 对手术切除的 4 6例胰腺癌标本进行免疫组化染色 ,检测β catenin在胰腺癌中的表达 ,并分析其和胰腺癌的分级、分期以及有无转移等指标的关系。结果 β catenin在胰腺癌细胞膜的异常表达率为 5 4 .3% ,且分化越差则在细胞膜的异常表达率越高 ,有转移者高于无转移者 ;其在细胞浆的异常表达率为 2 1.7% ,与胰腺癌的分化、分期及有无转移无显著相关性 ,但 2 3例术前介入化疗的患者中 ,肿块缩小者 ( 14例 )在细胞浆的异常表达率为 0 ,显著低于 9例肿块无缩小者的 33.3% ;β catenin在细胞膜和细胞浆异常表达具有一致性 ,为 6 3.0 %。结论 β catenin在细胞膜的异常表达能促进肿瘤转移 ,在细胞浆内的异常表达可能会促进肿瘤细胞的增殖

 
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